Clinical findings and outcomes for dogs with uveodermatologic syndrome

Mitzi K. Zarfoss, Charlotte A. Tusler, Philip H Kass, Keith Montgomery, Christine C. Lim, Freya Mowat, Sara M Thomasy

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE To evaluate signalment, clinical signs, treatment, and factors affecting visual prognosis in dogs with uveodermatologic syndrome (UDS). DESIGN Retrospective case series and nested cohort study. ANIMALS 50 dogs (37 Akitas and 13 non-Akitas) with UDS evaluated at 4 ophthalmology practices. PROCEDURES Data were collected from the medical records regarding signalment, clinical signs, biopsy results, medications, adverse effects, vision and glaucoma status at initial and subsequent examinations, and duration of follow-up. Various factors were examined for associations with development of blindness or glaucoma following initial examination. RESULTS The most common ophthalmic signs included aqueous flare (n = 35 [70%]), iris abnormalities (29 [58%]), retinal detachment (23 [46%]), and choroidal depigmentation or chorioretinal infiltrates (10 [20%]). At initial examination, 36% (18/50) of dogs had glaucoma and 57% (26/46) were blind in both eyes. Twenty-five (50%) dogs had vision at their final visit, representing 78% of the 32 dogs that had vision at initial examination or regained vision during the follow-up period. In dogs that lost vision, median time to permanent blindness in both eyes was 13.5 months (range, 0.4 to 59 months) after initial examination. No significant associations with time to glaucoma or vision loss were identified for signalment variables, specific medications, or duration of clinical signs prior to initial examination. CONCLUSIONS AND CLINICAL RELEVANCE UDS commonly resulted in glaucoma, vision loss, or both in affected dogs. No evaluated factor was associated with visual prognosis; however, a subset of patients maintained vision through to the final recheck examination.

Original languageEnglish (US)
Pages (from-to)1263-1271
Number of pages9
JournalJournal of the American Veterinary Medical Association
Volume252
Issue number10
DOIs
StatePublished - May 15 2018

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glaucoma
Dogs
Glaucoma
dogs
blindness
eyes
Blindness
prognosis
drug therapy
iris (eyes)
ophthalmology
duration
Aqueous Humor
Iris
Retinal Detachment
Ophthalmology
cohort studies
Medical Records
biopsy
Cohort Studies

ASJC Scopus subject areas

  • veterinary(all)

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Clinical findings and outcomes for dogs with uveodermatologic syndrome. / Zarfoss, Mitzi K.; Tusler, Charlotte A.; Kass, Philip H; Montgomery, Keith; Lim, Christine C.; Mowat, Freya; Thomasy, Sara M.

In: Journal of the American Veterinary Medical Association, Vol. 252, No. 10, 15.05.2018, p. 1263-1271.

Research output: Contribution to journalArticle

Zarfoss, Mitzi K. ; Tusler, Charlotte A. ; Kass, Philip H ; Montgomery, Keith ; Lim, Christine C. ; Mowat, Freya ; Thomasy, Sara M. / Clinical findings and outcomes for dogs with uveodermatologic syndrome. In: Journal of the American Veterinary Medical Association. 2018 ; Vol. 252, No. 10. pp. 1263-1271.
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