The cardiovascular effects of equipoxent (minimum alveolar concentration) doses of halothane versus halothane plus 25% N 2O (H25N 2O) in spontaneously breathing dogs do not differ except that nitrous oxide increased mean arterial pressure (AP) and decreased arterial oxygen partial pressure (Pao 2). When 75% nitrous oxide was added to halothane anesthesia, AP, mean pulmonary artery pressure, heart rate, cardiac output, stroke volume, total peripheral resistance and left ventricular work increased and Pao 2 and hemoglobin saturation decreased. Arterial oxygen tensions below 80 torr were common at moderate and deep anesthetic levels of halothane plus 75% N 2O (H75N 2O). The specific contribution of N 2O, hypoxemia, hypercapnia, or temporal recovery (or a combination of these) in producing cardiovascular stimulation were not determined.
|Original language||English (US)|
|Number of pages||4|
|Journal||American Journal of Veterinary Research|
|State||Published - Jan 1 1975|
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