Clear cell renal cell carcinoma: identifying the gain of chromosome 20 on multiphasic MDCT

Jonathan R Young, Jocelyn A. Young, Daniel J.A. Margolis, Steven Sauk, Allan J. Pantuck, James Sayre, Steven S. Raman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: To investigate whether multiphasic multidetector computed tomography (MDCT) enhancement can help identify the gain of chromosome 20 in clear cell renal cell carcinomas (RCCs), a rare prognostically significant cytogenetic abnormality. Methods: With the Institutional Review Board approval, we queried our institution’s pathology database to derive a cohort of 52 cases of clear cell RCC with preoperative four-phase renal mass protocol MDCT and karyotypes of the resected specimens during a 10-year period. Each lesion was evaluated for absolute and relative (compared to contralateral normal renal cortex) attenuations in each phase. Relative attenuation was calculated as [(lesion attenuation − cortex attenuation)/cortex attenuation] × 100. The absolute and relative attenuations were compared using t-tests. Results: Clear cell RCCs with the gain of 20 had significantly less nephrographic and excretory phase enhancement than clear cell RCCs without the gain of 20 (86.4 HU vs. 111.4 HU, p = 0.007; 70.0 HU vs. 89.4 HU, p = 0.003; respectively). Additionally, the relative nephrographic and excretory phase attenuations of clear cell RCCs with the gain of 20 were significantly less than that of clear cell RCCs without the gain of 20 (−52.7 vs. −34.7, p = 0.002; −44.9 vs. −31.1, p = 0.005; respectively). Conclusion: Multiphasic MDCT enhancement may assist in identifying the gain of chromosome 20 in clear cell RCCs, if validated in a large prospective trial.

Original languageEnglish (US)
Pages (from-to)2175-2181
Number of pages7
JournalAbdominal Radiology
Volume41
Issue number11
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 20
Multidetector Computed Tomography
Renal Cell Carcinoma
Kidney
Research Ethics Committees
Karyotype
Chromosome Aberrations
Databases
Pathology

Keywords

  • Clear cell renal cell carcinoma
  • Cytogenetics
  • Multidetector computed tomography
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

Cite this

Young, J. R., Young, J. A., Margolis, D. J. A., Sauk, S., Pantuck, A. J., Sayre, J., & Raman, S. S. (2016). Clear cell renal cell carcinoma: identifying the gain of chromosome 20 on multiphasic MDCT. Abdominal Radiology, 41(11), 2175-2181. https://doi.org/10.1007/s00261-016-0813-9

Clear cell renal cell carcinoma : identifying the gain of chromosome 20 on multiphasic MDCT. / Young, Jonathan R; Young, Jocelyn A.; Margolis, Daniel J.A.; Sauk, Steven; Pantuck, Allan J.; Sayre, James; Raman, Steven S.

In: Abdominal Radiology, Vol. 41, No. 11, 01.11.2016, p. 2175-2181.

