Chronic myelodysplastic syndrome (preleukemia) with the Philadelphia chromosome

D. G. Roth, Carol M Richman, J. D. Rowley

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A patient with severe anemia, reticulocytopenia, and erythroid hyperplasia of the bone marrow developed fatal acute nonlymphocytic leukemia after 3 yr. A Philadelphia chromosome with the typical 9/22 translocation t(9q+;22q-) was identified by banding techniques in a small number of bone marrow cells throughout the preleukemic phase of the illness (14%-38% of metaphases) and during the acute transformation (50%). Granulocytic colony formation in vitro was abnormal in the preleukemic phase. The diagnosis of chronic granulocytic leukemia was excluded on the basis of clinical and laboratory findings. The identification of the Philadelphia chromosome in this form of chronic myelodysplastic syndrome (preleukemia) provides a new example of a hematologic disorder predisposing to acute leukemia in which this chromosomal abnormality occurs.

Original languageEnglish (US)
Pages (from-to)262-264
Number of pages3
JournalBlood
Volume56
Issue number2
StatePublished - 1980
Externally publishedYes

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Preleukemia
Philadelphia Chromosome
Myelodysplastic Syndromes
Chromosomes
Bone
Metaphase
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Acute Myeloid Leukemia
Chromosome Aberrations
Bone Marrow Cells
Hyperplasia
Anemia
Leukemia
Bone Marrow
Cells

ASJC Scopus subject areas

  • Hematology

Cite this

Chronic myelodysplastic syndrome (preleukemia) with the Philadelphia chromosome. / Roth, D. G.; Richman, Carol M; Rowley, J. D.

In: Blood, Vol. 56, No. 2, 1980, p. 262-264.

Research output: Contribution to journalArticle

Roth, D. G. ; Richman, Carol M ; Rowley, J. D. / Chronic myelodysplastic syndrome (preleukemia) with the Philadelphia chromosome. In: Blood. 1980 ; Vol. 56, No. 2. pp. 262-264.
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