TY - JOUR
T1 - Clinical experience of levetiracetam monotherapy for adults with epilepsy
T2 - 1-year follow-up study
AU - Alsaadi, Taoufik M.
AU - Shatzel, Alan
AU - Marquez, Anna Vinter
AU - Jorgensen, Julie
AU - Tomaszewski Farias, Sarah E
PY - 2005/3
Y1 - 2005/3
N2 - We identified 46 patients with a history of partial seizures, with and without secondarily generalization, who received levetiracetam (LEV) (Keppra®) monotherapy. Patients began LEV either as first line therapy (n = 11) or were converted to LEV monotherapy (n = 35) after failing prior antiepileptic medications (AEDs). Patients were followed up to 12 months after LEV started. The majority of these patients were able to continue on LEV and a small number of patients discontinued LEV secondary to lack of efficacy. One third of the non-seizure free group at 6 months of follow-up had worse seizure control at 12 months and two thirds had the same or better seizure control. Our 1-year follow-up data of LEV as monotherapy suggests that LEV can be effective and well tolerated in adults with either new or difficult to control epilepsy. A prospective, large, long-term double-blind study is needed to confirm this finding.
AB - We identified 46 patients with a history of partial seizures, with and without secondarily generalization, who received levetiracetam (LEV) (Keppra®) monotherapy. Patients began LEV either as first line therapy (n = 11) or were converted to LEV monotherapy (n = 35) after failing prior antiepileptic medications (AEDs). Patients were followed up to 12 months after LEV started. The majority of these patients were able to continue on LEV and a small number of patients discontinued LEV secondary to lack of efficacy. One third of the non-seizure free group at 6 months of follow-up had worse seizure control at 12 months and two thirds had the same or better seizure control. Our 1-year follow-up data of LEV as monotherapy suggests that LEV can be effective and well tolerated in adults with either new or difficult to control epilepsy. A prospective, large, long-term double-blind study is needed to confirm this finding.
KW - Levetiracetam
KW - Monotherapy
KW - Partial seizures
UR - http://www.scopus.com/inward/record.url?scp=13444269601&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13444269601&partnerID=8YFLogxK
U2 - 10.1016/j.seizure.2004.12.006
DO - 10.1016/j.seizure.2004.12.006
M3 - Article
C2 - 15694569
AN - SCOPUS:13444269601
VL - 14
SP - 139
EP - 142
JO - Seizure : the journal of the British Epilepsy Association
JF - Seizure : the journal of the British Epilepsy Association
SN - 1059-1311
IS - 2
ER -