CIITA is not associated with risk of developing rheumatoid arthritis

P. G. Bronson, P. P. Ramsay, Michael F Seldin, P. K. Gregersen, L. A. Criswell, L. F. Barcellos

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The major histocompatibility complex (MHC) class II transactivator gene (CIITA) encodes an important transcription factor regulating genes required for human leukocyte antigen (HLA) class II MHC-restricted antigen presentation. MHC genes, particularly HLA class II, are strongly associated with risk of developing rheumatoid arthritis (RA). Given the strong biological relationship between CIITA and HLA class II genes, a comprehensive investigation of CIITA variation in RA was conducted. This study tested 31 CIITA single-nucleotide polymorphisms in 2542 RA cases and 3690 controls (N=6232). All individuals were of European ancestry, as determined by ancestry informative genetic markers. No evidence for association between CIITA variation and RA was observed after a correction for multiple testing was applied. This is the largest study to fully characterize common genetic variation in CIITA, including an assessment of haplotypes. Results exclude even a modest role for common CIITA polymorphisms in susceptibility to RA.

Original languageEnglish (US)
Pages (from-to)235-238
Number of pages4
JournalGenes and Immunity
Volume12
Issue number3
DOIs
StatePublished - Apr 2011

Fingerprint

MHC Class II Genes
Rheumatoid Arthritis
HLA Antigens
Major Histocompatibility Complex
MHC class II transactivator protein
Antigen Presentation
Genetic Markers
Haplotypes
Genes
Single Nucleotide Polymorphism
Transcription Factors

Keywords

  • autoimmunity
  • CIITA
  • MHC2TA
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

Cite this

Bronson, P. G., Ramsay, P. P., Seldin, M. F., Gregersen, P. K., Criswell, L. A., & Barcellos, L. F. (2011). CIITA is not associated with risk of developing rheumatoid arthritis. Genes and Immunity, 12(3), 235-238. https://doi.org/10.1038/gene.2010.67

CIITA is not associated with risk of developing rheumatoid arthritis. / Bronson, P. G.; Ramsay, P. P.; Seldin, Michael F; Gregersen, P. K.; Criswell, L. A.; Barcellos, L. F.

In: Genes and Immunity, Vol. 12, No. 3, 04.2011, p. 235-238.

Research output: Contribution to journalArticle

Bronson, PG, Ramsay, PP, Seldin, MF, Gregersen, PK, Criswell, LA & Barcellos, LF 2011, 'CIITA is not associated with risk of developing rheumatoid arthritis', Genes and Immunity, vol. 12, no. 3, pp. 235-238. https://doi.org/10.1038/gene.2010.67
Bronson PG, Ramsay PP, Seldin MF, Gregersen PK, Criswell LA, Barcellos LF. CIITA is not associated with risk of developing rheumatoid arthritis. Genes and Immunity. 2011 Apr;12(3):235-238. https://doi.org/10.1038/gene.2010.67
Bronson, P. G. ; Ramsay, P. P. ; Seldin, Michael F ; Gregersen, P. K. ; Criswell, L. A. ; Barcellos, L. F. / CIITA is not associated with risk of developing rheumatoid arthritis. In: Genes and Immunity. 2011 ; Vol. 12, No. 3. pp. 235-238.
@article{1b422a2aff5049a4832b03ea232155d6,
title = "CIITA is not associated with risk of developing rheumatoid arthritis",
abstract = "The major histocompatibility complex (MHC) class II transactivator gene (CIITA) encodes an important transcription factor regulating genes required for human leukocyte antigen (HLA) class II MHC-restricted antigen presentation. MHC genes, particularly HLA class II, are strongly associated with risk of developing rheumatoid arthritis (RA). Given the strong biological relationship between CIITA and HLA class II genes, a comprehensive investigation of CIITA variation in RA was conducted. This study tested 31 CIITA single-nucleotide polymorphisms in 2542 RA cases and 3690 controls (N=6232). All individuals were of European ancestry, as determined by ancestry informative genetic markers. No evidence for association between CIITA variation and RA was observed after a correction for multiple testing was applied. This is the largest study to fully characterize common genetic variation in CIITA, including an assessment of haplotypes. Results exclude even a modest role for common CIITA polymorphisms in susceptibility to RA.",
keywords = "autoimmunity, CIITA, MHC2TA, rheumatoid arthritis",
author = "Bronson, {P. G.} and Ramsay, {P. P.} and Seldin, {Michael F} and Gregersen, {P. K.} and Criswell, {L. A.} and Barcellos, {L. F.}",
year = "2011",
month = "4",
doi = "10.1038/gene.2010.67",
language = "English (US)",
volume = "12",
pages = "235--238",
journal = "Genes and Immunity",
issn = "1466-4879",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - CIITA is not associated with risk of developing rheumatoid arthritis

AU - Bronson, P. G.

AU - Ramsay, P. P.

AU - Seldin, Michael F

AU - Gregersen, P. K.

AU - Criswell, L. A.

AU - Barcellos, L. F.

PY - 2011/4

Y1 - 2011/4

N2 - The major histocompatibility complex (MHC) class II transactivator gene (CIITA) encodes an important transcription factor regulating genes required for human leukocyte antigen (HLA) class II MHC-restricted antigen presentation. MHC genes, particularly HLA class II, are strongly associated with risk of developing rheumatoid arthritis (RA). Given the strong biological relationship between CIITA and HLA class II genes, a comprehensive investigation of CIITA variation in RA was conducted. This study tested 31 CIITA single-nucleotide polymorphisms in 2542 RA cases and 3690 controls (N=6232). All individuals were of European ancestry, as determined by ancestry informative genetic markers. No evidence for association between CIITA variation and RA was observed after a correction for multiple testing was applied. This is the largest study to fully characterize common genetic variation in CIITA, including an assessment of haplotypes. Results exclude even a modest role for common CIITA polymorphisms in susceptibility to RA.

AB - The major histocompatibility complex (MHC) class II transactivator gene (CIITA) encodes an important transcription factor regulating genes required for human leukocyte antigen (HLA) class II MHC-restricted antigen presentation. MHC genes, particularly HLA class II, are strongly associated with risk of developing rheumatoid arthritis (RA). Given the strong biological relationship between CIITA and HLA class II genes, a comprehensive investigation of CIITA variation in RA was conducted. This study tested 31 CIITA single-nucleotide polymorphisms in 2542 RA cases and 3690 controls (N=6232). All individuals were of European ancestry, as determined by ancestry informative genetic markers. No evidence for association between CIITA variation and RA was observed after a correction for multiple testing was applied. This is the largest study to fully characterize common genetic variation in CIITA, including an assessment of haplotypes. Results exclude even a modest role for common CIITA polymorphisms in susceptibility to RA.

KW - autoimmunity

KW - CIITA

KW - MHC2TA

KW - rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=79955479297&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955479297&partnerID=8YFLogxK

U2 - 10.1038/gene.2010.67

DO - 10.1038/gene.2010.67

M3 - Article

C2 - 21248776

AN - SCOPUS:79955479297

VL - 12

SP - 235

EP - 238

JO - Genes and Immunity

JF - Genes and Immunity

SN - 1466-4879

IS - 3

ER -