Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein

Claudia A. Landis, Griffith Harsh, John Lyons, Richard L. Davis, Frank Mc cormick, Henry R. Bourne

Research output: Contribution to journalArticlepeer-review

170 Scopus citations

Abstract

Activating mutations in the gene for the α-chain of G8, the stimulatory regulator of adenylyl cyclase, have been identified in human GH-secreting pituitary tumors. Using the polymerase chain reaction and allele-specific oligonucleotide hybridization, we screened 25 GH-secreting tumors for the presence of the activating mutations. We also reviewed the clinical charts of the patients from whom the tumors were removed. Of 25 tumors, 10 (40%) contained activating mutations. Patients in the mutation-positive group came to surgery with smaller tumors and had lower GH levels. The activating mutations identify a subgroup of GH-secreting pituitary tumors that probably arise from a shared oncogenic mechanism.

Original languageEnglish (US)
Pages (from-to)1416-1420
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume71
Issue number6
DOIs
StatePublished - Dec 1990
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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