Clinical experience of levetiracetam monotherapy for adults with epilepsy: 1-year follow-up study

Taoufik M. Alsaadi; Alan Shatzel; Anna Vinter Marquez; Julie Jorgensen; Sarah E Tomaszewski Farias

doi:10.1016/j.seizure.2004.12.006

Clinical experience of levetiracetam monotherapy for adults with epilepsy: 1-year follow-up study

Taoufik M. Alsaadi, Alan Shatzel, Anna Vinter Marquez, Julie Jorgensen, Sarah E Tomaszewski Farias

Neurology

Research output: Contribution to journal › Article

31 Scopus citations

Abstract

We identified 46 patients with a history of partial seizures, with and without secondarily generalization, who received levetiracetam (LEV) (Keppra®) monotherapy. Patients began LEV either as first line therapy (n = 11) or were converted to LEV monotherapy (n = 35) after failing prior antiepileptic medications (AEDs). Patients were followed up to 12 months after LEV started. The majority of these patients were able to continue on LEV and a small number of patients discontinued LEV secondary to lack of efficacy. One third of the non-seizure free group at 6 months of follow-up had worse seizure control at 12 months and two thirds had the same or better seizure control. Our 1-year follow-up data of LEV as monotherapy suggests that LEV can be effective and well tolerated in adults with either new or difficult to control epilepsy. A prospective, large, long-term double-blind study is needed to confirm this finding.

Original language	English (US)
Pages (from-to)	139-142
Number of pages	4
Journal	Seizure
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/j.seizure.2004.12.006
State	Published - Mar 2005

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Keywords

Levetiracetam
Monotherapy
Partial seizures

ASJC Scopus subject areas

Clinical Neurology
Pediatrics, Perinatology, and Child Health
Neurology
Psychology(all)

Cite this

Alsaadi, T. M., Shatzel, A., Marquez, A. V., Jorgensen, J., & Tomaszewski Farias, S. E. (2005). Clinical experience of levetiracetam monotherapy for adults with epilepsy: 1-year follow-up study. Seizure, 14(2), 139-142. https://doi.org/10.1016/j.seizure.2004.12.006

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abstract = "We identified 46 patients with a history of partial seizures, with and without secondarily generalization, who received levetiracetam (LEV) (Keppra{\textregistered}) monotherapy. Patients began LEV either as first line therapy (n = 11) or were converted to LEV monotherapy (n = 35) after failing prior antiepileptic medications (AEDs). Patients were followed up to 12 months after LEV started. The majority of these patients were able to continue on LEV and a small number of patients discontinued LEV secondary to lack of efficacy. One third of the non-seizure free group at 6 months of follow-up had worse seizure control at 12 months and two thirds had the same or better seizure control. Our 1-year follow-up data of LEV as monotherapy suggests that LEV can be effective and well tolerated in adults with either new or difficult to control epilepsy. A prospective, large, long-term double-blind study is needed to confirm this finding.",

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10.1016/j.seizure.2004.12.006