Circadian rhythm in atopic dermatitis—Pathophysiology and implications for chronotherapy

Alexandra R. Vaughn, Ashley K. Clark, Raja K Sivamani, Vivian Y. Shi

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Circadian rhythm is a biological clock that controls a wide range of physiological functions throughout the body, including various skin functions. A 24-h diurnal cycle, governed by an endogenous clock in the brain, largely controls cutaneous diurnal rhythm, which external factors, including temperature, humidity, diet, and stress, also modulate locally. Circadian rhythm influences cutaneous blood flow and properties of skin barrier function, such as transepidermal water loss and capacitance, and has important implications in atopic dermatitis (AD). This review explores how aberrations in circadian rhythm may play a role in the pathogenesis of AD and proposes implementation of chronotherapy to improve treatment outcomes in patients with AD.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
JournalPediatric Dermatology
Issue number1
StatePublished - Jan 1 2018


  • atopic dermatitis
  • circadian rhythm
  • clock genes
  • eczema
  • skin barrier
  • sleep

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Dermatology


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