Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters

C. S. Kim, H. S. Park, T. Kawada, J. H. Kim, D. Lim, Neil Hubbard, B. S. Kwon, Kent L Erickson, R. Yu

Research output: Contribution to journalArticle

266 Citations (Scopus)

Abstract

Background:Chemotactic cytokines, referred to as chemokines, play an important role in leukocyte trafficking. The circulating levels of chemokines have been shown to increase in inflammatory processes including obesity-related pathologies (e.g. atherosclerosis and diabetes). However, little is currently known about the relationship between chemokines and human obesity. In the present study, we investigated the circulating levels of selected chemokines (monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), leukotactin-1, interleukin-8 (IL-8)) and the association between the chemokine levels and obesity-related parameters: body mass index (BMI), waist circumference, fasting glucose and insulin levels, lipids profile, and the level of C-reactive protein (CRP).Methods:A total of 100 subjects, 50 obese (BMI≥25 kg/m2) and 50 who were not obese (BMI<25 kg/m2) participated in the present study. The levels of chemokines and CRP were measured in a fasting state serum by sandwich enzyme-linked immunosorbent assay. Total cholesterol, high-density lipoprotein (HDL)-cholesterol, triglyceride, glucose, and insulin levels were measured by enzymatic analysis and immunoassay.Results:The circulating levels of MCP-1 and IL-8 in the serum were significantly (P<0.05) higher in obese subjects (BMI>30 kg/m2) compared with those of nonobese controls (BMI<25 kg/m2). The levels of CRP were positively correlated with BMI (P<0.001) or waist circumference (P<0.0001). The levels of MCP-1 and IL-8 were positively related to BMI (MCP-1, P<0.02; IL-8, P<0.01) and/or waist circumference (MCP-1, P<0.009; IL-8, P<0.03). The levels of MCP-1 were positively related to the levels of CRP (P<0.007) or interleukin-6 (IL-6) (P<0.0001), and negatively related to the levels of HDL-cholesterol (P<0.01). Homeostasis model assessment (HOMA) score was positively related to the levels of MCP-1 (P<0.02) or IL-8 (P<0.03) in obese subject.Discussion:Our data demonstrated that the circulating levels of MCP-1 and IL-8 are related to obesity-related parameters such as BMI, waist circumference, CRP, IL-6, HOMA and HDL-cholesterol. These findings suggest that the circulating MCP-1 and/or IL-8 may be a potential candidate linking obesity with obesity-related metabolic complications such as atherosclerosis and diabetes.

Original languageEnglish (US)
Pages (from-to)1347-1355
Number of pages9
JournalInternational Journal of Obesity
Volume30
Issue number9
DOIs
StatePublished - Sep 21 2006

Fingerprint

Chemokine CCL2
interleukin-8
Interleukin-8
obesity
chemokines
Obesity
Chemokines
waist circumference
C-reactive protein
body mass index
Waist Circumference
Body Mass Index
C-Reactive Protein
atherosclerosis
high density lipoprotein cholesterol
interleukin-6
HDL Cholesterol
diabetes
Interleukin-6
homeostasis

Keywords

  • BMI
  • IL-8
  • Inflammation
  • MCP-1
  • Metabolic complications
  • Obesity-related pathologies

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters. / Kim, C. S.; Park, H. S.; Kawada, T.; Kim, J. H.; Lim, D.; Hubbard, Neil; Kwon, B. S.; Erickson, Kent L; Yu, R.

In: International Journal of Obesity, Vol. 30, No. 9, 21.09.2006, p. 1347-1355.

