Circulating concentrations of high-molecular-weight adiponectin are increased following Roux-en-Y gastric bypass surgery

M. M. Swarbrick, I. T. Austrheim-Smith, Kimber Stanhope, M. D. Van Loan, Mohamed R Ali, B. M. Wolfe, Peter J Havel

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Aims/hypothesis: In addition to weight loss, bariatric surgery for severe obesity dramatically alleviates insulin resistance. In this study, we investigated whether circulating concentrations of the high-molecular-weight (HMW) form of adiponectin are increased following gastric bypass surgery. The HMW form is implicated as the multimer responsible for adiponectin's hepatic insulin-sensitising actions. Subjects and methods: We studied 19 women who were undergoing Roux-en-Y gastric bypass surgery. Studies were conducted prior to, and 1 and 12 months after surgery. Results: One month after surgery, total plasma adiponectin concentrations were unchanged. Nevertheless, increases in both HMW (by 40±15%, p=0.006) and the proportion of adiponectin in the HMW form (from 40±2 to 50±2%, p<0.0001) were observed. At 12 months, total and HMW adiponectin concentrations were increased by 58±8% and 118±21%, respectively (both p<0.001). The majority (80%) of the increase of total adiponectin was due to an increase of the HMW form. After adjustment for covariates, increases of HMW and total adiponectin at 12 months were correlated with the decrease of fat mass (HMW, p=0.0076; total, p=0.0302). In subjects with improved insulin sensitivity at 12 months after surgery (n=18), the increase of HMW, but not that of total adiponectin, predicted the relative decrease of insulin resistance (HMW: p=0.0044; total: p=0.0775, after adjustment for covariates). Conclusions/interpretation: These data suggest that the reduction of fat mass following gastric bypass surgery is an important determinant of the increase of HMW adiponectin concentrations, which in turn is associated with and may contribute to the resulting improvement of insulin sensitivity.

Original languageEnglish (US)
Pages (from-to)2552-2558
Number of pages7
JournalDiabetologia
Volume49
Issue number11
DOIs
StatePublished - Nov 2006

Fingerprint

Gastric Bypass
Adiponectin
Molecular Weight
Insulin Resistance
Fats
Bariatric Surgery
Morbid Obesity
Weight Loss
Insulin

Keywords

  • Adiponectin
  • Clinical science
  • Gastric bypass
  • Human
  • Insulin sensitivity
  • Weight regulation

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Circulating concentrations of high-molecular-weight adiponectin are increased following Roux-en-Y gastric bypass surgery. / Swarbrick, M. M.; Austrheim-Smith, I. T.; Stanhope, Kimber; Van Loan, M. D.; Ali, Mohamed R; Wolfe, B. M.; Havel, Peter J.

In: Diabetologia, Vol. 49, No. 11, 11.2006, p. 2552-2558.

Research output: Contribution to journalArticle

Swarbrick, M. M. ; Austrheim-Smith, I. T. ; Stanhope, Kimber ; Van Loan, M. D. ; Ali, Mohamed R ; Wolfe, B. M. ; Havel, Peter J. / Circulating concentrations of high-molecular-weight adiponectin are increased following Roux-en-Y gastric bypass surgery. In: Diabetologia. 2006 ; Vol. 49, No. 11. pp. 2552-2558.
@article{12743c38f52146a1bfd6e357f3bfe34d,
title = "Circulating concentrations of high-molecular-weight adiponectin are increased following Roux-en-Y gastric bypass surgery",
abstract = "Aims/hypothesis: In addition to weight loss, bariatric surgery for severe obesity dramatically alleviates insulin resistance. In this study, we investigated whether circulating concentrations of the high-molecular-weight (HMW) form of adiponectin are increased following gastric bypass surgery. The HMW form is implicated as the multimer responsible for adiponectin's hepatic insulin-sensitising actions. Subjects and methods: We studied 19 women who were undergoing Roux-en-Y gastric bypass surgery. Studies were conducted prior to, and 1 and 12 months after surgery. Results: One month after surgery, total plasma adiponectin concentrations were unchanged. Nevertheless, increases in both HMW (by 40±15{\%}, p=0.006) and the proportion of adiponectin in the HMW form (from 40±2 to 50±2{\%}, p<0.0001) were observed. At 12 months, total and HMW adiponectin concentrations were increased by 58±8{\%} and 118±21{\%}, respectively (both p<0.001). The majority (80{\%}) of the increase of total adiponectin was due to an increase of the HMW form. After adjustment for covariates, increases of HMW and total adiponectin at 12 months were correlated with the decrease of fat mass (HMW, p=0.0076; total, p=0.0302). In subjects with improved insulin sensitivity at 12 months after surgery (n=18), the increase of HMW, but not that of total adiponectin, predicted the relative decrease of insulin resistance (HMW: p=0.0044; total: p=0.0775, after adjustment for covariates). Conclusions/interpretation: These data suggest that the reduction of fat mass following gastric bypass surgery is an important determinant of the increase of HMW adiponectin concentrations, which in turn is associated with and may contribute to the resulting improvement of insulin sensitivity.",
keywords = "Adiponectin, Clinical science, Gastric bypass, Human, Insulin sensitivity, Weight regulation",
author = "Swarbrick, {M. M.} and Austrheim-Smith, {I. T.} and Kimber Stanhope and {Van Loan}, {M. D.} and Ali, {Mohamed R} and Wolfe, {B. M.} and Havel, {Peter J}",
year = "2006",
month = "11",
doi = "10.1007/s00125-006-0452-8",
language = "English (US)",
volume = "49",
pages = "2552--2558",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer Verlag",
number = "11",

