Classification of osteoarthritis biomarkers: a proposed approach

D. C. Bauer, D. J. Hunter, S. B. Abramson, M. Attur, M. Corr, D. Felson, D. Heinegård, J. M. Jordan, T. B. Kepler, Nancy E Lane, T. Saxne, B. Tyree, V. B. Kraus, (V Kraus, Chair) For the Osteoarthritis Biomarkers Network

Research output: Contribution to journalArticle

242 Citations (Scopus)

Abstract

Objective: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist in disease diagnosis and assessment of disease severity, risk of onset, and progression. As effective agents for OA are developed and tested in clinical studies, biomarkers that reliably mirror or predict the progression or amelioration of OA will also be needed. Methods: The NIH-funded OA Biomarkers Network is a multidisciplinary group interested in the development and validation of OA biomarkers. This review summarizes our efforts to characterize and classify OA biomarkers. Results: We propose the "BIPED" biomarker classification (which stands for Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic), and offer suggestions on optimal study design and analytic methods for use in OA investigations. Conclusion: The BIPED classification provides specific biomarker definitions with the goal of improving our ability to develop and analyze OA biomarkers, and to communicate these advances within a common framework.

Original languageEnglish (US)
Pages (from-to)723-727
Number of pages5
JournalOsteoarthritis and Cartilage
Volume14
Issue number8
DOIs
StatePublished - Aug 2006

Fingerprint

Biomarkers
Osteoarthritis
Mirrors
Research Personnel

Keywords

  • Biomarkers
  • Osteoarthritis
  • Study design

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Bauer, D. C., Hunter, D. J., Abramson, S. B., Attur, M., Corr, M., Felson, D., ... For the Osteoarthritis Biomarkers Network, V. K. C. (2006). Classification of osteoarthritis biomarkers: a proposed approach. Osteoarthritis and Cartilage, 14(8), 723-727. https://doi.org/10.1016/j.joca.2006.04.001

Classification of osteoarthritis biomarkers : a proposed approach. / Bauer, D. C.; Hunter, D. J.; Abramson, S. B.; Attur, M.; Corr, M.; Felson, D.; Heinegård, D.; Jordan, J. M.; Kepler, T. B.; Lane, Nancy E; Saxne, T.; Tyree, B.; Kraus, V. B.; For the Osteoarthritis Biomarkers Network, (V Kraus, Chair).

In: Osteoarthritis and Cartilage, Vol. 14, No. 8, 08.2006, p. 723-727.

Research output: Contribution to journalArticle

Bauer, DC, Hunter, DJ, Abramson, SB, Attur, M, Corr, M, Felson, D, Heinegård, D, Jordan, JM, Kepler, TB, Lane, NE, Saxne, T, Tyree, B, Kraus, VB & For the Osteoarthritis Biomarkers Network, VKC 2006, 'Classification of osteoarthritis biomarkers: a proposed approach', Osteoarthritis and Cartilage, vol. 14, no. 8, pp. 723-727. https://doi.org/10.1016/j.joca.2006.04.001
Bauer DC, Hunter DJ, Abramson SB, Attur M, Corr M, Felson D et al. Classification of osteoarthritis biomarkers: a proposed approach. Osteoarthritis and Cartilage. 2006 Aug;14(8):723-727. https://doi.org/10.1016/j.joca.2006.04.001
Bauer, D. C. ; Hunter, D. J. ; Abramson, S. B. ; Attur, M. ; Corr, M. ; Felson, D. ; Heinegård, D. ; Jordan, J. M. ; Kepler, T. B. ; Lane, Nancy E ; Saxne, T. ; Tyree, B. ; Kraus, V. B. ; For the Osteoarthritis Biomarkers Network, (V Kraus, Chair). / Classification of osteoarthritis biomarkers : a proposed approach. In: Osteoarthritis and Cartilage. 2006 ; Vol. 14, No. 8. pp. 723-727.
@article{ac72b111d09b426fbc41bba08a58f746,
title = "Classification of osteoarthritis biomarkers: a proposed approach",
abstract = "Objective: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist in disease diagnosis and assessment of disease severity, risk of onset, and progression. As effective agents for OA are developed and tested in clinical studies, biomarkers that reliably mirror or predict the progression or amelioration of OA will also be needed. Methods: The NIH-funded OA Biomarkers Network is a multidisciplinary group interested in the development and validation of OA biomarkers. This review summarizes our efforts to characterize and classify OA biomarkers. Results: We propose the {"}BIPED{"} biomarker classification (which stands for Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic), and offer suggestions on optimal study design and analytic methods for use in OA investigations. Conclusion: The BIPED classification provides specific biomarker definitions with the goal of improving our ability to develop and analyze OA biomarkers, and to communicate these advances within a common framework.",
keywords = "Biomarkers, Osteoarthritis, Study design",
author = "Bauer, {D. C.} and Hunter, {D. J.} and Abramson, {S. B.} and M. Attur and M. Corr and D. Felson and D. Heineg{\aa}rd and Jordan, {J. M.} and Kepler, {T. B.} and Lane, {Nancy E} and T. Saxne and B. Tyree and Kraus, {V. B.} and {For the Osteoarthritis Biomarkers Network}, {(V Kraus, Chair)}",
year = "2006",
month = "8",
doi = "10.1016/j.joca.2006.04.001",
language = "English (US)",
volume = "14",
pages = "723--727",
journal = "Osteoarthritis and Cartilage",
issn = "1063-4584",
publisher = "W.B. Saunders Ltd",
number = "8",

