Cilazapril suppresses myointimal proliferation after vascular injury: effects on growth factor induction in vascular smooth muscle cells.

Jerry S Powell, M. Rouge, R. K. Müller, H. R. Baumgartner

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Smooth muscle cell proliferation and formation of extracellular matrix in the intima of muscular arteries after vascular injury can lead to severe intimal hyperplasia and stenosis. Cilazapril reduces intimal hyperplasia induced by balloon catheterization of the rat carotid artery by 80%, and significantly decreases the surface area covered by proliferative lesions. We investigated the effects of angiotensin II (A II) on SMC proliferation in cell culture and A-II induction of selected growth factor or growth-related genes in SMC in culture: PDGF A chain, TGF-beta, thrombospondin, c-myc and c-fos, and compared the influence of cilazapril on these responses to A II. A-II induced SMC proliferation, stimulated mRNAs for c-myc and c-fos after 30 min, and stimulated mRNAs for PDGF A chain, TGF-beta, and thrombospondin somewhat later. The ACE inhibitor did not have detectable independent effects on the A-II induced proliferation or gene expression. Thus, these data support the conclusion that cilazapril suppresses SMC proliferation in vivo through the block of conversion of A I to A II, and that A II has a critical and central role in the control of the proliferative response after balloon catheter-induced vascular injury.

Original languageEnglish (US)
Pages (from-to)65-74
Number of pages10
JournalBasic Research in Cardiology
Volume86 Suppl 1
StatePublished - 1991
Externally publishedYes

Fingerprint

Cilazapril
Vascular System Injuries
Vascular Smooth Muscle
Angiotensin II
Smooth Muscle Myocytes
Intercellular Signaling Peptides and Proteins
Tunica Intima
Thrombospondins
Transforming Growth Factor beta
Hyperplasia
Messenger RNA
Carotid Arteries
Angiotensin-Converting Enzyme Inhibitors
Catheterization
Extracellular Matrix
Pathologic Constriction
Catheters
Arteries
Cell Culture Techniques
Cell Proliferation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cilazapril suppresses myointimal proliferation after vascular injury : effects on growth factor induction in vascular smooth muscle cells. / Powell, Jerry S; Rouge, M.; Müller, R. K.; Baumgartner, H. R.

In: Basic Research in Cardiology, Vol. 86 Suppl 1, 1991, p. 65-74.

Research output: Contribution to journalArticle

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AU - Baumgartner, H. R.

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AB - Smooth muscle cell proliferation and formation of extracellular matrix in the intima of muscular arteries after vascular injury can lead to severe intimal hyperplasia and stenosis. Cilazapril reduces intimal hyperplasia induced by balloon catheterization of the rat carotid artery by 80%, and significantly decreases the surface area covered by proliferative lesions. We investigated the effects of angiotensin II (A II) on SMC proliferation in cell culture and A-II induction of selected growth factor or growth-related genes in SMC in culture: PDGF A chain, TGF-beta, thrombospondin, c-myc and c-fos, and compared the influence of cilazapril on these responses to A II. A-II induced SMC proliferation, stimulated mRNAs for c-myc and c-fos after 30 min, and stimulated mRNAs for PDGF A chain, TGF-beta, and thrombospondin somewhat later. The ACE inhibitor did not have detectable independent effects on the A-II induced proliferation or gene expression. Thus, these data support the conclusion that cilazapril suppresses SMC proliferation in vivo through the block of conversion of A I to A II, and that A II has a critical and central role in the control of the proliferative response after balloon catheter-induced vascular injury.

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