Cigarette smoke increases gastric ulcer size in part by an angiotensin II-mediated mechanism in rats

Kyoji Seno, Jian H. Zhu, Jack D. Barrett, Peter Eggena, Oscar U. Scremin, Kan Lam, Joseph W C Leung, Felix W. Leung

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To assess the mechanism of the effect of cigarette smoke on ulcer disease we employed a rat model in which cigarette smoke increases the size of acetic acid-induced gastric ulcer and decreases the hyperemia at the ulcer margin. We postulate that cigarette smoke increases angiotensin II (a vasoconstrictor) in ulcer tissue. Since direct measurement of angiotensin II in small tissue samples is problematic, we compared the messenger ribonucleic acid (mRNA) for its precursors (angiotensinogen and renin) in ulcer and normal gastric tissue. We also evaluated the effect of enalapril, which blocks the conversion of angiotensin I to angiotensin II on ulcer size. In the ulcer tissue, cigarette smoke produced a significant increase in mRNA for angiotensinogen but not for renin. Enalapril decreased the size of the gastric ulcer in rats exposed to cigarette smoke. The data support the possibility that in ulcer tissue cigarette smoke stimulates an angiotensin II-mediated mechanism, which may in part be responsible for the impairment of ulcer margin hyperemia and aggravation of ulcer size.

Original languageEnglish (US)
Pages (from-to)74-78
Number of pages5
JournalDigestive Diseases and Sciences
Volume42
Issue number1
DOIs
StatePublished - 1997

Fingerprint

Stomach Ulcer
Smoke
Tobacco Products
Angiotensin II
Ulcer
Angiotensinogen
Enalapril
Hyperemia
Renin
RNA
Angiotensin I
Vasoconstrictor Agents
Acetic Acid

Keywords

  • angiotensin converting-enzyme inhibitor
  • angiotensinogen
  • gastric hyperemia
  • growth factor

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Seno, K., Zhu, J. H., Barrett, J. D., Eggena, P., Scremin, O. U., Lam, K., ... Leung, F. W. (1997). Cigarette smoke increases gastric ulcer size in part by an angiotensin II-mediated mechanism in rats. Digestive Diseases and Sciences, 42(1), 74-78. https://doi.org/10.1023/A:1018880904201

Cigarette smoke increases gastric ulcer size in part by an angiotensin II-mediated mechanism in rats. / Seno, Kyoji; Zhu, Jian H.; Barrett, Jack D.; Eggena, Peter; Scremin, Oscar U.; Lam, Kan; Leung, Joseph W C; Leung, Felix W.

In: Digestive Diseases and Sciences, Vol. 42, No. 1, 1997, p. 74-78.

Research output: Contribution to journalArticle

Seno, Kyoji ; Zhu, Jian H. ; Barrett, Jack D. ; Eggena, Peter ; Scremin, Oscar U. ; Lam, Kan ; Leung, Joseph W C ; Leung, Felix W. / Cigarette smoke increases gastric ulcer size in part by an angiotensin II-mediated mechanism in rats. In: Digestive Diseases and Sciences. 1997 ; Vol. 42, No. 1. pp. 74-78.
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