}

TY - JOUR

T1 - Classification of osteoarthritis biomarkers

T2 - a proposed approach

AU - Bauer, D. C.

AU - Hunter, D. J.

AU - Abramson, S. B.

AU - Attur, M.

AU - Corr, M.

AU - Felson, D.

AU - Heinegård, D.

AU - Jordan, J. M.

AU - Kepler, T. B.

AU - Lane, Nancy E

AU - Saxne, T.

AU - Tyree, B.

AU - Kraus, V. B.

AU - For the Osteoarthritis Biomarkers Network, (V Kraus, Chair)

PY - 2006/8

Y1 - 2006/8

N2 - Objective: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist in disease diagnosis and assessment of disease severity, risk of onset, and progression. As effective agents for OA are developed and tested in clinical studies, biomarkers that reliably mirror or predict the progression or amelioration of OA will also be needed. Methods: The NIH-funded OA Biomarkers Network is a multidisciplinary group interested in the development and validation of OA biomarkers. This review summarizes our efforts to characterize and classify OA biomarkers. Results: We propose the "BIPED" biomarker classification (which stands for Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic), and offer suggestions on optimal study design and analytic methods for use in OA investigations. Conclusion: The BIPED classification provides specific biomarker definitions with the goal of improving our ability to develop and analyze OA biomarkers, and to communicate these advances within a common framework.

AB - Objective: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist in disease diagnosis and assessment of disease severity, risk of onset, and progression. As effective agents for OA are developed and tested in clinical studies, biomarkers that reliably mirror or predict the progression or amelioration of OA will also be needed. Methods: The NIH-funded OA Biomarkers Network is a multidisciplinary group interested in the development and validation of OA biomarkers. This review summarizes our efforts to characterize and classify OA biomarkers. Results: We propose the "BIPED" biomarker classification (which stands for Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic), and offer suggestions on optimal study design and analytic methods for use in OA investigations. Conclusion: The BIPED classification provides specific biomarker definitions with the goal of improving our ability to develop and analyze OA biomarkers, and to communicate these advances within a common framework.

KW - Biomarkers

KW - Osteoarthritis

KW - Study design

UR - http://www.scopus.com/inward/record.url?scp=33745615815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745615815&partnerID=8YFLogxK

U2 - 10.1016/j.joca.2006.04.001

DO - 10.1016/j.joca.2006.04.001

M3 - Article

C2 - 16733093

AN - SCOPUS:33745615815

VL - 14

SP - 723

EP - 727

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

SN - 1063-4584

IS - 8

ER -