Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis

P. Invernizzi, M. Ransom, S. Raychaudhuri, R. Kosoy, A. Lleo, R. Shigeta, A. Franke, F. Bossa, C. I. Amos, P. K. Gregersen, K. A. Siminovitch, D. Cusi, P. I W De Bakker, M. Podda, M. Eric Gershwin, Michael F Seldin

Research output: Contribution to journalArticle

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Abstract

Susceptibility to primary biliary cirrhosis (PBC) is strongly associated with human leukocyte antigen (HLA)-region polymorphisms. To determine if associations can be explained by classical HLA determinants, we studied Italian, 676 cases and 1440 controls, genotyped with dense single-nucleotide polymorphisms (SNPs) for which classical HLA alleles and amino acids were imputed. Although previous genome-wide association studies and our results show stronger SNP associations near DQB1, we demonstrate that the HLA signals can be attributed to classical DRB1 and DPB1 genes. Strong support for the predominant role of DRB1 is provided by our conditional analyses. We also demonstrate an independent association of DPB1. Specific HLA-DRB1 genes (08,11 and14) account for most of the DRB1 association signal. Consistent with previous studies, DRB108 (P=1.59×10-11) was the strongest predisposing allele, whereas DRB111 (P=1.42×10-10) was protective. Additionally, DRB114 and the DPB1 association (DPB103:01; P=9.18×10-7) were predisposing risk alleles. No signal was observed in the HLA class 1 or class 3 regions. These findings better define the association of PBC with HLA and specifically support the role of classical HLA-DRB1 and DPB1 genes and alleles in susceptibility to PBC.

Original languageEnglish (US)
Pages (from-to)461-468
Number of pages8
JournalGenes and Immunity
Volume13
Issue number6
DOIs
StatePublished - Sep 2012

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Biliary Liver Cirrhosis
HLA Antigens
Alleles
Single Nucleotide Polymorphism
Genes
Genome-Wide Association Study
Amino Acids

Keywords

  • antigen-binding pocket
  • autoimmune disease
  • genetic risk
  • imputation
  • risk allele

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

Cite this

Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis. / Invernizzi, P.; Ransom, M.; Raychaudhuri, S.; Kosoy, R.; Lleo, A.; Shigeta, R.; Franke, A.; Bossa, F.; Amos, C. I.; Gregersen, P. K.; Siminovitch, K. A.; Cusi, D.; De Bakker, P. I W; Podda, M.; Gershwin, M. Eric; Seldin, Michael F.

In: Genes and Immunity, Vol. 13, No. 6, 09.2012, p. 461-468.

Research output: Contribution to journalArticle

Invernizzi, P, Ransom, M, Raychaudhuri, S, Kosoy, R, Lleo, A, Shigeta, R, Franke, A, Bossa, F, Amos, CI, Gregersen, PK, Siminovitch, KA, Cusi, D, De Bakker, PIW, Podda, M, Gershwin, ME & Seldin, MF 2012, 'Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis', Genes and Immunity, vol. 13, no. 6, pp. 461-468. https://doi.org/10.1038/gene.2012.17
Invernizzi P, Ransom M, Raychaudhuri S, Kosoy R, Lleo A, Shigeta R et al. Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis. Genes and Immunity. 2012 Sep;13(6):461-468. https://doi.org/10.1038/gene.2012.17
Invernizzi, P. ; Ransom, M. ; Raychaudhuri, S. ; Kosoy, R. ; Lleo, A. ; Shigeta, R. ; Franke, A. ; Bossa, F. ; Amos, C. I. ; Gregersen, P. K. ; Siminovitch, K. A. ; Cusi, D. ; De Bakker, P. I W ; Podda, M. ; Gershwin, M. Eric ; Seldin, Michael F. / Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis. In: Genes and Immunity. 2012 ; Vol. 13, No. 6. pp. 461-468.
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AU - Lleo, A.

AU - Shigeta, R.

AU - Franke, A.

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AU - Siminovitch, K. A.

AU - Cusi, D.

AU - De Bakker, P. I W

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