CK-1, a putative chemokine of rainbow trout (Oncorhynchus mykiss)

Brian Dixon, Benny Shum, Erin J. Adams, Katharine Magor, Ronald Hedrick, David G. Muir, Peter Parham

Research output: Contribution to journalReview article

103 Scopus citations

Abstract

Chemokines are small inducible proteins that direct the migration of leukocytes. While chemokines are well characterised in mammals, they have yet to be idendfied in fish. We have isolated a cDNA clone from rainbow trout (Oncorhynchus mykiss) which encodes a protein (CK-1) having structural features typical of chemokines. Amino-acid residues that define the β-chemokines of mammals are conserved in CK-1, including the paired cysteine motif, CC. Further similarities are shared with the C6 subfamily of β-chemokines. In contrast, the organisation of the CK-1 gene is closer to that of mammalian α-chemokine genes than β-chemokine genes. The CK-1 gene is present in all four salmonid species examined and the nucleotide sequences of the exons are highly conserved. CK-1 has characteristics in common with mammalian α and β-chemokine genes, suggesting that this salmonid chemokine gene preserves traits once present in the ancestral chemokine gene from which modern mammalian chemokine genes evolved.

Original languageEnglish (US)
Pages (from-to)341-348
Number of pages8
JournalImmunological Reviews
Volume166
DOIs
StatePublished - Dec 1 1998

ASJC Scopus subject areas

  • Immunology

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