Cingulate lesions and behavioral adaptation to amino acid imbalanced diets

Larry L. Meliza, Philip M.B. Leung, Quinton Rogers

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effect of anterior cingulate cortex lesions on dietary intake and adaptation of disproportionate amounts of amino acids was examined. Rats with bilateral electrolytic lesions in the anterior cingulate cortex and sham-operated rats were fed, in turn, amino acid basal, imbalanced or devoid diets involving threonine and isoleucine as the growth limiting amino acids, and then a low protein (6% casein) followed by a high protein (75% casein) diet. Lesions of the anterior cingulate cortex did not prevent the initial depression in food intake of the amino acid imbalanced diets, but shortened the duration of anorexia associated with dietary amino acid imbalances. Cingulate lesions did not influence the food intake of rats fed amino acid devoid diets. When switched from a low protein to a high protein diet, animals bearing lesions and sham-operated controls reduced markedly their initial food intake and adapted to the high protein diet in similar manner. It was concluded that the initial food intake depression associated with a dietary amino acid imbalance is a direct response to postingestive cues which influence food intake. Moreover, that the difference in adaptive intakes of the cingulate cortex lesioned animals who ingested a diet of imbalanced amino acids or of high protein, indicates that separate mechanisms act to control food intake of animals fed diets containing imbalanced amino acid mixtures or diets with excessive amounts of protein.

Original languageEnglish (US)
Pages (from-to)243-246
Number of pages4
JournalPhysiology and Behavior
Volume30
Issue number2
DOIs
StatePublished - Jan 1 1983

Fingerprint

Diet
Amino Acids
Eating
Gyrus Cinguli
Proteins
Caseins
Depression
Isoleucine
Anorexia
Threonine
Cues
Growth

Keywords

  • Amino acid imbalance
  • Cingulate lesions
  • Food intake
  • Protein

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Cingulate lesions and behavioral adaptation to amino acid imbalanced diets. / Meliza, Larry L.; Leung, Philip M.B.; Rogers, Quinton.

In: Physiology and Behavior, Vol. 30, No. 2, 01.01.1983, p. 243-246.

Research output: Contribution to journalArticle

Meliza, Larry L. ; Leung, Philip M.B. ; Rogers, Quinton. / Cingulate lesions and behavioral adaptation to amino acid imbalanced diets. In: Physiology and Behavior. 1983 ; Vol. 30, No. 2. pp. 243-246.
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