Clinical features and epidemiology of cryptococcosis in cats and dogs in california: 93 cases (1988-2010)

Sameer R. Trivedi, Jane E Sykes, Matthew S. Cannon, Erik R Wisner, Wieland Meyer, Beverly Sturges, Peter J Dickinson, Lynelle R Johnson

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35 Citations (Scopus)

Abstract

Objective-To compare clinical features of cryptococcosis among cats and dogs in California, determine whether the distribution of involved tissues differs from distribution reported previously in a study in southeastern Australia, and identify Cryptococcus spp isolated from the study population. Design-Retrospective case series. Animals-62 cats and 31 dogs with cryptococcosis. Procedures-Medical records of cats and dogs with cryptococcosis were reviewed. Information collected included geographic location, species, signalment, and tissues or organs involved. Cryptococcosis was confrmed via serology, cytology, histology, or microbial culture, and molecular typing was performed. Odds ratios and 95% confdence intervals were calculated to determine signifcant associations among variables. Other comparisons were evaluated via χ 2 or unpaired t tests. Results-American Cocker Spaniels were overrepresented, compared with other dog breeds. Serum cryptococcal antigen test results were positive in 51 of 53 cats and 15 of 18 dogs tested. Cryptococcus gattii was more commonly detected in cats (7/9 for which species identifcation was performed), and Cryptococcus neoformans was more commonly detected in dogs (6/8). Six of 7 C gattii isolates from cats were molecular type VGIII. Distribution of involved tissues was different between cats and dogs in California and between populations of the present study and those of the previously reported Australian study. Conclusions and Clinical Relevance-Strains of Cryptococcus spp appeared to have host specifcity in dogs and cats. Differences in lesion distribution between geographic locations may refect strain differences or referral bias. Antigen assays alone may not be suffcient for diagnosis of cryptococcosis in cats and dogs.

Original languageEnglish (US)
Pages (from-to)357-369
Number of pages13
JournalJournal of the American Veterinary Medical Association
Volume239
Issue number3
DOIs
StatePublished - Aug 1 2011

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Cryptococcosis
epidemiology
Epidemiology
Cats
Dogs
cats
dogs
Cryptococcus (Tremellomycetes)
Cryptococcus
Geographic Locations
tissue distribution
Tissue Distribution
Cryptococcus gattii
antigens
Cocker Spaniel
cryptococcosis
Antigens
Molecular Typing
Cryptococcus neoformans
strain differences

ASJC Scopus subject areas

  • veterinary(all)

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Clinical features and epidemiology of cryptococcosis in cats and dogs in california : 93 cases (1988-2010). / Trivedi, Sameer R.; Sykes, Jane E; Cannon, Matthew S.; Wisner, Erik R; Meyer, Wieland; Sturges, Beverly; Dickinson, Peter J; Johnson, Lynelle R.

In: Journal of the American Veterinary Medical Association, Vol. 239, No. 3, 01.08.2011, p. 357-369.

Research output: Contribution to journalArticle

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