Abstract
Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine neoplasm of possible viral origin and is known for its aggressive behavior. The incidence of MCC has increased in the last 15 years. Merkel cell carcinoma has the potential to metastasize, but rarely involves the central nervous system. Herein, we report three consecutive surgical cases of MCC presenting at a single institution within 1 year. We used intracavitary BCNU wafers (Gliadel®) in two cases. Pathological features, including CK20 positivity, consistent with MCC, were present in all cases. We found 33 published cases of MCC with CNS involvement. We suggest that the incidence of neurometastatic MCC may be increasing, parallel to the increasing incidence of primary MCC. We propose a role for intracavitary BCNU wafers in the treatment of intra-axial neurometastatic MCC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 147-155 |
| Number of pages | 9 |
| Journal | Journal of Neuro-Oncology |
| Volume | 102 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 2011 |
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Keywords
- BCNU
- Brain
- Gliadel
- Merkel cell carcinoma
- Metastasis
ASJC Scopus subject areas
- Clinical Neurology
- Cancer Research
- Oncology
- Neurology
Cite this
Clinical emergence of neurometastatic merkel cell carcinoma : A surgical case series and literature review. / Bailey, Thomasina L.; Fung, Maxwell A; Gandour-Edwards, Regina F; Ellis, William G.; Schrot, Rudolph J.
In: Journal of Neuro-Oncology, Vol. 102, No. 1, 03.2011, p. 147-155.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical emergence of neurometastatic merkel cell carcinoma
T2 - A surgical case series and literature review
AU - Bailey, Thomasina L.
AU - Fung, Maxwell A
AU - Gandour-Edwards, Regina F
AU - Ellis, William G.
AU - Schrot, Rudolph J.
PY - 2011/3
Y1 - 2011/3
N2 - Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine neoplasm of possible viral origin and is known for its aggressive behavior. The incidence of MCC has increased in the last 15 years. Merkel cell carcinoma has the potential to metastasize, but rarely involves the central nervous system. Herein, we report three consecutive surgical cases of MCC presenting at a single institution within 1 year. We used intracavitary BCNU wafers (Gliadel®) in two cases. Pathological features, including CK20 positivity, consistent with MCC, were present in all cases. We found 33 published cases of MCC with CNS involvement. We suggest that the incidence of neurometastatic MCC may be increasing, parallel to the increasing incidence of primary MCC. We propose a role for intracavitary BCNU wafers in the treatment of intra-axial neurometastatic MCC.
AB - Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine neoplasm of possible viral origin and is known for its aggressive behavior. The incidence of MCC has increased in the last 15 years. Merkel cell carcinoma has the potential to metastasize, but rarely involves the central nervous system. Herein, we report three consecutive surgical cases of MCC presenting at a single institution within 1 year. We used intracavitary BCNU wafers (Gliadel®) in two cases. Pathological features, including CK20 positivity, consistent with MCC, were present in all cases. We found 33 published cases of MCC with CNS involvement. We suggest that the incidence of neurometastatic MCC may be increasing, parallel to the increasing incidence of primary MCC. We propose a role for intracavitary BCNU wafers in the treatment of intra-axial neurometastatic MCC.
KW - BCNU
KW - Brain
KW - Gliadel
KW - Merkel cell carcinoma
KW - Metastasis
UR - http://www.scopus.com/inward/record.url?scp=79952185147&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952185147&partnerID=8YFLogxK
U2 - 10.1007/s11060-010-0304-8
DO - 10.1007/s11060-010-0304-8
M3 - Article
C2 - 20668913
AN - SCOPUS:79952185147
VL - 102
SP - 147
EP - 155
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
SN - 0167-594X
IS - 1
ER -