Research output: Contribution to journalArticle

Kim, C. S. ; Park, H. S. ; Kawada, T. ; Kim, J. H. ; Lim, D. ; Hubbard, Neil ; Kwon, B. S. ; Erickson, Kent L ; Yu, R. / Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters. In: International Journal of Obesity. 2006 ; Vol. 30, No. 9. pp. 1347-1355.
@article{ec7e27ac753b48c78638bdc70b1417fc,
title = "Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters",
abstract = "Background:Chemotactic cytokines, referred to as chemokines, play an important role in leukocyte trafficking. The circulating levels of chemokines have been shown to increase in inflammatory processes including obesity-related pathologies (e.g. atherosclerosis and diabetes). However, little is currently known about the relationship between chemokines and human obesity. In the present study, we investigated the circulating levels of selected chemokines (monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), leukotactin-1, interleukin-8 (IL-8)) and the association between the chemokine levels and obesity-related parameters: body mass index (BMI), waist circumference, fasting glucose and insulin levels, lipids profile, and the level of C-reactive protein (CRP).Methods:A total of 100 subjects, 50 obese (BMI≥25 kg/m2) and 50 who were not obese (BMI<25 kg/m2) participated in the present study. The levels of chemokines and CRP were measured in a fasting state serum by sandwich enzyme-linked immunosorbent assay. Total cholesterol, high-density lipoprotein (HDL)-cholesterol, triglyceride, glucose, and insulin levels were measured by enzymatic analysis and immunoassay.Results:The circulating levels of MCP-1 and IL-8 in the serum were significantly (P<0.05) higher in obese subjects (BMI>30 kg/m2) compared with those of nonobese controls (BMI<25 kg/m2). The levels of CRP were positively correlated with BMI (P<0.001) or waist circumference (P<0.0001). The levels of MCP-1 and IL-8 were positively related to BMI (MCP-1, P<0.02; IL-8, P<0.01) and/or waist circumference (MCP-1, P<0.009; IL-8, P<0.03). The levels of MCP-1 were positively related to the levels of CRP (P<0.007) or interleukin-6 (IL-6) (P<0.0001), and negatively related to the levels of HDL-cholesterol (P<0.01). Homeostasis model assessment (HOMA) score was positively related to the levels of MCP-1 (P<0.02) or IL-8 (P<0.03) in obese subject.Discussion:Our data demonstrated that the circulating levels of MCP-1 and IL-8 are related to obesity-related parameters such as BMI, waist circumference, CRP, IL-6, HOMA and HDL-cholesterol. These findings suggest that the circulating MCP-1 and/or IL-8 may be a potential candidate linking obesity with obesity-related metabolic complications such as atherosclerosis and diabetes.",
keywords = "BMI, IL-8, Inflammation, MCP-1, Metabolic complications, Obesity-related pathologies",
author = "Kim, {C. S.} and Park, {H. S.} and T. Kawada and Kim, {J. H.} and D. Lim and Neil Hubbard and Kwon, {B. S.} and Erickson, {Kent L} and R. Yu",
year = "2006",
month = "9",
day = "21",
doi = "10.1038/sj.ijo.0803259",
language = "English (US)",
volume = "30",
pages = "1347--1355",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",
number = "9",

}

TY - JOUR

T1 - Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters

AU - Kim, C. S.

AU - Park, H. S.

AU - Kawada, T.

AU - Kim, J. H.

AU - Lim, D.

AU - Hubbard, Neil

AU - Kwon, B. S.

AU - Erickson, Kent L

AU - Yu, R.

