Cicatricial Alopecia Research Foundation meeting, May 2016: Progress towards the diagnosis, treatment and cure of primary cicatricial alopecias

John P. Sundberg, Maria K. Hordinsky, Wilma Bergfeld, Yolanda M. Lenzy, Amy J. McMichael, Angela M. Christiano, Tracy McGregor, Kurt S. Stenn, Raja K Sivamani, Craig Herbert Pratt, Lloyd E. King

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Primary cicatricial alopecias (PCAs) are a group of skin diseases in which there is progressive and permanent destruction of hair follicles followed by replacement with fibrous tissue. Unfortunately, by the time patients seek clinical evaluation of their hair loss, the skin is already inflamed and/or scarred, so there is little hope for a return to their normal hair growth pattern. Clinical and basic science investigations are now focusing on three forms of human PCA: lichen planopilaris (LPP), frontal fibrosing alopecia (FFA) and central centrifugal cicatricial alopecia (CCCA). Transcriptome, lipidome and other new technologies are providing new insight into the pathogenesis of some of these diseases that are being validated and further investigated using spontaneous and genetically engineered mouse models.

Original languageEnglish (US)
Pages (from-to)302-310
Number of pages9
JournalExperimental Dermatology
Volume27
Issue number3
DOIs
StatePublished - Mar 1 2018

Keywords

  • animal models
  • BioVU
  • central centrifugal cicatricial alopecia
  • frontal fibrosing alopecia
  • lichen planopilaris
  • primary cicatricial alopecias

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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    Sundberg, J. P., Hordinsky, M. K., Bergfeld, W., Lenzy, Y. M., McMichael, A. J., Christiano, A. M., McGregor, T., Stenn, K. S., Sivamani, R. K., Pratt, C. H., & King, L. E. (2018). Cicatricial Alopecia Research Foundation meeting, May 2016: Progress towards the diagnosis, treatment and cure of primary cicatricial alopecias. Experimental Dermatology, 27(3), 302-310. https://doi.org/10.1111/exd.13495