Circulating 25-hydroxyvitamin D levels and frailty in older men

The osteoporotic fractures in men study

Kristine E. Ensrud, Terri L. Blackwell, Jane A. Cauley, Steven R. Cummings, Elizabeth Barrett-Connor, Thuy Tien L Dam, Andrew R. Hoffman, James M. Shikany, Nancy E Lane, Marcia L. Stefanick, Eric S. Orwoll, Peggy M. Cawthon

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES: To determine the cross-sectional and longitudinal associations between 25-hydroxyvitamin D (25(OH)D) levels and frailty status in older men. DESIGN: Prospective cohort study. SETTING: Six U.S. community-based centers. PARTICIPANTS: One thousand six hundred six men aged 65 and older. MEASUREMENTS: 25(OH)D (liquid chromatography tandem mass spectroscopy) and frailty status (criteria similar to those used in the Cardiovascular Health Study) measured at baseline; frailty status assessment repeated an average of 4.6 years later. Frailty status was classified as robust, intermediate, or frail at baseline and robust, intermediate, frail, or dead at follow-up. RESULTS: After adjusting for multiple potential confounders, men with 25(OH)D levels less than 20.0 ng/mL had 1.5 times higher odds (multivariate odds ratio (MOR)=1.47, 95% confidence interval (CI)=1.07-2.02) of greater frailty status at baseline than men with 25(OH)D levels of 30.0 ng/mL or greater (referent group), whereas frailty status was similar in men with 25(OH)D levels from 20.0 to 29.9 ng/mL and those with levels of 30.0 ng/mL or greater (MOR=1.02, 95% CI=0.78-1.32). However, in 1,267 men not classified as frail at baseline, there was no association between lower baseline 25(OH)D level and odds of greater frailty status at the 4.6-year follow-up. Findings were the same when 25(OH)D was expressed in quartiles or as a continuous variable. CONCLUSION: Lower levels of 25(OH)D (<20.0 ng/mL) in community-dwelling older men were independently associated with greater evidence of frailty at baseline but did not predict greater risk of greater frailty status at 4.6 years.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalJournal of the American Geriatrics Society
Volume59
Issue number1
DOIs
StatePublished - Jan 2011

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Osteoporotic Fractures
Odds Ratio
Confidence Intervals
Independent Living
25-hydroxyvitamin D
Liquid Chromatography
Mass Spectrometry
Cohort Studies
Prospective Studies
Health

Keywords

  • 25-hydroxyvitamin D
  • elderly men
  • frailty syndrome

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Ensrud, K. E., Blackwell, T. L., Cauley, J. A., Cummings, S. R., Barrett-Connor, E., Dam, T. T. L., ... Cawthon, P. M. (2011). Circulating 25-hydroxyvitamin D levels and frailty in older men: The osteoporotic fractures in men study. Journal of the American Geriatrics Society, 59(1), 101-106. https://doi.org/10.1111/j.1532-5415.2010.03201.x

Circulating 25-hydroxyvitamin D levels and frailty in older men : The osteoporotic fractures in men study. / Ensrud, Kristine E.; Blackwell, Terri L.; Cauley, Jane A.; Cummings, Steven R.; Barrett-Connor, Elizabeth; Dam, Thuy Tien L; Hoffman, Andrew R.; Shikany, James M.; Lane, Nancy E; Stefanick, Marcia L.; Orwoll, Eric S.; Cawthon, Peggy M.

In: Journal of the American Geriatrics Society, Vol. 59, No. 1, 01.2011, p. 101-106.

Research output: Contribution to journalArticle

Ensrud, KE, Blackwell, TL, Cauley, JA, Cummings, SR, Barrett-Connor, E, Dam, TTL, Hoffman, AR, Shikany, JM, Lane, NE, Stefanick, ML, Orwoll, ES & Cawthon, PM 2011, 'Circulating 25-hydroxyvitamin D levels and frailty in older men: The osteoporotic fractures in men study', Journal of the American Geriatrics Society, vol. 59, no. 1, pp. 101-106. https://doi.org/10.1111/j.1532-5415.2010.03201.x
Ensrud, Kristine E. ; Blackwell, Terri L. ; Cauley, Jane A. ; Cummings, Steven R. ; Barrett-Connor, Elizabeth ; Dam, Thuy Tien L ; Hoffman, Andrew R. ; Shikany, James M. ; Lane, Nancy E ; Stefanick, Marcia L. ; Orwoll, Eric S. ; Cawthon, Peggy M. / Circulating 25-hydroxyvitamin D levels and frailty in older men : The osteoporotic fractures in men study. In: Journal of the American Geriatrics Society. 2011 ; Vol. 59, No. 1. pp. 101-106.
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AU - Cummings, Steven R.

AU - Barrett-Connor, Elizabeth

AU - Dam, Thuy Tien L

AU - Hoffman, Andrew R.

AU - Shikany, James M.

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