Chronic femoral artery occlusion augments exercise pressor reflex in decerebrated rats

Hirotsugu Tsuchimochi, Jennifer L. McCord, Shawn G. Hayes, Satoshi Koba, Marc P Kaufman

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

In decerebrated rats, we determined the pressor and cardioaccelerator reflex responses to static contraction of hindlimb muscles whose femoral arteries were either occluded 72 h before contraction, occluded 3 min before contraction, or freely perfused. We found that the pressor reflex arising from the limb whose femoral artery was occluded for 72 h before contraction (32 ± 5 mmHg, n = 16) was significantly higher than the pressor reflex arising from the contralateral freely perfused limb (15 ± 3 mmHg, n = 16, P < 0.001) or than that arising from the contralateral limb whose femoral artery was occluded for only 3 min (17 ± 4 mmHg, n = 16, P < 0.001). Moreover, the pressor reflex arising from the limb whose femoral artery was occluded for 3 min before the start of contraction was not significantly different than that arising from the contralateral freely perfused limb (n = 16, P = 0.819). The pressor component of the reflex arising from the limb whose femoral artery was occluded for 72 h was not changed by transient receptor potential vanilloid (TRPV) 1 receptor blockade with iodo-resiniferatoxin (n = 15, P = 0.272), although the cardioaccelerator component was significantly reduced (P = 0.005). In addition, the pressor response evoked by capsaicin injection in the femoral artery of the 72-h occluded limb was more than double that evoked from the freely perfused limb (P = 0.026). We conclude that chronic (i.e., 72 h) but not acute (3 min), femoral arterial occlusion augments pressor reflex arising from contraction of hindlimb muscles and that TRPV1 receptors play little role in this augmentation.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume299
Issue number1
DOIs
StatePublished - Jul 2010
Externally publishedYes

Fingerprint

Femoral Artery
Reflex
Extremities
Hindlimb
Muscle Contraction
Capsaicin
Thigh
Injections

Keywords

  • Ischemia
  • Neural control of circulation
  • Static contraction
  • Thin fiber muscle afferents

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Chronic femoral artery occlusion augments exercise pressor reflex in decerebrated rats. / Tsuchimochi, Hirotsugu; McCord, Jennifer L.; Hayes, Shawn G.; Koba, Satoshi; Kaufman, Marc P.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 299, No. 1, 07.2010.

Research output: Contribution to journalArticle

Tsuchimochi, Hirotsugu ; McCord, Jennifer L. ; Hayes, Shawn G. ; Koba, Satoshi ; Kaufman, Marc P. / Chronic femoral artery occlusion augments exercise pressor reflex in decerebrated rats. In: American Journal of Physiology - Heart and Circulatory Physiology. 2010 ; Vol. 299, No. 1.
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