Abstract
Objective - To determine whether ingestion of 63 times the recommended amount of vitamin D3 (cholecalciferol) results in renal calcification or damage in cats. Animals - 20 four-month-old kittens, 17 queens, and 20 kittens born to these queens. Procedure - 4-month-old kittens and queens were given a purified diet with 846 μg of cholecalciferol/kg of diet (high vitamin D3 diet) or 118 μg of cholecalciferol/kg of diet (control diet) for 18 months. Kittens born to queens were weaned onto the same diet given to dams. Results - There were no apparent adverse effects of the high vitamin D3 diet. Plasma cholecalciferol and 25-hydroxycholecalciferol (25-OHD3) concentrations of queens and 4-month-old kittens given the high vitamin D3 diet significantly increased with time. At 6 months, plasma cholecalciferol concentrations in these kittens and queens were 140.0 ± 7.3 nmol/L and 423.6 ± 26.6 nmol/L, respectively (10 times initial values). Corresponding 25-OHD3 concentration in queens was 587.5 ± 59.4 nmol/L (2.5-fold increase over initial values). At 3 months of age, kittens born to queens given the high vitamin D3 diet had an increase in serum BUN and calcium concentrations and a decrease in RBC and serum total protein, albumin, and hemoglobin concentrations. By 18 months, these kittens had an increase in plasma cholecalciferol (276.0 ± 22.2 nmol/L) and 25-OHD3 (1,071.9 ± 115.3 nmol/L) concentrations. However, all indices of renal function and the appearance of renal tissue on histologic evaluation were normal. Conclusions and Clinical Relevance - These results indicate that cats are resistant to cholecalciferol toxicosis when the diet is otherwise complete and balanced.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1500-1506 |
| Number of pages | 7 |
| Journal | American Journal of Veterinary Research |
| Volume | 62 |
| Issue number | 9 |
| DOIs | |
| State | Published - Jan 1 2001 |
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Chronic ingestion of high concentrations of cholecalciferol in cats. / Sih, Tracey R.; Morris, James; Hickman, M. Anne.
In: American Journal of Veterinary Research, Vol. 62, No. 9, 01.01.2001, p. 1500-1506.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic ingestion of high concentrations of cholecalciferol in cats
AU - Sih, Tracey R.
AU - Morris, James
AU - Hickman, M. Anne
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Objective - To determine whether ingestion of 63 times the recommended amount of vitamin D3 (cholecalciferol) results in renal calcification or damage in cats. Animals - 20 four-month-old kittens, 17 queens, and 20 kittens born to these queens. Procedure - 4-month-old kittens and queens were given a purified diet with 846 μg of cholecalciferol/kg of diet (high vitamin D3 diet) or 118 μg of cholecalciferol/kg of diet (control diet) for 18 months. Kittens born to queens were weaned onto the same diet given to dams. Results - There were no apparent adverse effects of the high vitamin D3 diet. Plasma cholecalciferol and 25-hydroxycholecalciferol (25-OHD3) concentrations of queens and 4-month-old kittens given the high vitamin D3 diet significantly increased with time. At 6 months, plasma cholecalciferol concentrations in these kittens and queens were 140.0 ± 7.3 nmol/L and 423.6 ± 26.6 nmol/L, respectively (10 times initial values). Corresponding 25-OHD3 concentration in queens was 587.5 ± 59.4 nmol/L (2.5-fold increase over initial values). At 3 months of age, kittens born to queens given the high vitamin D3 diet had an increase in serum BUN and calcium concentrations and a decrease in RBC and serum total protein, albumin, and hemoglobin concentrations. By 18 months, these kittens had an increase in plasma cholecalciferol (276.0 ± 22.2 nmol/L) and 25-OHD3 (1,071.9 ± 115.3 nmol/L) concentrations. However, all indices of renal function and the appearance of renal tissue on histologic evaluation were normal. Conclusions and Clinical Relevance - These results indicate that cats are resistant to cholecalciferol toxicosis when the diet is otherwise complete and balanced.
AB - Objective - To determine whether ingestion of 63 times the recommended amount of vitamin D3 (cholecalciferol) results in renal calcification or damage in cats. Animals - 20 four-month-old kittens, 17 queens, and 20 kittens born to these queens. Procedure - 4-month-old kittens and queens were given a purified diet with 846 μg of cholecalciferol/kg of diet (high vitamin D3 diet) or 118 μg of cholecalciferol/kg of diet (control diet) for 18 months. Kittens born to queens were weaned onto the same diet given to dams. Results - There were no apparent adverse effects of the high vitamin D3 diet. Plasma cholecalciferol and 25-hydroxycholecalciferol (25-OHD3) concentrations of queens and 4-month-old kittens given the high vitamin D3 diet significantly increased with time. At 6 months, plasma cholecalciferol concentrations in these kittens and queens were 140.0 ± 7.3 nmol/L and 423.6 ± 26.6 nmol/L, respectively (10 times initial values). Corresponding 25-OHD3 concentration in queens was 587.5 ± 59.4 nmol/L (2.5-fold increase over initial values). At 3 months of age, kittens born to queens given the high vitamin D3 diet had an increase in serum BUN and calcium concentrations and a decrease in RBC and serum total protein, albumin, and hemoglobin concentrations. By 18 months, these kittens had an increase in plasma cholecalciferol (276.0 ± 22.2 nmol/L) and 25-OHD3 (1,071.9 ± 115.3 nmol/L) concentrations. However, all indices of renal function and the appearance of renal tissue on histologic evaluation were normal. Conclusions and Clinical Relevance - These results indicate that cats are resistant to cholecalciferol toxicosis when the diet is otherwise complete and balanced.
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U2 - 10.2460/ajvr.2001.62.1500
DO - 10.2460/ajvr.2001.62.1500
M3 - Article
VL - 62
SP - 1500
EP - 1506
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
SN - 0002-9645
IS - 9
ER -