CIITA is not associated with risk of developing rheumatoid arthritis

P. G. Bronson, P. P. Ramsay, Michael F Seldin, P. K. Gregersen, L. A. Criswell, L. F. Barcellos

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The major histocompatibility complex (MHC) class II transactivator gene (CIITA) encodes an important transcription factor regulating genes required for human leukocyte antigen (HLA) class II MHC-restricted antigen presentation. MHC genes, particularly HLA class II, are strongly associated with risk of developing rheumatoid arthritis (RA). Given the strong biological relationship between CIITA and HLA class II genes, a comprehensive investigation of CIITA variation in RA was conducted. This study tested 31 CIITA single-nucleotide polymorphisms in 2542 RA cases and 3690 controls (N=6232). All individuals were of European ancestry, as determined by ancestry informative genetic markers. No evidence for association between CIITA variation and RA was observed after a correction for multiple testing was applied. This is the largest study to fully characterize common genetic variation in CIITA, including an assessment of haplotypes. Results exclude even a modest role for common CIITA polymorphisms in susceptibility to RA.

Original languageEnglish (US)
Pages (from-to)235-238
Number of pages4
JournalGenes and Immunity
Issue number3
StatePublished - Apr 2011


  • autoimmunity
  • MHC2TA
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics


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