@article{b29ceb6f8b8d438784b5e5512cc56acf,
title = "Circulating integrin α4β7+ CD4 T cells are enriched for proliferative transcriptional programs in HIV infection",
abstract = "HIV preferentially infects α4β7+ CD4 T cells, forming latent reservoirs that contribute to HIV persistence during antiretroviral therapy. However, the properties of α4β7+ CD4 T cells in blood and mucosal compartments remain understudied. Employing two distinct models of HIV infection, HIV-infected humans and simian–human immunodeficiency virus (SHIV)-infected rhesus macaques, we show that α4β7+ CD4 T cells in blood are enriched for genes regulating cell cycle progression and cellular metabolism. Unlike their circulating counterparts, rectal α4β7+ CD4 T cells exhibited a core tissue-residency gene expression program. These features were conserved across primate species, indicating that the environment influences memory T-cell transcriptional networks. Our findings provide an important molecular foundation for understanding the role of α4β7 in HIV infection.",
keywords = "HIV, integrin α4, rectal mucosa, susceptibility, tissue resident memory T cells, β7 CD4 T cells",
author = "Lakshmanappa, {Yashavanth S.} and Roh, {Jamin W.} and Rane, {Niharika N.} and Dinasarapu, {Ashok R.} and Tran, {Daphne D.} and Vijayakumar Velu and Sheth, {Anandi N.} and Igho Ofotokun and Amara, {Rama R.} and Kelley, {Colleen F.} and Elaine Waetjen and Iyer, {Smita S.}",
note = "Funding Information: We thank the study volunteers for their participation in this research. We thank the Yerkes Genomics Core for processing sorted human and rhesus T‐cell subsets. The authors are grateful to Brian Schmidt for depositing files on GEO. We thank George Shaw and Nancy Miller for the SHIV.C.CH505 virus. The authors are grateful to Rachel Rutishauser for scientific discussions. The αβ reagent used in these studies was provided by the NIH Nonhuman Primate Reagent Resource (R24 OD010976 and NIAID contract HHSN 272201300031C). This work was supported by the Center for AIDS Research at Emory University (P30AI050409). RNA sequencing analysis was supported by a supplement to SSI by the Women{\textquoteright}s Interagency HIV Study (WIHS; U01‐AI‐103408). This work was supported by the NIAID grants K01 OD023034, R03 AI138792, 1R21AI143454 (SSI). 4 7 Funding Information: We thank the study volunteers for their participation in this research. We thank the Yerkes Genomics Core for processing sorted human and rhesus T-cell subsets. The authors are grateful to Brian Schmidt for depositing files on GEO. We thank George Shaw and Nancy Miller for the SHIV.C.CH505 virus. The authors are grateful to Rachel Rutishauser for scientific discussions. The ?4?7 reagent used in these studies was provided by the NIH Nonhuman Primate Reagent Resource (R24 OD010976 and NIAID contract HHSN 272201300031C). This work was supported by the Center for AIDS Research at Emory University (P30AI050409). RNA sequencing analysis was supported by a supplement to SSI by the Women?s Interagency HIV Study (WIHS; U01-AI-103408). This work was supported by the NIAID grants K01 OD023034, R03 AI138792, 1R21AI143454 (SSI). Publisher Copyright: {\textcopyright} 2021 Federation of European Biochemical Societies",
year = "2021",
month = sep,
doi = "10.1002/1873-3468.14163",
language = "English (US)",
volume = "595",
pages = "2257--2270",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "17",
}