Abstract
The effects of chronic theophylline treatment on brain adenosine A1 receptors and amygdala-kindled seizures were examined in rats. The repeated administration of theophylline 417 μmoles/kg/day i.p. (75 mg/kg/day) for 14 days resulted in a significant increase in 1 nM [3H]cyclohexyladenosine binding to adenosine A1 receptors in thalamus, hippocampus, and cerebellum. This chronic theophylline treatment was shown to significantly prolong the immediate postseizure refractory period (defined as sensitivity to a subsequent kindling stimulation) while both the severity and duration of an initial kindled seizure was not affected. These findings indicate that the postseizure refractory period can be influenced by the brain adenosine system, and implicate adenosine as an important neuromodulator of the patterning of seizure episodes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 287-291 |
| Number of pages | 5 |
| Journal | Drug Development Research |
| Volume | 29 |
| Issue number | 4 |
| State | Published - 1993 |
| Externally published | Yes |
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Keywords
- adenosine A receptor
- amygdala
- kindling
- theophylline
- up-regulation
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery
- Pharmacology
Cite this
Chronic theophylline prolongs the refractory period in amygdala-kindled rats. / Kleinsorge, R. J.; Bowers, L. M.; Jarvis, M. F.; Berman, Robert F.
In: Drug Development Research, Vol. 29, No. 4, 1993, p. 287-291.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic theophylline prolongs the refractory period in amygdala-kindled rats
AU - Kleinsorge, R. J.
AU - Bowers, L. M.
AU - Jarvis, M. F.
AU - Berman, Robert F
PY - 1993
Y1 - 1993
N2 - The effects of chronic theophylline treatment on brain adenosine A1 receptors and amygdala-kindled seizures were examined in rats. The repeated administration of theophylline 417 μmoles/kg/day i.p. (75 mg/kg/day) for 14 days resulted in a significant increase in 1 nM [3H]cyclohexyladenosine binding to adenosine A1 receptors in thalamus, hippocampus, and cerebellum. This chronic theophylline treatment was shown to significantly prolong the immediate postseizure refractory period (defined as sensitivity to a subsequent kindling stimulation) while both the severity and duration of an initial kindled seizure was not affected. These findings indicate that the postseizure refractory period can be influenced by the brain adenosine system, and implicate adenosine as an important neuromodulator of the patterning of seizure episodes.
AB - The effects of chronic theophylline treatment on brain adenosine A1 receptors and amygdala-kindled seizures were examined in rats. The repeated administration of theophylline 417 μmoles/kg/day i.p. (75 mg/kg/day) for 14 days resulted in a significant increase in 1 nM [3H]cyclohexyladenosine binding to adenosine A1 receptors in thalamus, hippocampus, and cerebellum. This chronic theophylline treatment was shown to significantly prolong the immediate postseizure refractory period (defined as sensitivity to a subsequent kindling stimulation) while both the severity and duration of an initial kindled seizure was not affected. These findings indicate that the postseizure refractory period can be influenced by the brain adenosine system, and implicate adenosine as an important neuromodulator of the patterning of seizure episodes.
KW - adenosine A receptor
KW - amygdala
KW - kindling
KW - theophylline
KW - up-regulation
UR - http://www.scopus.com/inward/record.url?scp=0027202316&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027202316&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0027202316
VL - 29
SP - 287
EP - 291
JO - Drug Development Research
JF - Drug Development Research
SN - 0272-4391
IS - 4
ER -