Classification of osteoarthritis biomarkers: a proposed approach

D. C. Bauer, D. J. Hunter, S. B. Abramson, M. Attur, M. Corr, D. Felson, D. Heinegård, J. M. Jordan, T. B. Kepler, Nancy E Lane, T. Saxne, B. Tyree, V. B. Kraus, (V Kraus, Chair) For the Osteoarthritis Biomarkers Network

Research output: Contribution to journalArticlepeer-review

294 Scopus citations


Objective: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist in disease diagnosis and assessment of disease severity, risk of onset, and progression. As effective agents for OA are developed and tested in clinical studies, biomarkers that reliably mirror or predict the progression or amelioration of OA will also be needed. Methods: The NIH-funded OA Biomarkers Network is a multidisciplinary group interested in the development and validation of OA biomarkers. This review summarizes our efforts to characterize and classify OA biomarkers. Results: We propose the "BIPED" biomarker classification (which stands for Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic), and offer suggestions on optimal study design and analytic methods for use in OA investigations. Conclusion: The BIPED classification provides specific biomarker definitions with the goal of improving our ability to develop and analyze OA biomarkers, and to communicate these advances within a common framework.

Original languageEnglish (US)
Pages (from-to)723-727
Number of pages5
JournalOsteoarthritis and Cartilage
Issue number8
StatePublished - Aug 2006


  • Biomarkers
  • Osteoarthritis
  • Study design

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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