Clinical illness associated with a commercial tick and flea product in dogs and cats

M. E. Mount, G. Moller, J. Cook, D. M. Holstege, E. R. Richardson, Alex Ardans

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A commercial flea and tick product containing 9.0% fenvalerate for use in dogs and cats was suspected of causing illness. An acute toxicity study was performed in 10 dogs and 10 cats exposed to the product orally (po) and dermally at differing doses. Samples were obtained for DEET and fenvalerate analysis. Oral dosing of dogs and cats produced severe clinical illness at doses as low as 0.66% of a can (7 ounce spray can)/kg body weight. Dermal application of the product resulted in minor clinical abnormalities in dogs. Oral exposure at 0.5% can/kg body weight resulted in severe illness, and dermal application caused severe illness or death in cats at 20% and 40% of a can/kg body weight. The cats receiving 10% of a can/kg body weight dermally became depressed for several hours but recovered uneventfully. Serum DEET concentrations closely paralleled the clinical signs observed in the animals. Serum concentrations of DEET above 20 ppm were considered diagnostic for intoxication. Urine concentrations of DEET above 1 ppm and tissue (liver, bile, and kidney) concentrations of DEET above 10 ppm were supportive of poisoning; values near 100 ppm were diagnostic for fatal poisoning.

Original languageEnglish (US)
Pages (from-to)19-27
Number of pages9
JournalVeterinary and Human Toxicology
Volume33
Issue number1
StatePublished - Mar 4 1991

Fingerprint

DEET
Siphonaptera
Ticks
fenvalerate
ticks
Cats
Dogs
cats
cans
Body Weight
dogs
poisoning
body weight
Poisoning
Skin
acute toxicity
bile
dosage
toxicity testing
Serum

ASJC Scopus subject areas

  • Toxicology
  • veterinary(all)
  • Health, Toxicology and Mutagenesis

Cite this

Mount, M. E., Moller, G., Cook, J., Holstege, D. M., Richardson, E. R., & Ardans, A. (1991). Clinical illness associated with a commercial tick and flea product in dogs and cats. Veterinary and Human Toxicology, 33(1), 19-27.

Clinical illness associated with a commercial tick and flea product in dogs and cats. / Mount, M. E.; Moller, G.; Cook, J.; Holstege, D. M.; Richardson, E. R.; Ardans, Alex.

In: Veterinary and Human Toxicology, Vol. 33, No. 1, 04.03.1991, p. 19-27.

Research output: Contribution to journalArticle

Mount, ME, Moller, G, Cook, J, Holstege, DM, Richardson, ER & Ardans, A 1991, 'Clinical illness associated with a commercial tick and flea product in dogs and cats', Veterinary and Human Toxicology, vol. 33, no. 1, pp. 19-27.
Mount, M. E. ; Moller, G. ; Cook, J. ; Holstege, D. M. ; Richardson, E. R. ; Ardans, Alex. / Clinical illness associated with a commercial tick and flea product in dogs and cats. In: Veterinary and Human Toxicology. 1991 ; Vol. 33, No. 1. pp. 19-27.
@article{f5fdcb28503b4d73932647c31c7062ae,
title = "Clinical illness associated with a commercial tick and flea product in dogs and cats",
abstract = "A commercial flea and tick product containing 9.0{\%} fenvalerate for use in dogs and cats was suspected of causing illness. An acute toxicity study was performed in 10 dogs and 10 cats exposed to the product orally (po) and dermally at differing doses. Samples were obtained for DEET and fenvalerate analysis. Oral dosing of dogs and cats produced severe clinical illness at doses as low as 0.66{\%} of a can (7 ounce spray can)/kg body weight. Dermal application of the product resulted in minor clinical abnormalities in dogs. Oral exposure at 0.5{\%} can/kg body weight resulted in severe illness, and dermal application caused severe illness or death in cats at 20{\%} and 40{\%} of a can/kg body weight. The cats receiving 10{\%} of a can/kg body weight dermally became depressed for several hours but recovered uneventfully. Serum DEET concentrations closely paralleled the clinical signs observed in the animals. Serum concentrations of DEET above 20 ppm were considered diagnostic for intoxication. Urine concentrations of DEET above 1 ppm and tissue (liver, bile, and kidney) concentrations of DEET above 10 ppm were supportive of poisoning; values near 100 ppm were diagnostic for fatal poisoning.",
author = "Mount, {M. E.} and G. Moller and J. Cook and Holstege, {D. M.} and Richardson, {E. R.} and Alex Ardans",
year = "1991",
month = "3",
day = "4",
language = "English (US)",
volume = "33",
pages = "19--27",
journal = "Veterinary and Human Toxicology",
issn = "0145-6296",
publisher = "Comparative Toxicology Laboratories",
number = "1",

}

TY - JOUR

T1 - Clinical illness associated with a commercial tick and flea product in dogs and cats

AU - Mount, M. E.

AU - Moller, G.

AU - Cook, J.

AU - Holstege, D. M.

AU - Richardson, E. R.

AU - Ardans, Alex

PY - 1991/3/4

Y1 - 1991/3/4

N2 - A commercial flea and tick product containing 9.0% fenvalerate for use in dogs and cats was suspected of causing illness. An acute toxicity study was performed in 10 dogs and 10 cats exposed to the product orally (po) and dermally at differing doses. Samples were obtained for DEET and fenvalerate analysis. Oral dosing of dogs and cats produced severe clinical illness at doses as low as 0.66% of a can (7 ounce spray can)/kg body weight. Dermal application of the product resulted in minor clinical abnormalities in dogs. Oral exposure at 0.5% can/kg body weight resulted in severe illness, and dermal application caused severe illness or death in cats at 20% and 40% of a can/kg body weight. The cats receiving 10% of a can/kg body weight dermally became depressed for several hours but recovered uneventfully. Serum DEET concentrations closely paralleled the clinical signs observed in the animals. Serum concentrations of DEET above 20 ppm were considered diagnostic for intoxication. Urine concentrations of DEET above 1 ppm and tissue (liver, bile, and kidney) concentrations of DEET above 10 ppm were supportive of poisoning; values near 100 ppm were diagnostic for fatal poisoning.

AB - A commercial flea and tick product containing 9.0% fenvalerate for use in dogs and cats was suspected of causing illness. An acute toxicity study was performed in 10 dogs and 10 cats exposed to the product orally (po) and dermally at differing doses. Samples were obtained for DEET and fenvalerate analysis. Oral dosing of dogs and cats produced severe clinical illness at doses as low as 0.66% of a can (7 ounce spray can)/kg body weight. Dermal application of the product resulted in minor clinical abnormalities in dogs. Oral exposure at 0.5% can/kg body weight resulted in severe illness, and dermal application caused severe illness or death in cats at 20% and 40% of a can/kg body weight. The cats receiving 10% of a can/kg body weight dermally became depressed for several hours but recovered uneventfully. Serum DEET concentrations closely paralleled the clinical signs observed in the animals. Serum concentrations of DEET above 20 ppm were considered diagnostic for intoxication. Urine concentrations of DEET above 1 ppm and tissue (liver, bile, and kidney) concentrations of DEET above 10 ppm were supportive of poisoning; values near 100 ppm were diagnostic for fatal poisoning.

UR - http://www.scopus.com/inward/record.url?scp=0026035813&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026035813&partnerID=8YFLogxK

M3 - Article

VL - 33

SP - 19

EP - 27

JO - Veterinary and Human Toxicology

JF - Veterinary and Human Toxicology

SN - 0145-6296

IS - 1

ER -