Twenty-one patients with disseminated malignant melanoma were treated with cis-dichlorodiammineplatinum(II) (cis-DDP): ten with cis-DDP alone at a dose of 20 mg/m 2iv x 4 days every 4 weeks and 11 with cis-DDP at a dose of 15 mg/m 2 iv x 4 days combined with DTIC at a dose of 200 mg/m 2 iv x 5 days every 4 weeks. Two of 21 patients (10%) showed a partial response to therapy. There were no complete responses and no apparent increases in length of survival for responders compared to nonresponders. One drug-related death occurred. Otherwise, drug toxicity was acceptable and appeared to be diminished by iv hydration and prolonged administration. In this study, cis-DDP was not effective for treatment of disseminated malignant melanoma.
|Original language||English (US)|
|Number of pages||3|
|Journal||Cancer Treatment Reports|
|State||Published - 1979|
ASJC Scopus subject areas
- Cancer Research