Abstract
Twenty-one patients with disseminated malignant melanoma were treated with cis-dichlorodiammineplatinum(II) (cis-DDP): ten with cis-DDP alone at a dose of 20 mg/m 2iv x 4 days every 4 weeks and 11 with cis-DDP at a dose of 15 mg/m 2 iv x 4 days combined with DTIC at a dose of 200 mg/m 2 iv x 5 days every 4 weeks. Two of 21 patients (10%) showed a partial response to therapy. There were no complete responses and no apparent increases in length of survival for responders compared to nonresponders. One drug-related death occurred. Otherwise, drug toxicity was acceptable and appeared to be diminished by iv hydration and prolonged administration. In this study, cis-DDP was not effective for treatment of disseminated malignant melanoma.
Original language | English (US) |
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Pages (from-to) | 2005-2007 |
Number of pages | 3 |
Journal | Cancer Treatment Reports |
Volume | 63 |
Issue number | 11-12 |
State | Published - 1979 |
ASJC Scopus subject areas
- Cancer Research
- Oncology