Clinical Implications and Hospital Outcome of Immune-Mediated Myositis in Horses

L. Hunyadi, E. A. Sundman, Philip H Kass, D. C. Williams, Monica R Aleman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Immune-mediated myositis (IMM) is a cause of rhabdomyolysis, stiffness, and muscle atrophy predominantly affecting Quarter horses. Limited information is available with regard to outcome, prognostic indicators, and associations with concurrent diseases. Hypothesis/Objectives: To report outcomes and associations between outcome and clinical and laboratory parameters, and presence of concurrent illness. Animals: Sixty-eight horses; 52 Quarter horses and related breeds and 16 other breeds. Methods: Retrospective cohort study (1991–2014). Medical records of horses with histological diagnosis of IMM were reviewed. Data recovery included signalment, laboratory variables, therapy, and outcome. Logistic regression was used to quantify the association between potential prognostic factors and survival to discharge. Results: Quarter horses were younger (mean < 4 years, range 3 months–21 years) than other breeds (mean < 10 years, range 1–23 years). Pathogens causing concurrent or recent infection included S. equi equi, S. equi zooepidemicus, C. pseudotuberculosis, Anaplasma phagocytophilum, herpes virus-1, and influenza. The most common clinical signs consisted of rapidly progressive diffuse symmetrical muscle atrophy (80%), stiff gait (74%), and fever (44%). All horses that received medical therapy immediately upon admission survived to discharge (survival proportion = 87%). Leucocytosis was a common finding (60%). Horses with concurrent fever and other illness had a poor prognosis for hospital discharge. Conclusions and Clinical Importance: Horses with IMM can have a favorable outcome. Horses with concurrent fever and another illness had decreased probability of survival to discharge.

Original languageEnglish (US)
Pages (from-to)170-175
Number of pages6
JournalJournal of Veterinary Internal Medicine
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

myositis
Myositis
Horses
horses
Quarter Horse
Equus
fever
muscular atrophy
breeds
Fever
Muscular Atrophy
rhabdomyolysis
Anaplasma phagocytophilum
therapeutics
gait
cohort studies
influenza
prognosis
Rhabdomyolysis
Leukocytosis

Keywords

  • Equine
  • Inflammation
  • Lymphocytes
  • Myonecrosis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Clinical Implications and Hospital Outcome of Immune-Mediated Myositis in Horses. / Hunyadi, L.; Sundman, E. A.; Kass, Philip H; Williams, D. C.; Aleman, Monica R.

In: Journal of Veterinary Internal Medicine, Vol. 31, No. 1, 01.01.2017, p. 170-175.

Research output: Contribution to journalArticle

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