Clinical features of simian acquired immunodeficiency syndrome (SAIDS) in rhesus monkeys.

R. V. Henrickson, D. H. Maul, N. W. Lerche, K. G. Osborn, Linda J Lowenstine, S. Prahalada, J. L. Sever, D. L. Madden, M. B. Gardner

Research output: Contribution to journalArticle

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Abstract

A syndrome of acquired immunodeficiency has been identified in a group of rhesus monkeys (Macaca mulatta) which died at the California Primate Research Center. Clinical evaluation of these animals revealed that 50% or more had lymphadenopathy, weight loss, and diarrhea. At least 30% had splenomegaly, fever, cutaneous abscesses and/or arthritis/myositis. Two animals had fibrosarcomas. Anemia was seen in 19 animals, lymphopenia in 14, granulocytopenia in four and thrombocytopenia in three. Hepatitis was diagnosed histopathologically in 13. Electrophoresis revealed hypoproteinemia, hypoalbuminemia and hypogammaglobulinemia. Numerous bacterial, protozoal, and viral agents were identified including cytomegalovirus and leukocyte-associated herpesvirus. Pathologic lesions included severe post-reactive depletion of lymphocytes in germinal centers and paracortical regions of lymph nodes. Clinical and pathologic changes indicate an acquired immunodeficiency syndrome which has some similarities to AIDS in humans. This disease in monkeys may provide a model for studying that disease.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalLaboratory Animal Science
Volume34
Issue number2
StatePublished - Apr 1984

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Simian Acquired Immunodeficiency Syndrome
acquired immunodeficiency syndrome
Macaca mulatta
Acquired Immunodeficiency Syndrome
Animals
Monkey Diseases
Lymphocyte Depletion
Hypoproteinemia
myositis
Cytomegalovirus
Agammaglobulinemia
Hypoalbuminemia
splenomegaly
lymphatic diseases
animals
Lymphopenia
Agranulocytosis
fibrosarcoma
Myositis
Germinal Center

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Henrickson, R. V., Maul, D. H., Lerche, N. W., Osborn, K. G., Lowenstine, L. J., Prahalada, S., ... Gardner, M. B. (1984). Clinical features of simian acquired immunodeficiency syndrome (SAIDS) in rhesus monkeys. Laboratory Animal Science, 34(2), 140-145.

Clinical features of simian acquired immunodeficiency syndrome (SAIDS) in rhesus monkeys. / Henrickson, R. V.; Maul, D. H.; Lerche, N. W.; Osborn, K. G.; Lowenstine, Linda J; Prahalada, S.; Sever, J. L.; Madden, D. L.; Gardner, M. B.

In: Laboratory Animal Science, Vol. 34, No. 2, 04.1984, p. 140-145.

Research output: Contribution to journalArticle

Henrickson, RV, Maul, DH, Lerche, NW, Osborn, KG, Lowenstine, LJ, Prahalada, S, Sever, JL, Madden, DL & Gardner, MB 1984, 'Clinical features of simian acquired immunodeficiency syndrome (SAIDS) in rhesus monkeys.', Laboratory Animal Science, vol. 34, no. 2, pp. 140-145.
Henrickson RV, Maul DH, Lerche NW, Osborn KG, Lowenstine LJ, Prahalada S et al. Clinical features of simian acquired immunodeficiency syndrome (SAIDS) in rhesus monkeys. Laboratory Animal Science. 1984 Apr;34(2):140-145.
Henrickson, R. V. ; Maul, D. H. ; Lerche, N. W. ; Osborn, K. G. ; Lowenstine, Linda J ; Prahalada, S. ; Sever, J. L. ; Madden, D. L. ; Gardner, M. B. / Clinical features of simian acquired immunodeficiency syndrome (SAIDS) in rhesus monkeys. In: Laboratory Animal Science. 1984 ; Vol. 34, No. 2. pp. 140-145.
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