Clinical, anatomic, and immunopathologic characterization of Babesia gibsoni infection in the domestic dog (Canis familiaris)

Edward J. Wozniak, Bradd C. Barr, John W. Thomford, Itsuro Yamane, Sean P. McDonough, Peter F Moore, Diane Naydan, Tom W. Robinson, Patricia A Conrad

Research output: Contribution to journalArticle

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Abstract

The pathology associated with acute, chronic, and recrudescent Babesia gibsoni infections was characterized in a group of 6 naturally or experimentally infected, spleen-intact and splenectomized dogs. All experimentally infected dogs became acutely parasitemic, lethargic, anemic, thrombocytopenic, and hemoglobinuric. Anatomic lesions associated with the disease included diffuse nonsuppurative periportal and centrilobular hepatitis, multifocal necrotizing arteritis, membranoproliferative glomerulonephritis, reactive lymphadenopathy, diffuse erythrophagocytosis, and extramedullary hematopoiesis. The density of CD3+ lymphocytes within the liver sinusoids was markedly increased. Aggregates of large mononuclear cells with immunohistochemical features of activated macrophages were demonstrated in the central veins of the liver. Kupffer cells throughout the hepatic sinusoids appeared hypertrophic and prominent. The density of sinusoidal T lymphocytes, macrophages in central veins, and the degree of Kupffer cell hypertrophy were greatest in the splenectomized dogs. Multifocal deposits of IgM antibody were immunohistochemically demonstrated within the walls of inflamed arteries and renal glomeruli. The results of this study suggest that intense immunostimulation resulting in activation and expansion oft and B lymphocyte populations, macrophage recruitment and activation, vasculitis, glomerulonephritis and anemia contribute to the pathology associated with B. gibsoni infections.

Original languageEnglish (US)
Pages (from-to)692-699
Number of pages8
JournalJournal of Parasitology
Volume83
Issue number4
DOIs
StatePublished - Aug 1997

Fingerprint

Babesia gibsoni
Babesia
Kupffer cells
glomerulonephritis
macrophages
Kupffer Cells
Dogs
pathology
liver
dogs
Veins
Liver
kidney glomerulus
immunostimulation (physiological)
Infection
Macrophages
infection
Extramedullary Hematopoiesis
Pathology
arteritis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Parasitology
  • Microbiology

Cite this

Clinical, anatomic, and immunopathologic characterization of Babesia gibsoni infection in the domestic dog (Canis familiaris). / Wozniak, Edward J.; Barr, Bradd C.; Thomford, John W.; Yamane, Itsuro; McDonough, Sean P.; Moore, Peter F; Naydan, Diane; Robinson, Tom W.; Conrad, Patricia A.

In: Journal of Parasitology, Vol. 83, No. 4, 08.1997, p. 692-699.

Research output: Contribution to journalArticle

Wozniak, Edward J. ; Barr, Bradd C. ; Thomford, John W. ; Yamane, Itsuro ; McDonough, Sean P. ; Moore, Peter F ; Naydan, Diane ; Robinson, Tom W. ; Conrad, Patricia A. / Clinical, anatomic, and immunopathologic characterization of Babesia gibsoni infection in the domestic dog (Canis familiaris). In: Journal of Parasitology. 1997 ; Vol. 83, No. 4. pp. 692-699.
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