CINRG pilot trial of oxatomide in steroid-naïve Duchenne muscular dystrophy

Gunnar M. Buyse, Nathalie Goemans, Erik K Henricson, Alejandro Jara, Marleen van den Hauwe, Robert Leshner, Julaine M. Florence, Jill E. Mayhew, Diana M. Escolar

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The authors report a pilot open-label two-center therapeutic trial of oxatomide in 14 steroid-naive DMD boys aged 5-10 years. Comparison of linear evolutions between 3 months medication-free lead-in periods and 6 months treatment periods showed no significant differences in quantitative (QMT) and manual (MMT) measurements of muscle strength and timed functional tests. A modest mitigation of strength deterioration over time cannot be excluded.

Original languageEnglish (US)
Pages (from-to)337-340
Number of pages4
JournalEuropean Journal of Paediatric Neurology
Volume11
Issue number6
DOIs
StatePublished - Nov 2007
Externally publishedYes

Fingerprint

oxatomide
Duchenne Muscular Dystrophy
Steroids
Muscle Strength
Therapeutics

Keywords

  • Clinical trial
  • Duchenne
  • Muscle
  • Muscular dystrophy
  • Oxatomide
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

CINRG pilot trial of oxatomide in steroid-naïve Duchenne muscular dystrophy. / Buyse, Gunnar M.; Goemans, Nathalie; Henricson, Erik K; Jara, Alejandro; van den Hauwe, Marleen; Leshner, Robert; Florence, Julaine M.; Mayhew, Jill E.; Escolar, Diana M.

In: European Journal of Paediatric Neurology, Vol. 11, No. 6, 11.2007, p. 337-340.

Research output: Contribution to journalArticle

Buyse, GM, Goemans, N, Henricson, EK, Jara, A, van den Hauwe, M, Leshner, R, Florence, JM, Mayhew, JE & Escolar, DM 2007, 'CINRG pilot trial of oxatomide in steroid-naïve Duchenne muscular dystrophy', European Journal of Paediatric Neurology, vol. 11, no. 6, pp. 337-340. https://doi.org/10.1016/j.ejpn.2007.02.009
Buyse, Gunnar M. ; Goemans, Nathalie ; Henricson, Erik K ; Jara, Alejandro ; van den Hauwe, Marleen ; Leshner, Robert ; Florence, Julaine M. ; Mayhew, Jill E. ; Escolar, Diana M. / CINRG pilot trial of oxatomide in steroid-naïve Duchenne muscular dystrophy. In: European Journal of Paediatric Neurology. 2007 ; Vol. 11, No. 6. pp. 337-340.
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