Classification of Proliferative Pulmonary Lesions of the Mouse: Recommendations of the Mouse Models of Human Cancers Consortium

Alexander Yu Nikitin, Ana Alcaraz, Miriam R. Anver, Roderick T. Bronson, Robert Cardiff, Darlene Dixon, Armando E. Fraire, Edward W. Gabrielson, William T. Gunning, Diana C. Haines, Matthew H. Kaufman, R. Ilona Linnoila, Robert R. Maronpot, Alan S. Rabson, Robert L. Reddick, Sabine Rehm, Nora Rozengurt, Hildegard M. Schuller, Elena N. Shmidt, William D. TravisJerrold M. Ward, Tyler Jacks

Research output: Contribution to journalReview article

252 Citations (Scopus)

Abstract

Rapid advances in generating new mouse genetic models for lung neoplasia provide a continuous challenge for pathologists and investigators. Frequently, phenotypes of new models either have no precedents or are arbitrarily attributed according to incongruent human and mouse classifications. Thus, comparative characterization and validation of novel models can be difficult. To address these issues, a series of discussions was initiated by a panel of human, veterinary, and experimental pathologists during the Mouse Models of Human Cancers Consortium (NIH/National Cancer Institute) workshop on mouse models of lung cancer held in Boston on June 20-22, 2001. The panel performed a comparative evaluation of 78 cases of mouse and human lung proliferative lesions, and recommended development of a new practical classification scheme that would (a) allow easier comparison between human and mouse lung neoplasms, (b) accommodate newly emerging mouse neoplasms, and (c) address the interpretation of benign and preinvasive lesions of the mouse lung. Subsequent discussions with additional experts in pulmonary pathology resulted in the current proposal of a new classification. It is anticipated that this classification, as well as the complementary digital atlas of virtual histological slides, will help investigators and pathologists in their characterization of new mouse models, as well as stimulate further research aimed at a better understanding of proliferative lesions of the lung.

Original languageEnglish (US)
Pages (from-to)2307-2316
Number of pages10
JournalCancer Research
Volume64
Issue number7
DOIs
StatePublished - Apr 1 2004

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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Classification of Proliferative Pulmonary Lesions of the Mouse : Recommendations of the Mouse Models of Human Cancers Consortium. / Nikitin, Alexander Yu; Alcaraz, Ana; Anver, Miriam R.; Bronson, Roderick T.; Cardiff, Robert; Dixon, Darlene; Fraire, Armando E.; Gabrielson, Edward W.; Gunning, William T.; Haines, Diana C.; Kaufman, Matthew H.; Linnoila, R. Ilona; Maronpot, Robert R.; Rabson, Alan S.; Reddick, Robert L.; Rehm, Sabine; Rozengurt, Nora; Schuller, Hildegard M.; Shmidt, Elena N.; Travis, William D.; Ward, Jerrold M.; Jacks, Tyler.

In: Cancer Research, Vol. 64, No. 7, 01.04.2004, p. 2307-2316.

Research output: Contribution to journalReview article

Nikitin, AY, Alcaraz, A, Anver, MR, Bronson, RT, Cardiff, R, Dixon, D, Fraire, AE, Gabrielson, EW, Gunning, WT, Haines, DC, Kaufman, MH, Linnoila, RI, Maronpot, RR, Rabson, AS, Reddick, RL, Rehm, S, Rozengurt, N, Schuller, HM, Shmidt, EN, Travis, WD, Ward, JM & Jacks, T 2004, 'Classification of Proliferative Pulmonary Lesions of the Mouse: Recommendations of the Mouse Models of Human Cancers Consortium', Cancer Research, vol. 64, no. 7, pp. 2307-2316. https://doi.org/10.1158/0008-5472.CAN-03-3376
Nikitin, Alexander Yu ; Alcaraz, Ana ; Anver, Miriam R. ; Bronson, Roderick T. ; Cardiff, Robert ; Dixon, Darlene ; Fraire, Armando E. ; Gabrielson, Edward W. ; Gunning, William T. ; Haines, Diana C. ; Kaufman, Matthew H. ; Linnoila, R. Ilona ; Maronpot, Robert R. ; Rabson, Alan S. ; Reddick, Robert L. ; Rehm, Sabine ; Rozengurt, Nora ; Schuller, Hildegard M. ; Shmidt, Elena N. ; Travis, William D. ; Ward, Jerrold M. ; Jacks, Tyler. / Classification of Proliferative Pulmonary Lesions of the Mouse : Recommendations of the Mouse Models of Human Cancers Consortium. In: Cancer Research. 2004 ; Vol. 64, No. 7. pp. 2307-2316.
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AU - Nikitin, Alexander Yu

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AU - Bronson, Roderick T.

AU - Cardiff, Robert

AU - Dixon, Darlene

AU - Fraire, Armando E.

AU - Gabrielson, Edward W.

AU - Gunning, William T.

AU - Haines, Diana C.

AU - Kaufman, Matthew H.

AU - Linnoila, R. Ilona

AU - Maronpot, Robert R.

AU - Rabson, Alan S.

AU - Reddick, Robert L.

AU - Rehm, Sabine

AU - Rozengurt, Nora

AU - Schuller, Hildegard M.

AU - Shmidt, Elena N.

AU - Travis, William D.

AU - Ward, Jerrold M.

AU - Jacks, Tyler

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N2 - Rapid advances in generating new mouse genetic models for lung neoplasia provide a continuous challenge for pathologists and investigators. Frequently, phenotypes of new models either have no precedents or are arbitrarily attributed according to incongruent human and mouse classifications. Thus, comparative characterization and validation of novel models can be difficult. To address these issues, a series of discussions was initiated by a panel of human, veterinary, and experimental pathologists during the Mouse Models of Human Cancers Consortium (NIH/National Cancer Institute) workshop on mouse models of lung cancer held in Boston on June 20-22, 2001. The panel performed a comparative evaluation of 78 cases of mouse and human lung proliferative lesions, and recommended development of a new practical classification scheme that would (a) allow easier comparison between human and mouse lung neoplasms, (b) accommodate newly emerging mouse neoplasms, and (c) address the interpretation of benign and preinvasive lesions of the mouse lung. Subsequent discussions with additional experts in pulmonary pathology resulted in the current proposal of a new classification. It is anticipated that this classification, as well as the complementary digital atlas of virtual histological slides, will help investigators and pathologists in their characterization of new mouse models, as well as stimulate further research aimed at a better understanding of proliferative lesions of the lung.

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