Circulatory effects of halothane and halothane nitrous oxide anesthesia in the dog: spontaneous ventilation

Eugene Steffey, J. R. Gillespie, J. D. Berry, E. I. Eger, E. A. Rhode

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The cardiovascular effects of equipoxent (minimum alveolar concentration) doses of halothane versus halothane plus 25% N 2O (H25N 2O) in spontaneously breathing dogs do not differ except that nitrous oxide increased mean arterial pressure (AP) and decreased arterial oxygen partial pressure (Pao 2). When 75% nitrous oxide was added to halothane anesthesia, AP, mean pulmonary artery pressure, heart rate, cardiac output, stroke volume, total peripheral resistance and left ventricular work increased and Pao 2 and hemoglobin saturation decreased. Arterial oxygen tensions below 80 torr were common at moderate and deep anesthetic levels of halothane plus 75% N 2O (H75N 2O). The specific contribution of N 2O, hypoxemia, hypercapnia, or temporal recovery (or a combination of these) in producing cardiovascular stimulation were not determined.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalAmerican Journal of Veterinary Research
Volume36
Issue number2
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • veterinary(all)

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