Abstract
Objective - To reexamine (via immunohistochemical techniques) canine tissue samples that had been previously classified as gastrointestinal leiomyosarcomas (GILMSs), identify and differentiate gastrointestinal stromal tumors (GISTs) from GILMSs, and compare the biological behavior and clinical course of GISTs and GILMSs in dogs. Design - Retrospective case series. Animals - 42 dogs. Procedures - Medical records of 42 dogs for which a histologic diagnosis of GILMS was confirmed were reviewed for signalment, clinical signs, physical examination findings, results of initial diagnostic tests, surgical findings, adjunctive treatment, location of the tumor, completeness of resection, and outcome after surgery. Archived tumor tissue specimens from each dog were restained via immunohistochemical techniques to differentiate tumor types. Long-term follow-up information was obtained from the medical record or through telephone interviews with owners and referring veterinarians. Results - On the basis of immunohistochemical findings, 28 of 42 tumors were reclassified as GISTs and 4 were reclassified as undifferentiated sarcomas; 10 tumors were GILMSs. In dogs, GISTs developed more frequently in the cecum and large intestine and GILMSs developed more frequently in the stomach and small intestine. Median survival times for dogs with GISTs and GILMSs were 11.6 and 7.8 months, respectively; if only dogs surviving the perioperative period were considered, median survival times were 37.4 and 7.8 months, respectively. These differences, however, were not significant. Conclusions and Clinical Relevance - In dogs, many previously diagnosed GILMSs should be reclassified as GISTs on the basis of results of immunohistochemical staining. The biological behavior of these tumors appears to be different.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1329-1333 |
| Number of pages | 5 |
| Journal | Journal of the American Veterinary Medical Association |
| Volume | 230 |
| Issue number | 9 |
| DOIs | |
| State | Published - May 1 2007 |
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Clinical and immunohistochemical differentiation of gastrointestinal stromal tumors from leiomyosarcomas in dogs : 42 Cases (1990-2003). / Russell, Kelli N.; Mehler, Stephen J.; Skorupski, Katherine A; Baez, Jennifer L.; Shofer, Frances S.; Goldschmidt, Michael H.
In: Journal of the American Veterinary Medical Association, Vol. 230, No. 9, 01.05.2007, p. 1329-1333.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical and immunohistochemical differentiation of gastrointestinal stromal tumors from leiomyosarcomas in dogs
T2 - 42 Cases (1990-2003)
AU - Russell, Kelli N.
AU - Mehler, Stephen J.
AU - Skorupski, Katherine A
AU - Baez, Jennifer L.
AU - Shofer, Frances S.
AU - Goldschmidt, Michael H.
PY - 2007/5/1
Y1 - 2007/5/1
N2 - Objective - To reexamine (via immunohistochemical techniques) canine tissue samples that had been previously classified as gastrointestinal leiomyosarcomas (GILMSs), identify and differentiate gastrointestinal stromal tumors (GISTs) from GILMSs, and compare the biological behavior and clinical course of GISTs and GILMSs in dogs. Design - Retrospective case series. Animals - 42 dogs. Procedures - Medical records of 42 dogs for which a histologic diagnosis of GILMS was confirmed were reviewed for signalment, clinical signs, physical examination findings, results of initial diagnostic tests, surgical findings, adjunctive treatment, location of the tumor, completeness of resection, and outcome after surgery. Archived tumor tissue specimens from each dog were restained via immunohistochemical techniques to differentiate tumor types. Long-term follow-up information was obtained from the medical record or through telephone interviews with owners and referring veterinarians. Results - On the basis of immunohistochemical findings, 28 of 42 tumors were reclassified as GISTs and 4 were reclassified as undifferentiated sarcomas; 10 tumors were GILMSs. In dogs, GISTs developed more frequently in the cecum and large intestine and GILMSs developed more frequently in the stomach and small intestine. Median survival times for dogs with GISTs and GILMSs were 11.6 and 7.8 months, respectively; if only dogs surviving the perioperative period were considered, median survival times were 37.4 and 7.8 months, respectively. These differences, however, were not significant. Conclusions and Clinical Relevance - In dogs, many previously diagnosed GILMSs should be reclassified as GISTs on the basis of results of immunohistochemical staining. The biological behavior of these tumors appears to be different.
AB - Objective - To reexamine (via immunohistochemical techniques) canine tissue samples that had been previously classified as gastrointestinal leiomyosarcomas (GILMSs), identify and differentiate gastrointestinal stromal tumors (GISTs) from GILMSs, and compare the biological behavior and clinical course of GISTs and GILMSs in dogs. Design - Retrospective case series. Animals - 42 dogs. Procedures - Medical records of 42 dogs for which a histologic diagnosis of GILMS was confirmed were reviewed for signalment, clinical signs, physical examination findings, results of initial diagnostic tests, surgical findings, adjunctive treatment, location of the tumor, completeness of resection, and outcome after surgery. Archived tumor tissue specimens from each dog were restained via immunohistochemical techniques to differentiate tumor types. Long-term follow-up information was obtained from the medical record or through telephone interviews with owners and referring veterinarians. Results - On the basis of immunohistochemical findings, 28 of 42 tumors were reclassified as GISTs and 4 were reclassified as undifferentiated sarcomas; 10 tumors were GILMSs. In dogs, GISTs developed more frequently in the cecum and large intestine and GILMSs developed more frequently in the stomach and small intestine. Median survival times for dogs with GISTs and GILMSs were 11.6 and 7.8 months, respectively; if only dogs surviving the perioperative period were considered, median survival times were 37.4 and 7.8 months, respectively. These differences, however, were not significant. Conclusions and Clinical Relevance - In dogs, many previously diagnosed GILMSs should be reclassified as GISTs on the basis of results of immunohistochemical staining. The biological behavior of these tumors appears to be different.
UR - http://www.scopus.com/inward/record.url?scp=34247857388&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247857388&partnerID=8YFLogxK
U2 - 10.2460/javma.230.9.1329
DO - 10.2460/javma.230.9.1329
M3 - Article
C2 - 17472558
AN - SCOPUS:34247857388
VL - 230
SP - 1329
EP - 1333
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
SN - 0003-1488
IS - 9
ER -