Abstract
CuI catalyzed 1,3-dipolar cycloaddition 'click chemistry' was used to prepare 18F-radiolabeled peptides. Three ω-[18F]fluoroalkynes were prepared in yields ranging from 36% to 81%. Conjugation of ω-[18F]fluoroalkynes to various peptides decorated with 3-azidopropionic acid via CuI mediated 1,3-dipolar cycloaddition yielded the desired 18F-labeled products in 10 min with yields of 54-99% and excellent radiochemical purity (81-99%). The total synthesis time was 30 min from the end of bombardment.
Original language | English (US) |
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Pages (from-to) | 6681-6684 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 47 |
Issue number | 37 |
DOIs | |
State | Published - Sep 11 2006 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery