Abstract
Multiple sclerosis (MS) is an immune-mediated disorder causing inflammation and de-myelination in the central nervous system. As the onset of multiple sclerosis is at a young age, it is one of the leading neurological causes of disability. Disease activity and disability can be measured by neurological assessments and by magnetic resonance imaging. The development of standardized assessments has been a very important step in clinical research in MS. Clinical research in MS has led to a better understanding of the disease itself and has resulted in exciting new therapies. The protocols provided in this unit are four basic clinical and neuroimaging assessments commonly used as outcome measures in clinical research studies of MS subjects. These step-by-step instructions may be used by researchers and neurologists in clinical practice to obtain objective measures of MS disease progression and response to treatments.
| Original language | English (US) |
|---|---|
| Article number | 10.4 |
| Journal | Current Protocols in Neuroscience |
| Issue number | SUPPL.54 |
| DOIs | |
| State | Published - 2011 |
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Keywords
- Clinical trials
- EDSS
- MRI
- MSFC
- Multiple sclerosis
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Clinical and neuroimaging assessments for research studies (including drug trials) in multiple sclerosis. / Apperson, Michelle L; Agius, Mark A.
In: Current Protocols in Neuroscience, No. SUPPL.54, 10.4, 2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical and neuroimaging assessments for research studies (including drug trials) in multiple sclerosis
AU - Apperson, Michelle L
AU - Agius, Mark A.
PY - 2011
Y1 - 2011
N2 - Multiple sclerosis (MS) is an immune-mediated disorder causing inflammation and de-myelination in the central nervous system. As the onset of multiple sclerosis is at a young age, it is one of the leading neurological causes of disability. Disease activity and disability can be measured by neurological assessments and by magnetic resonance imaging. The development of standardized assessments has been a very important step in clinical research in MS. Clinical research in MS has led to a better understanding of the disease itself and has resulted in exciting new therapies. The protocols provided in this unit are four basic clinical and neuroimaging assessments commonly used as outcome measures in clinical research studies of MS subjects. These step-by-step instructions may be used by researchers and neurologists in clinical practice to obtain objective measures of MS disease progression and response to treatments.
AB - Multiple sclerosis (MS) is an immune-mediated disorder causing inflammation and de-myelination in the central nervous system. As the onset of multiple sclerosis is at a young age, it is one of the leading neurological causes of disability. Disease activity and disability can be measured by neurological assessments and by magnetic resonance imaging. The development of standardized assessments has been a very important step in clinical research in MS. Clinical research in MS has led to a better understanding of the disease itself and has resulted in exciting new therapies. The protocols provided in this unit are four basic clinical and neuroimaging assessments commonly used as outcome measures in clinical research studies of MS subjects. These step-by-step instructions may be used by researchers and neurologists in clinical practice to obtain objective measures of MS disease progression and response to treatments.
KW - Clinical trials
KW - EDSS
KW - MRI
KW - MSFC
KW - Multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=79959544026&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959544026&partnerID=8YFLogxK
U2 - 10.1002/0471142301.ns1004s54
DO - 10.1002/0471142301.ns1004s54
M3 - Article
C2 - 21207365
AN - SCOPUS:79959544026
JO - Current Protocols in Neuroscience
JF - Current Protocols in Neuroscience
SN - 1934-8584
IS - SUPPL.54
M1 - 10.4
ER -