Circadian rhythm of corticosterone in diabetic rats

Michelle H. Oster, Thomas W. Castonguay, Carl L Keen, Judith S. Stern

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

We proposed that the circadian rhythm of corticosterone in diabetic rats would have a different pattern than that in non-diabetic control rats. To test this hypothesis, 20 male Sprague-Dawley rats were given ad libitum access to a stock diet and housed individually in a light and temperature controlled room. Ten rats were made diabetic by two subcutaneous injections of streptozotocin. Ten rats which were not injected served as controls. Thirteen days after induction of the diabetes, tail blood samples were taken every 4 h for 24 h. Plasma corticosterone levels were significantly higher in diabetic rats than in control rats at 3 time points during the light cycle; however, concentrations were similar during the dark cycle. We speculate that diabetes may cause alterations in the steroid feedback mechanism to the hypothalamus and/or pituitary, resulting in an abnormal circadian rhythm of plasma corticosterone.

Original languageEnglish (US)
Pages (from-to)1643-1645
Number of pages3
JournalLife Sciences
Volume43
Issue number20
DOIs
StatePublished - 1988

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Corticosterone
Circadian Rhythm
Rats
Rat control
Medical problems
Plasmas
Nutrition
Streptozocin
Photoperiod
Subcutaneous Injections
Blood
Hypothalamus
Steroids
Sprague Dawley Rats
Tail
Feedback
Diet
Light
Temperature

ASJC Scopus subject areas

  • Pharmacology

Cite this

Oster, M. H., Castonguay, T. W., Keen, C. L., & Stern, J. S. (1988). Circadian rhythm of corticosterone in diabetic rats. Life Sciences, 43(20), 1643-1645. https://doi.org/10.1016/0024-3205(88)90536-X

Circadian rhythm of corticosterone in diabetic rats. / Oster, Michelle H.; Castonguay, Thomas W.; Keen, Carl L; Stern, Judith S.

In: Life Sciences, Vol. 43, No. 20, 1988, p. 1643-1645.

Research output: Contribution to journalArticle

Oster, MH, Castonguay, TW, Keen, CL & Stern, JS 1988, 'Circadian rhythm of corticosterone in diabetic rats', Life Sciences, vol. 43, no. 20, pp. 1643-1645. https://doi.org/10.1016/0024-3205(88)90536-X
Oster, Michelle H. ; Castonguay, Thomas W. ; Keen, Carl L ; Stern, Judith S. / Circadian rhythm of corticosterone in diabetic rats. In: Life Sciences. 1988 ; Vol. 43, No. 20. pp. 1643-1645.
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