}

TY - JOUR

T1 - Circulating concentrations of high-molecular-weight adiponectin are increased following Roux-en-Y gastric bypass surgery

AU - Swarbrick, M. M.

AU - Austrheim-Smith, I. T.

AU - Stanhope, Kimber

AU - Van Loan, M. D.

AU - Ali, Mohamed R

AU - Wolfe, B. M.

AU - Havel, Peter J

PY - 2006/11

Y1 - 2006/11

N2 - Aims/hypothesis: In addition to weight loss, bariatric surgery for severe obesity dramatically alleviates insulin resistance. In this study, we investigated whether circulating concentrations of the high-molecular-weight (HMW) form of adiponectin are increased following gastric bypass surgery. The HMW form is implicated as the multimer responsible for adiponectin's hepatic insulin-sensitising actions. Subjects and methods: We studied 19 women who were undergoing Roux-en-Y gastric bypass surgery. Studies were conducted prior to, and 1 and 12 months after surgery. Results: One month after surgery, total plasma adiponectin concentrations were unchanged. Nevertheless, increases in both HMW (by 40±15%, p=0.006) and the proportion of adiponectin in the HMW form (from 40±2 to 50±2%, p<0.0001) were observed. At 12 months, total and HMW adiponectin concentrations were increased by 58±8% and 118±21%, respectively (both p<0.001). The majority (80%) of the increase of total adiponectin was due to an increase of the HMW form. After adjustment for covariates, increases of HMW and total adiponectin at 12 months were correlated with the decrease of fat mass (HMW, p=0.0076; total, p=0.0302). In subjects with improved insulin sensitivity at 12 months after surgery (n=18), the increase of HMW, but not that of total adiponectin, predicted the relative decrease of insulin resistance (HMW: p=0.0044; total: p=0.0775, after adjustment for covariates). Conclusions/interpretation: These data suggest that the reduction of fat mass following gastric bypass surgery is an important determinant of the increase of HMW adiponectin concentrations, which in turn is associated with and may contribute to the resulting improvement of insulin sensitivity.

AB - Aims/hypothesis: In addition to weight loss, bariatric surgery for severe obesity dramatically alleviates insulin resistance. In this study, we investigated whether circulating concentrations of the high-molecular-weight (HMW) form of adiponectin are increased following gastric bypass surgery. The HMW form is implicated as the multimer responsible for adiponectin's hepatic insulin-sensitising actions. Subjects and methods: We studied 19 women who were undergoing Roux-en-Y gastric bypass surgery. Studies were conducted prior to, and 1 and 12 months after surgery. Results: One month after surgery, total plasma adiponectin concentrations were unchanged. Nevertheless, increases in both HMW (by 40±15%, p=0.006) and the proportion of adiponectin in the HMW form (from 40±2 to 50±2%, p<0.0001) were observed. At 12 months, total and HMW adiponectin concentrations were increased by 58±8% and 118±21%, respectively (both p<0.001). The majority (80%) of the increase of total adiponectin was due to an increase of the HMW form. After adjustment for covariates, increases of HMW and total adiponectin at 12 months were correlated with the decrease of fat mass (HMW, p=0.0076; total, p=0.0302). In subjects with improved insulin sensitivity at 12 months after surgery (n=18), the increase of HMW, but not that of total adiponectin, predicted the relative decrease of insulin resistance (HMW: p=0.0044; total: p=0.0775, after adjustment for covariates). Conclusions/interpretation: These data suggest that the reduction of fat mass following gastric bypass surgery is an important determinant of the increase of HMW adiponectin concentrations, which in turn is associated with and may contribute to the resulting improvement of insulin sensitivity.

KW - Adiponectin

KW - Clinical science

KW - Gastric bypass

KW - Human

KW - Insulin sensitivity

KW - Weight regulation

UR - http://www.scopus.com/inward/record.url?scp=33749843974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749843974&partnerID=8YFLogxK

U2 - 10.1007/s00125-006-0452-8

DO - 10.1007/s00125-006-0452-8

M3 - Article

C2 - 17019599

AN - SCOPUS:33749843974

VL - 49

SP - 2552

EP - 2558

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 11

ER -