Abstract
Corticosteroids have recently been shown to reduce expected loss of muscle strength in patients with Duchenne muscular dystrophy and extend the time they can walk. We evaluated 43 boys with the condition to determine whether taking corticosteroids is associated with differences in gait pattern, gross motor skills, energy efficiency, and timed motor performance. We used the gait deviation index to quantify the degree of gait pathology and a single measure of gait quality. There were minimal differences in gait pattern, gross motor skills, energy efficiency, or timed motor performance in boys who took corticosteroids compared with those who did not. Clustering by gait deviation index, however, revealed subtle differences between groups in gait patterns, gross motor skills, and energy efficiency. We conclude that, in boys with Duchenne muscular dystrophy, gait pattern deviations are related to function, which can provide further insight into the understanding of disease progression and treatment options to enhance function and maintain ambulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1103-1109 |
| Number of pages | 7 |
| Journal | Journal of Child Neurology |
| Volume | 25 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2010 |
| Externally published | Yes |
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Keywords
- Duchenne muscular dystrophy
- energy
- function
- gait
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health
Cite this
Classification of the gait patterns of boys with Duchenne muscular dystrophy and their relationship to function. / Sienko Thomas, Susan; Buckon, Cathleen E.; Nicorici, Alina; Bagley, Anita; McDonald, Craig M; Sussman, Michael D.
In: Journal of Child Neurology, Vol. 25, No. 9, 09.2010, p. 1103-1109.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Classification of the gait patterns of boys with Duchenne muscular dystrophy and their relationship to function
AU - Sienko Thomas, Susan
AU - Buckon, Cathleen E.
AU - Nicorici, Alina
AU - Bagley, Anita
AU - McDonald, Craig M
AU - Sussman, Michael D.
PY - 2010/9
Y1 - 2010/9
N2 - Corticosteroids have recently been shown to reduce expected loss of muscle strength in patients with Duchenne muscular dystrophy and extend the time they can walk. We evaluated 43 boys with the condition to determine whether taking corticosteroids is associated with differences in gait pattern, gross motor skills, energy efficiency, and timed motor performance. We used the gait deviation index to quantify the degree of gait pathology and a single measure of gait quality. There were minimal differences in gait pattern, gross motor skills, energy efficiency, or timed motor performance in boys who took corticosteroids compared with those who did not. Clustering by gait deviation index, however, revealed subtle differences between groups in gait patterns, gross motor skills, and energy efficiency. We conclude that, in boys with Duchenne muscular dystrophy, gait pattern deviations are related to function, which can provide further insight into the understanding of disease progression and treatment options to enhance function and maintain ambulation.
AB - Corticosteroids have recently been shown to reduce expected loss of muscle strength in patients with Duchenne muscular dystrophy and extend the time they can walk. We evaluated 43 boys with the condition to determine whether taking corticosteroids is associated with differences in gait pattern, gross motor skills, energy efficiency, and timed motor performance. We used the gait deviation index to quantify the degree of gait pathology and a single measure of gait quality. There were minimal differences in gait pattern, gross motor skills, energy efficiency, or timed motor performance in boys who took corticosteroids compared with those who did not. Clustering by gait deviation index, however, revealed subtle differences between groups in gait patterns, gross motor skills, and energy efficiency. We conclude that, in boys with Duchenne muscular dystrophy, gait pattern deviations are related to function, which can provide further insight into the understanding of disease progression and treatment options to enhance function and maintain ambulation.
KW - Duchenne muscular dystrophy
KW - energy
KW - function
KW - gait
UR - http://www.scopus.com/inward/record.url?scp=77956323075&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956323075&partnerID=8YFLogxK
U2 - 10.1177/0883073810371002
DO - 10.1177/0883073810371002
M3 - Article
C2 - 20587736
AN - SCOPUS:77956323075
VL - 25
SP - 1103
EP - 1109
JO - Journal of Child Neurology
JF - Journal of Child Neurology
SN - 0883-0738
IS - 9
ER -