Abstract
We identified 46 patients with a history of partial seizures, with and without secondarily generalization, who received levetiracetam (LEV) (Keppra®) monotherapy. Patients began LEV either as first line therapy (n = 11) or were converted to LEV monotherapy (n = 35) after failing prior antiepileptic medications (AEDs). Patients were followed up to 12 months after LEV started. The majority of these patients were able to continue on LEV and a small number of patients discontinued LEV secondary to lack of efficacy. One third of the non-seizure free group at 6 months of follow-up had worse seizure control at 12 months and two thirds had the same or better seizure control. Our 1-year follow-up data of LEV as monotherapy suggests that LEV can be effective and well tolerated in adults with either new or difficult to control epilepsy. A prospective, large, long-term double-blind study is needed to confirm this finding.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 139-142 |
| Number of pages | 4 |
| Journal | Seizure |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2005 |
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Keywords
- Levetiracetam
- Monotherapy
- Partial seizures
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health
- Neurology
- Psychology(all)
Cite this
Clinical experience of levetiracetam monotherapy for adults with epilepsy : 1-year follow-up study. / Alsaadi, Taoufik M.; Shatzel, Alan; Marquez, Anna Vinter; Jorgensen, Julie; Tomaszewski Farias, Sarah E.
In: Seizure, Vol. 14, No. 2, 03.2005, p. 139-142.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical experience of levetiracetam monotherapy for adults with epilepsy
T2 - 1-year follow-up study
AU - Alsaadi, Taoufik M.
AU - Shatzel, Alan
AU - Marquez, Anna Vinter
AU - Jorgensen, Julie
AU - Tomaszewski Farias, Sarah E
PY - 2005/3
Y1 - 2005/3
N2 - We identified 46 patients with a history of partial seizures, with and without secondarily generalization, who received levetiracetam (LEV) (Keppra®) monotherapy. Patients began LEV either as first line therapy (n = 11) or were converted to LEV monotherapy (n = 35) after failing prior antiepileptic medications (AEDs). Patients were followed up to 12 months after LEV started. The majority of these patients were able to continue on LEV and a small number of patients discontinued LEV secondary to lack of efficacy. One third of the non-seizure free group at 6 months of follow-up had worse seizure control at 12 months and two thirds had the same or better seizure control. Our 1-year follow-up data of LEV as monotherapy suggests that LEV can be effective and well tolerated in adults with either new or difficult to control epilepsy. A prospective, large, long-term double-blind study is needed to confirm this finding.
AB - We identified 46 patients with a history of partial seizures, with and without secondarily generalization, who received levetiracetam (LEV) (Keppra®) monotherapy. Patients began LEV either as first line therapy (n = 11) or were converted to LEV monotherapy (n = 35) after failing prior antiepileptic medications (AEDs). Patients were followed up to 12 months after LEV started. The majority of these patients were able to continue on LEV and a small number of patients discontinued LEV secondary to lack of efficacy. One third of the non-seizure free group at 6 months of follow-up had worse seizure control at 12 months and two thirds had the same or better seizure control. Our 1-year follow-up data of LEV as monotherapy suggests that LEV can be effective and well tolerated in adults with either new or difficult to control epilepsy. A prospective, large, long-term double-blind study is needed to confirm this finding.
KW - Levetiracetam
KW - Monotherapy
KW - Partial seizures
UR - http://www.scopus.com/inward/record.url?scp=13444269601&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13444269601&partnerID=8YFLogxK
U2 - 10.1016/j.seizure.2004.12.006
DO - 10.1016/j.seizure.2004.12.006
M3 - Article
C2 - 15694569
AN - SCOPUS:13444269601
VL - 14
SP - 139
EP - 142
JO - Seizure : the journal of the British Epilepsy Association
JF - Seizure : the journal of the British Epilepsy Association
SN - 1059-1311
IS - 2
ER -