Research output: Contribution to journalArticle

Young, JR, Young, JA, Margolis, DJA, Sauk, S, Pantuck, AJ, Sayre, J & Raman, SS 2016, 'Clear cell renal cell carcinoma: identifying the gain of chromosome 20 on multiphasic MDCT', Abdominal Radiology, vol. 41, no. 11, pp. 2175-2181. https://doi.org/10.1007/s00261-016-0813-9
Young, Jonathan R ; Young, Jocelyn A. ; Margolis, Daniel J.A. ; Sauk, Steven ; Pantuck, Allan J. ; Sayre, James ; Raman, Steven S. / Clear cell renal cell carcinoma : identifying the gain of chromosome 20 on multiphasic MDCT. In: Abdominal Radiology. 2016 ; Vol. 41, No. 11. pp. 2175-2181.
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abstract = "Purpose: To investigate whether multiphasic multidetector computed tomography (MDCT) enhancement can help identify the gain of chromosome 20 in clear cell renal cell carcinomas (RCCs), a rare prognostically significant cytogenetic abnormality. Methods: With the Institutional Review Board approval, we queried our institution’s pathology database to derive a cohort of 52 cases of clear cell RCC with preoperative four-phase renal mass protocol MDCT and karyotypes of the resected specimens during a 10-year period. Each lesion was evaluated for absolute and relative (compared to contralateral normal renal cortex) attenuations in each phase. Relative attenuation was calculated as [(lesion attenuation − cortex attenuation)/cortex attenuation] × 100. The absolute and relative attenuations were compared using t-tests. Results: Clear cell RCCs with the gain of 20 had significantly less nephrographic and excretory phase enhancement than clear cell RCCs without the gain of 20 (86.4 HU vs. 111.4 HU, p = 0.007; 70.0 HU vs. 89.4 HU, p = 0.003; respectively). Additionally, the relative nephrographic and excretory phase attenuations of clear cell RCCs with the gain of 20 were significantly less than that of clear cell RCCs without the gain of 20 (−52.7 vs. −34.7, p = 0.002; −44.9 vs. −31.1, p = 0.005; respectively). Conclusion: Multiphasic MDCT enhancement may assist in identifying the gain of chromosome 20 in clear cell RCCs, if validated in a large prospective trial.",
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AU - Sayre, James

AU - Raman, Steven S.

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N2 - Purpose: To investigate whether multiphasic multidetector computed tomography (MDCT) enhancement can help identify the gain of chromosome 20 in clear cell renal cell carcinomas (RCCs), a rare prognostically significant cytogenetic abnormality. Methods: With the Institutional Review Board approval, we queried our institution’s pathology database to derive a cohort of 52 cases of clear cell RCC with preoperative four-phase renal mass protocol MDCT and karyotypes of the resected specimens during a 10-year period. Each lesion was evaluated for absolute and relative (compared to contralateral normal renal cortex) attenuations in each phase. Relative attenuation was calculated as [(lesion attenuation − cortex attenuation)/cortex attenuation] × 100. The absolute and relative attenuations were compared using t-tests. Results: Clear cell RCCs with the gain of 20 had significantly less nephrographic and excretory phase enhancement than clear cell RCCs without the gain of 20 (86.4 HU vs. 111.4 HU, p = 0.007; 70.0 HU vs. 89.4 HU, p = 0.003; respectively). Additionally, the relative nephrographic and excretory phase attenuations of clear cell RCCs with the gain of 20 were significantly less than that of clear cell RCCs without the gain of 20 (−52.7 vs. −34.7, p = 0.002; −44.9 vs. −31.1, p = 0.005; respectively). Conclusion: Multiphasic MDCT enhancement may assist in identifying the gain of chromosome 20 in clear cell RCCs, if validated in a large prospective trial.

AB - Purpose: To investigate whether multiphasic multidetector computed tomography (MDCT) enhancement can help identify the gain of chromosome 20 in clear cell renal cell carcinomas (RCCs), a rare prognostically significant cytogenetic abnormality. Methods: With the Institutional Review Board approval, we queried our institution’s pathology database to derive a cohort of 52 cases of clear cell RCC with preoperative four-phase renal mass protocol MDCT and karyotypes of the resected specimens during a 10-year period. Each lesion was evaluated for absolute and relative (compared to contralateral normal renal cortex) attenuations in each phase. Relative attenuation was calculated as [(lesion attenuation − cortex attenuation)/cortex attenuation] × 100. The absolute and relative attenuations were compared using t-tests. Results: Clear cell RCCs with the gain of 20 had significantly less nephrographic and excretory phase enhancement than clear cell RCCs without the gain of 20 (86.4 HU vs. 111.4 HU, p = 0.007; 70.0 HU vs. 89.4 HU, p = 0.003; respectively). Additionally, the relative nephrographic and excretory phase attenuations of clear cell RCCs with the gain of 20 were significantly less than that of clear cell RCCs without the gain of 20 (−52.7 vs. −34.7, p = 0.002; −44.9 vs. −31.1, p = 0.005; respectively). Conclusion: Multiphasic MDCT enhancement may assist in identifying the gain of chromosome 20 in clear cell RCCs, if validated in a large prospective trial.

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