Circovirus in tissues of dogs with vasculitis and hemorrhage

Linlin Li, Sabrina McGraw, Kevin Zhu, Christian M. Leutenegger, Stanley L Marks, Steven Kubiski, Patricia Gaffney, Florante N. Dela Cruz, Chunlin Wang, Eric Delwart, Patricia Pesavento

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63 Scopus citations

Abstract

We characterized the complete genome of a novel dog circovirus (DogCV) from the liver of a dog with severe hemorrhagic gastroenteritis, vasculitis, and granulomatous lymphadenitis. DogCV was detected by PCR in fecal samples from 19/168 (11.3%) dogs with diarrhea and 14/204 (6.9%) healthy dogs and in blood from 19/409 (3.3%) of dogs with thrombocytopenia and neutropenia, fever of unknown origin, or past tick bite. Co-infection with other canine pathogens was detected for 13/19 (68%) DogCV-positive dogs with diarrhea. DogCV capsid proteins from different dogs varied by up to 8%. In situ hybridization and transmission electron microscopy detected DogCV in the lymph nodes and spleens of 4 dogs with vascular compromise and histiocytic inflammation. The detection of a circovirus in tissues of dogs expands the known tropism of these viruses to a second mammalian host. Our results indicate that circovirus, alone or in co-infection with other pathogens, might contribute to illness and death in dogs.

Original languageEnglish (US)
Pages (from-to)534-541
Number of pages8
JournalEmerging Infectious Diseases
Volume19
Issue number4
DOIs
StatePublished - Apr 2013

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

Cite this

Li, L., McGraw, S., Zhu, K., Leutenegger, C. M., Marks, S. L., Kubiski, S., Gaffney, P., Dela Cruz, F. N., Wang, C., Delwart, E., & Pesavento, P. (2013). Circovirus in tissues of dogs with vasculitis and hemorrhage. Emerging Infectious Diseases, 19(4), 534-541. https://doi.org/10.3201/eid1904.121390