Classification of the gait patterns of boys with Duchenne muscular dystrophy and their relationship to function

Susan Sienko Thomas, Cathleen E. Buckon, Alina Nicorici, Anita Bagley, Craig M McDonald, Michael D. Sussman

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Corticosteroids have recently been shown to reduce expected loss of muscle strength in patients with Duchenne muscular dystrophy and extend the time they can walk. We evaluated 43 boys with the condition to determine whether taking corticosteroids is associated with differences in gait pattern, gross motor skills, energy efficiency, and timed motor performance. We used the gait deviation index to quantify the degree of gait pathology and a single measure of gait quality. There were minimal differences in gait pattern, gross motor skills, energy efficiency, or timed motor performance in boys who took corticosteroids compared with those who did not. Clustering by gait deviation index, however, revealed subtle differences between groups in gait patterns, gross motor skills, and energy efficiency. We conclude that, in boys with Duchenne muscular dystrophy, gait pattern deviations are related to function, which can provide further insight into the understanding of disease progression and treatment options to enhance function and maintain ambulation.

Original languageEnglish (US)
Pages (from-to)1103-1109
Number of pages7
JournalJournal of Child Neurology
Volume25
Issue number9
DOIs
StatePublished - Sep 2010
Externally publishedYes

Fingerprint

Duchenne Muscular Dystrophy
Gait
Motor Skills
Adrenal Cortex Hormones
Muscle Strength
Walking
Cluster Analysis
Disease Progression
Pathology

Keywords

  • Duchenne muscular dystrophy
  • energy
  • function
  • gait

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Classification of the gait patterns of boys with Duchenne muscular dystrophy and their relationship to function. / Sienko Thomas, Susan; Buckon, Cathleen E.; Nicorici, Alina; Bagley, Anita; McDonald, Craig M; Sussman, Michael D.

In: Journal of Child Neurology, Vol. 25, No. 9, 09.2010, p. 1103-1109.

Research output: Contribution to journalArticle

Sienko Thomas, Susan ; Buckon, Cathleen E. ; Nicorici, Alina ; Bagley, Anita ; McDonald, Craig M ; Sussman, Michael D. / Classification of the gait patterns of boys with Duchenne muscular dystrophy and their relationship to function. In: Journal of Child Neurology. 2010 ; Vol. 25, No. 9. pp. 1103-1109.
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