Clinical findings, diagnostic test results, and treatment outcome in cats with spontaneous hyperadrenocorticism: 30 cases

S. Y. Valentin, C. C. Cortright, Richard W Nelson, B. M. Pressler, D. Rosenberg, G. E. Moore, J. C. Scott-Moncrieff

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Spontaneous hyperadrenocorticism (HAC) is rare in cats. Clinical findings, diagnostic test results, and response to various treatment options must be better characterized. Objectives: To report the clinical presentation, clinicopathologic findings, diagnostic imaging results, and response to treatment of cats with HAC. Animals: Cats with spontaneous HAC. Methods: Retrospective descriptive case series. Results: Thirty cats (15 neutered males, 15 spayed females; age, 4.0-17.6 years [median, 13.0 years]) were identified from 10 veterinary referral institutions. The most common reason for referral was unregulated diabetes mellitus; dermatologic abnormalities were the most frequent physical examination finding. Low-dose dexamethasone suppression test results were consistent with HAC in 27 of 28 cats (96%), whereas ACTH stimulation testing was suggestive of HAC in only 9 of 16 cats (56%). Ultrasonographic appearance of the adrenal glands was consistent with the final clinical diagnosis of PDH or ADH in 28 of 30 cats (93%). Of the 17 cats available for follow-up at least 1 month beyond initial diagnosis of HAC, improved quality of life was reported most commonly in cats with PDH treated with trilostane. Conclusions and Clinical Importance: Dermatologic abnormalities or unregulated diabetes mellitus are the most likely reasons for initial referral of cats with HAC. The dexamethasone suppression test is recommended over ACTH stimulation for initial screening of cats with suspected HAC. Diagnostic imaging of the adrenal glands may allow rapid and accurate differentiation of PDH from ADH in cats with confirmed disease, but additional prospective studies are needed.

Original languageEnglish (US)
Pages (from-to)481-487
Number of pages7
JournalJournal of Veterinary Internal Medicine
Volume28
Issue number2
DOIs
StatePublished - Mar 2014

Fingerprint

Adrenocortical Hyperfunction
hyperadrenocorticism
Routine Diagnostic Tests
diagnostic techniques
Cats
cats
Referral and Consultation
adrenal glands
Diagnostic Imaging
dexamethasone
Adrenal Glands
diabetes mellitus
Adrenocorticotropic Hormone
Dexamethasone
Diabetes Mellitus
image analysis
testing
prospective studies
quality of life
clinical examination

Keywords

  • Adrenal gland
  • Diabetes mellitus
  • Pituitary gland
  • Skin fragility

ASJC Scopus subject areas

  • veterinary(all)
  • Medicine(all)

Cite this

Clinical findings, diagnostic test results, and treatment outcome in cats with spontaneous hyperadrenocorticism : 30 cases. / Valentin, S. Y.; Cortright, C. C.; Nelson, Richard W; Pressler, B. M.; Rosenberg, D.; Moore, G. E.; Scott-Moncrieff, J. C.

In: Journal of Veterinary Internal Medicine, Vol. 28, No. 2, 03.2014, p. 481-487.

Research output: Contribution to journalArticle

Valentin, S. Y. ; Cortright, C. C. ; Nelson, Richard W ; Pressler, B. M. ; Rosenberg, D. ; Moore, G. E. ; Scott-Moncrieff, J. C. / Clinical findings, diagnostic test results, and treatment outcome in cats with spontaneous hyperadrenocorticism : 30 cases. In: Journal of Veterinary Internal Medicine. 2014 ; Vol. 28, No. 2. pp. 481-487.
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