Circadian rhythms of temperature and activity in obese and lean Zucker rats

D. M. Murakami, Barbara A Horwitz, C. A. Fuller

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


The circadian timing system is important in the regulation of feeding and metabolism, both of which are aberrant in the obese Zucker rat. This study tested the hypothesis that these abnormalities involve a deficit in circadian regulation by examining the circadian rhythms of body temperature and activity in lean and obese Zucker rats exposed to normal light-dark cycles, constant light, and constant dark. Significant deficits in both daily mean and circadian amplitude of temperature and activity were found in obese Zucker female rats relative to lean controls in all lighting conditions. However, the circadian period of obese Zucker rats did not exhibit differences relative to lean controls in either of the constant lighting conditions. These results indicate that although the circadian regulation of temperature and activity in obese Zucker female rats is in fact depressed, obese rats do exhibit normal entrainment and pacemaker functions in the circadian timing system. The results suggest a deficit in the process that generates the amplitude of the circadian rhythm.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number5 38-5
StatePublished - 1995


  • circadian timing system
  • energy balance
  • metabolism
  • suprachiasmatic nucleus

ASJC Scopus subject areas

  • Physiology
  • Agricultural and Biological Sciences(all)


Dive into the research topics of 'Circadian rhythms of temperature and activity in obese and lean Zucker rats'. Together they form a unique fingerprint.

Cite this