Classic and contemporary imaging of coccidioidomycosis

John P McGahan, D. S. Graves, P. E S Palmer, R. C. Stadalnik, A. B. Dublin

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Coccidioidomycosis is a systemic infection caused by the soil fungus Coccidiodes immitis and is endemic in northern Mexico and the southwest part of the United States, including Texas, New Mexico, Arizona, and California. Isolated human infections have also been reported from Central and South America. In recent years, because the endemic zone has become a major area of population growth and tourism, this infection may be seen in any part of North America. Travelers or those recently transferred from an endemic area may present a puzzling clinical illness and radiographic picture. An even greater diagnostic challenge is the disseminated infection which can devastate the patient many weeks after the primary exposure, and long after the visit to a significant geographic area. Disseminated coccidioidomycosis will be fatal in the majority of cases unless the etiology is recognized and treated. The classic radiographic manifestations of primary disseminated coccidioidomycosis are well documented, but no report has reviewed the findings in conjunction with helpful modern imaging methods such as computed tomography and radionuclide studies. We have reviewed over 300 published articles on coccidioidomycosis, and to these we have added our own experience with 90 cases of primary coccidioidomycosis and 43 cases of disseminated infection. Discussion of epidemiology, pathology, clinical presentations, and treatment are limited to influences on the radiographic and scintigraphic findings.

Original languageEnglish (US)
Pages (from-to)393-404
Number of pages12
JournalAmerican Journal of Roentgenology
Issue number2
StatePublished - 1981

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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