PY - 2006/9/21

Y1 - 2006/9/21

N2 - Background:Chemotactic cytokines, referred to as chemokines, play an important role in leukocyte trafficking. The circulating levels of chemokines have been shown to increase in inflammatory processes including obesity-related pathologies (e.g. atherosclerosis and diabetes). However, little is currently known about the relationship between chemokines and human obesity. In the present study, we investigated the circulating levels of selected chemokines (monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), leukotactin-1, interleukin-8 (IL-8)) and the association between the chemokine levels and obesity-related parameters: body mass index (BMI), waist circumference, fasting glucose and insulin levels, lipids profile, and the level of C-reactive protein (CRP).Methods:A total of 100 subjects, 50 obese (BMI≥25 kg/m2) and 50 who were not obese (BMI<25 kg/m2) participated in the present study. The levels of chemokines and CRP were measured in a fasting state serum by sandwich enzyme-linked immunosorbent assay. Total cholesterol, high-density lipoprotein (HDL)-cholesterol, triglyceride, glucose, and insulin levels were measured by enzymatic analysis and immunoassay.Results:The circulating levels of MCP-1 and IL-8 in the serum were significantly (P<0.05) higher in obese subjects (BMI>30 kg/m2) compared with those of nonobese controls (BMI<25 kg/m2). The levels of CRP were positively correlated with BMI (P<0.001) or waist circumference (P<0.0001). The levels of MCP-1 and IL-8 were positively related to BMI (MCP-1, P<0.02; IL-8, P<0.01) and/or waist circumference (MCP-1, P<0.009; IL-8, P<0.03). The levels of MCP-1 were positively related to the levels of CRP (P<0.007) or interleukin-6 (IL-6) (P<0.0001), and negatively related to the levels of HDL-cholesterol (P<0.01). Homeostasis model assessment (HOMA) score was positively related to the levels of MCP-1 (P<0.02) or IL-8 (P<0.03) in obese subject.Discussion:Our data demonstrated that the circulating levels of MCP-1 and IL-8 are related to obesity-related parameters such as BMI, waist circumference, CRP, IL-6, HOMA and HDL-cholesterol. These findings suggest that the circulating MCP-1 and/or IL-8 may be a potential candidate linking obesity with obesity-related metabolic complications such as atherosclerosis and diabetes.

AB - Background:Chemotactic cytokines, referred to as chemokines, play an important role in leukocyte trafficking. The circulating levels of chemokines have been shown to increase in inflammatory processes including obesity-related pathologies (e.g. atherosclerosis and diabetes). However, little is currently known about the relationship between chemokines and human obesity. In the present study, we investigated the circulating levels of selected chemokines (monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), leukotactin-1, interleukin-8 (IL-8)) and the association between the chemokine levels and obesity-related parameters: body mass index (BMI), waist circumference, fasting glucose and insulin levels, lipids profile, and the level of C-reactive protein (CRP).Methods:A total of 100 subjects, 50 obese (BMI≥25 kg/m2) and 50 who were not obese (BMI<25 kg/m2) participated in the present study. The levels of chemokines and CRP were measured in a fasting state serum by sandwich enzyme-linked immunosorbent assay. Total cholesterol, high-density lipoprotein (HDL)-cholesterol, triglyceride, glucose, and insulin levels were measured by enzymatic analysis and immunoassay.Results:The circulating levels of MCP-1 and IL-8 in the serum were significantly (P<0.05) higher in obese subjects (BMI>30 kg/m2) compared with those of nonobese controls (BMI<25 kg/m2). The levels of CRP were positively correlated with BMI (P<0.001) or waist circumference (P<0.0001). The levels of MCP-1 and IL-8 were positively related to BMI (MCP-1, P<0.02; IL-8, P<0.01) and/or waist circumference (MCP-1, P<0.009; IL-8, P<0.03). The levels of MCP-1 were positively related to the levels of CRP (P<0.007) or interleukin-6 (IL-6) (P<0.0001), and negatively related to the levels of HDL-cholesterol (P<0.01). Homeostasis model assessment (HOMA) score was positively related to the levels of MCP-1 (P<0.02) or IL-8 (P<0.03) in obese subject.Discussion:Our data demonstrated that the circulating levels of MCP-1 and IL-8 are related to obesity-related parameters such as BMI, waist circumference, CRP, IL-6, HOMA and HDL-cholesterol. These findings suggest that the circulating MCP-1 and/or IL-8 may be a potential candidate linking obesity with obesity-related metabolic complications such as atherosclerosis and diabetes.

KW - BMI

KW - IL-8

KW - Inflammation

KW - MCP-1

KW - Metabolic complications

KW - Obesity-related pathologies

UR - http://www.scopus.com/inward/record.url?scp=33748099699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748099699&partnerID=8YFLogxK

U2 - 10.1038/sj.ijo.0803259

DO - 10.1038/sj.ijo.0803259

M3 - Article

C2 - 16534530

AN - SCOPUS:33748099699

VL - 30

SP - 1347

EP - 1355

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 9

ER -