Chronic obstructive pulmonary disease mortality in diesel-exposed railroad workers

Jaime E. Hart, Francine Laden, Marc B Schenker, Eric Garshick

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Diesel exhaust is a mixture of combustion gases and ultrafine particles coated with organic compounds. There is concern whether exposure can result in or worsen obstructive airway diseases, but there is only limited information to assess this risk. U.S. railroad workers have been exposed to diesel exhaust since diesel locomotives were introduced after World War II, and by 1959, 95% of the locomotives were diesel. We conducted a case-control study of railroad worker deaths between 1981 and 1982 using U.S. Railroad Retirement Board job records and next-of-kin smoking, residential, and vitamin use histories. There were 536 cases with chronic obstructive pulmonary disease (COPD) and 1,525 controls with causes of death not related to diesel exhaust or fine particle exposure. After adjustment for age, race, smoking, U.S. Census region of death, vitamin use, and total years off work, engineers and conductors with diesel-exhaust exposure from operating trains had an increased risk of COPD mortality. The odds of COPD mortality increased with years of work in these jobs, and those who had worked ≥ 16 years as an engineer or conductor after 1959 had an odds ratio of 1.61 (95% confidence interval, 1.12-2.30). These results suggest that diesel-exhaust exposure contributed to COPD mortality in these workers. Further study is needed to assess whether this risk is observed after exposure to exhaust from later-generation diesel engines with modern emission controls.

Original languageEnglish (US)
Pages (from-to)1013-1017
Number of pages5
JournalEnvironmental Health Perspectives
Volume114
Issue number7
DOIs
StatePublished - Jul 2006

Fingerprint

Railroads
Vehicle Emissions
Pulmonary diseases
Chronic Obstructive Pulmonary Disease
diesel
mortality
Mortality
Diesel locomotives
Vitamins
Smoking
vitamin
smoking
Engineers
World War II
Retirement
Emission control
Censuses
Organic compounds
Diesel engines
Case-Control Studies

Keywords

  • Chronic obstructive pulmonary disease
  • COPD
  • Nonmalignant respiratory disease
  • Occupational exposure
  • Vehicle emissions

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Chronic obstructive pulmonary disease mortality in diesel-exposed railroad workers. / Hart, Jaime E.; Laden, Francine; Schenker, Marc B; Garshick, Eric.

In: Environmental Health Perspectives, Vol. 114, No. 7, 07.2006, p. 1013-1017.

Research output: Contribution to journalArticle

Hart, Jaime E. ; Laden, Francine ; Schenker, Marc B ; Garshick, Eric. / Chronic obstructive pulmonary disease mortality in diesel-exposed railroad workers. In: Environmental Health Perspectives. 2006 ; Vol. 114, No. 7. pp. 1013-1017.
@article{4f0a13c3a059416d970e2e1775cdcd94,
title = "Chronic obstructive pulmonary disease mortality in diesel-exposed railroad workers",
abstract = "Diesel exhaust is a mixture of combustion gases and ultrafine particles coated with organic compounds. There is concern whether exposure can result in or worsen obstructive airway diseases, but there is only limited information to assess this risk. U.S. railroad workers have been exposed to diesel exhaust since diesel locomotives were introduced after World War II, and by 1959, 95{\%} of the locomotives were diesel. We conducted a case-control study of railroad worker deaths between 1981 and 1982 using U.S. Railroad Retirement Board job records and next-of-kin smoking, residential, and vitamin use histories. There were 536 cases with chronic obstructive pulmonary disease (COPD) and 1,525 controls with causes of death not related to diesel exhaust or fine particle exposure. After adjustment for age, race, smoking, U.S. Census region of death, vitamin use, and total years off work, engineers and conductors with diesel-exhaust exposure from operating trains had an increased risk of COPD mortality. The odds of COPD mortality increased with years of work in these jobs, and those who had worked ≥ 16 years as an engineer or conductor after 1959 had an odds ratio of 1.61 (95{\%} confidence interval, 1.12-2.30). These results suggest that diesel-exhaust exposure contributed to COPD mortality in these workers. Further study is needed to assess whether this risk is observed after exposure to exhaust from later-generation diesel engines with modern emission controls.",
keywords = "Chronic obstructive pulmonary disease, COPD, Nonmalignant respiratory disease, Occupational exposure, Vehicle emissions",
author = "Hart, {Jaime E.} and Francine Laden and Schenker, {Marc B} and Eric Garshick",
year = "2006",
month = "7",
doi = "10.1289/ehp.8743",
language = "English (US)",
volume = "114",
pages = "1013--1017",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "Public Health Services, US Dept of Health and Human Services",
number = "7",

