Circulating oxidised low-density lipoprotein and intercellular adhesion molecule-1 and risk of type 2 diabetes mellitus: The Atherosclerosis Risk in Communities Study

R. C. Hoogeveen, C. M. Ballantyne, Heejung Bang, G. Heiss, B. B. Duncan, A. R. Folsom, J. S. Pankow

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Aims/hypothesis: To evaluate the role of oxidative stress and inflammation in the aetiology of type 2 diabetes, we examined the association of oxidised LDL (ox-LDL) and soluble intercellular adhesion molecule-1 (sICAM-1) levels with type 2 diabetes incidence over 9 years in the Atherosclerosis Risk in Communities Study. Materials and methods: In a large, prospective, case-cohort design, ox-LDL and sICAM-1 were measured in stored plasma samples collected at baseline in stratified samples of 581 diabetes cases and 572 non-cases selected from 10,275 middle-aged men and women without prevalent diabetes at baseline. Results: Compared with non-cases, diabetes cases had significantly higher mean baseline levels of ox-LDL and sICAM-1. Elevated ox-LDL and sICAM-1 were both associated with increased risk of incident diabetes after adjustment for age, sex, race and centre, with hazard ratios for the highest vs lowest tertiles of 1.68 (95% CI 1.25-2.24) and 1.91 (95% CI 1.45-2.50), respectively. After additional adjustment for fasting glucose, waist circumference, HDL-cholesterol, triacylglycerol, hypertension and C-reactive protein, only sICAM-1 remained an independent predictor of incident diabetes (hazard ratio 1.50; 95% CI 1.02-2.23). Conclusions/interpretation: In this community-based cohort of middle-aged US adults, elevated plasma ox-LDL and sICAM-1 levels were associated with increased risk of type 2 diabetes. Measurement of ICAM-1 or ox-LDL, or other measures related to inflammation or oxidative stress, may be helpful in identifying those patient populations in which to test whether novel therapies that inhibit specific pathways related to inflammation or oxidative stress are beneficial in the prevention of diabetes in humans.

Original languageEnglish (US)
Pages (from-to)36-42
Number of pages7
JournalDiabetologia
Volume50
Issue number1
DOIs
StatePublished - Jan 2007
Externally publishedYes

Fingerprint

Intercellular Adhesion Molecule-1
Type 2 Diabetes Mellitus
Atherosclerosis
Oxidative Stress
Inflammation
Waist Circumference
oxidized low density lipoprotein
C-Reactive Protein
HDL Cholesterol
Fasting
Triglycerides
Hypertension
Glucose
Incidence
Population

Keywords

  • Diabetes
  • ICAM-1
  • Inflammation
  • Oxidised LDL

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Circulating oxidised low-density lipoprotein and intercellular adhesion molecule-1 and risk of type 2 diabetes mellitus : The Atherosclerosis Risk in Communities Study. / Hoogeveen, R. C.; Ballantyne, C. M.; Bang, Heejung; Heiss, G.; Duncan, B. B.; Folsom, A. R.; Pankow, J. S.

In: Diabetologia, Vol. 50, No. 1, 01.2007, p. 36-42.

Research output: Contribution to journalArticle

Hoogeveen, R. C. ; Ballantyne, C. M. ; Bang, Heejung ; Heiss, G. ; Duncan, B. B. ; Folsom, A. R. ; Pankow, J. S. / Circulating oxidised low-density lipoprotein and intercellular adhesion molecule-1 and risk of type 2 diabetes mellitus : The Atherosclerosis Risk in Communities Study. In: Diabetologia. 2007 ; Vol. 50, No. 1. pp. 36-42.
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