Chronic progressive nephropathy in aging rats

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29 Scopus citations


Chronic progressive nephropathy (CPN) is a commonly encountered lesion in aging laboratory rats. CPN has been given a variety of names, based upon its complex nature. It is a lesion that occurs primarily in albino strains and is influenced not only by genetics but also by sex, age, hormones, diet, and microflora, among other factors. Affected kidneys are enlarged, pale and finely indented. The lesion begins with progressive thickening of glomerular, Bowman's capsular and proximal tubular basement membranes. Mesangial matrix increases with deposition of IgM and, to a lesser extent, other serum components. Tubular atrophy and degenerative changes occur as the lesion progresses. The disease is manifested by increasingly non-selective proteinure, consisting mainly of albumin. Serum chemical changes include elevations in α globulins and cholesterol and a decrease in albumin. Creatine and urea remain unchanged until late in the course of CPN. Renal secondary hyperparathyroidism may occasionally be seen.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalToxicologic Pathology
Issue number1
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Pathology and Forensic Medicine
  • Toxicology


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