}

TY - JOUR

T1 - Chronic obstructive pulmonary disease mortality in diesel-exposed railroad workers

AU - Hart, Jaime E.

AU - Laden, Francine

AU - Schenker, Marc B

AU - Garshick, Eric

PY - 2006/7

Y1 - 2006/7

N2 - Diesel exhaust is a mixture of combustion gases and ultrafine particles coated with organic compounds. There is concern whether exposure can result in or worsen obstructive airway diseases, but there is only limited information to assess this risk. U.S. railroad workers have been exposed to diesel exhaust since diesel locomotives were introduced after World War II, and by 1959, 95% of the locomotives were diesel. We conducted a case-control study of railroad worker deaths between 1981 and 1982 using U.S. Railroad Retirement Board job records and next-of-kin smoking, residential, and vitamin use histories. There were 536 cases with chronic obstructive pulmonary disease (COPD) and 1,525 controls with causes of death not related to diesel exhaust or fine particle exposure. After adjustment for age, race, smoking, U.S. Census region of death, vitamin use, and total years off work, engineers and conductors with diesel-exhaust exposure from operating trains had an increased risk of COPD mortality. The odds of COPD mortality increased with years of work in these jobs, and those who had worked ≥ 16 years as an engineer or conductor after 1959 had an odds ratio of 1.61 (95% confidence interval, 1.12-2.30). These results suggest that diesel-exhaust exposure contributed to COPD mortality in these workers. Further study is needed to assess whether this risk is observed after exposure to exhaust from later-generation diesel engines with modern emission controls.

AB - Diesel exhaust is a mixture of combustion gases and ultrafine particles coated with organic compounds. There is concern whether exposure can result in or worsen obstructive airway diseases, but there is only limited information to assess this risk. U.S. railroad workers have been exposed to diesel exhaust since diesel locomotives were introduced after World War II, and by 1959, 95% of the locomotives were diesel. We conducted a case-control study of railroad worker deaths between 1981 and 1982 using U.S. Railroad Retirement Board job records and next-of-kin smoking, residential, and vitamin use histories. There were 536 cases with chronic obstructive pulmonary disease (COPD) and 1,525 controls with causes of death not related to diesel exhaust or fine particle exposure. After adjustment for age, race, smoking, U.S. Census region of death, vitamin use, and total years off work, engineers and conductors with diesel-exhaust exposure from operating trains had an increased risk of COPD mortality. The odds of COPD mortality increased with years of work in these jobs, and those who had worked ≥ 16 years as an engineer or conductor after 1959 had an odds ratio of 1.61 (95% confidence interval, 1.12-2.30). These results suggest that diesel-exhaust exposure contributed to COPD mortality in these workers. Further study is needed to assess whether this risk is observed after exposure to exhaust from later-generation diesel engines with modern emission controls.

KW - Chronic obstructive pulmonary disease

KW - COPD

KW - Nonmalignant respiratory disease

KW - Occupational exposure

KW - Vehicle emissions

UR - http://www.scopus.com/inward/record.url?scp=33745792763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745792763&partnerID=8YFLogxK

U2 - 10.1289/ehp.8743

DO - 10.1289/ehp.8743

M3 - Article

C2 - 16835052

AN - SCOPUS:33745792763

VL - 114

SP - 1013

EP - 1017

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 7

ER -