Chronic eosinophilic dermatitis associated with persistent feline herpes virus infection in cheetahs (Acinonyx jubatus)

L. Munson, R. Wack, M. Duncan, R. J. Montali, D. Boon, I. Stalis, G. J. Crawshaw, K. N. Cameron, J. Mortenson, S. Citino, J. Zuba, R. E. Junge

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A chronic ulcerative and eosinophilic dermatitis occurred in 20 captive cheetahs (Acinonyx jubatus) with persistent feline herpes virus 1 (FHV1) infection. Affected animals had erythematous, ulcerated plaques primarily on the face and forelegs in sites of contact with lachrymal and salivary secretions. The dermatitis was characterized by dense infiltrates of eosinophils and plasma cells and pseudoepitheliomatous hyperplasia. Rare keratinocytes within the lesions had nuclei with marginated chromatin and small eosinophilic inclusions composed of herpes virus nucleocapsids. Virus isolated from lesions was confirmed to be FHV1. Lesions persisted and progressed unless removed by cryoexcision. The occurrence of this unusual reaction to FHV1 in approximately 5% of captive North American cheetahs suggests a species propensity for a Th2-dominant response to herpes virus infection. This atypical immune reaction may indicate a heritable trait or modulation of the immune response by other factors such as chronic stress.

Original languageEnglish (US)
Pages (from-to)170-176
Number of pages7
JournalVeterinary Pathology
Volume41
Issue number2
DOIs
StatePublished - Mar 2004

Fingerprint

Acinonyx
Acinonyx jubatus
Felidae
Dermatitis
Virus Diseases
dermatitis
cats
Viruses
viruses
lesions (animal)
infection
Nucleocapsid
Plasma Cells
Keratinocytes
Eosinophils
Chromatin
Hyperplasia
nucleocapsid
plasma cells
keratinocytes

Keywords

  • Acinonyx jubatus
  • Cheetahs
  • Dermatitis
  • Eosinophils
  • Feline herpes virus 1
  • Pseudoepitheliomatous hyperplasia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Munson, L., Wack, R., Duncan, M., Montali, R. J., Boon, D., Stalis, I., ... Junge, R. E. (2004). Chronic eosinophilic dermatitis associated with persistent feline herpes virus infection in cheetahs (Acinonyx jubatus). Veterinary Pathology, 41(2), 170-176. https://doi.org/10.1354/vp.41-2-170

Chronic eosinophilic dermatitis associated with persistent feline herpes virus infection in cheetahs (Acinonyx jubatus). / Munson, L.; Wack, R.; Duncan, M.; Montali, R. J.; Boon, D.; Stalis, I.; Crawshaw, G. J.; Cameron, K. N.; Mortenson, J.; Citino, S.; Zuba, J.; Junge, R. E.

In: Veterinary Pathology, Vol. 41, No. 2, 03.2004, p. 170-176.

Research output: Contribution to journalArticle

Munson, L, Wack, R, Duncan, M, Montali, RJ, Boon, D, Stalis, I, Crawshaw, GJ, Cameron, KN, Mortenson, J, Citino, S, Zuba, J & Junge, RE 2004, 'Chronic eosinophilic dermatitis associated with persistent feline herpes virus infection in cheetahs (Acinonyx jubatus)', Veterinary Pathology, vol. 41, no. 2, pp. 170-176. https://doi.org/10.1354/vp.41-2-170
Munson, L. ; Wack, R. ; Duncan, M. ; Montali, R. J. ; Boon, D. ; Stalis, I. ; Crawshaw, G. J. ; Cameron, K. N. ; Mortenson, J. ; Citino, S. ; Zuba, J. ; Junge, R. E. / Chronic eosinophilic dermatitis associated with persistent feline herpes virus infection in cheetahs (Acinonyx jubatus). In: Veterinary Pathology. 2004 ; Vol. 41, No. 2. pp. 170-176.
@article{06ff22ceec074f2fb85c9d31c57b1066,
title = "Chronic eosinophilic dermatitis associated with persistent feline herpes virus infection in cheetahs (Acinonyx jubatus)",
abstract = "A chronic ulcerative and eosinophilic dermatitis occurred in 20 captive cheetahs (Acinonyx jubatus) with persistent feline herpes virus 1 (FHV1) infection. Affected animals had erythematous, ulcerated plaques primarily on the face and forelegs in sites of contact with lachrymal and salivary secretions. The dermatitis was characterized by dense infiltrates of eosinophils and plasma cells and pseudoepitheliomatous hyperplasia. Rare keratinocytes within the lesions had nuclei with marginated chromatin and small eosinophilic inclusions composed of herpes virus nucleocapsids. Virus isolated from lesions was confirmed to be FHV1. Lesions persisted and progressed unless removed by cryoexcision. The occurrence of this unusual reaction to FHV1 in approximately 5{\%} of captive North American cheetahs suggests a species propensity for a Th2-dominant response to herpes virus infection. This atypical immune reaction may indicate a heritable trait or modulation of the immune response by other factors such as chronic stress.",
keywords = "Acinonyx jubatus, Cheetahs, Dermatitis, Eosinophils, Feline herpes virus 1, Pseudoepitheliomatous hyperplasia",
author = "L. Munson and R. Wack and M. Duncan and Montali, {R. J.} and D. Boon and I. Stalis and Crawshaw, {G. J.} and Cameron, {K. N.} and J. Mortenson and S. Citino and J. Zuba and Junge, {R. E.}",
year = "2004",
month = "3",
doi = "10.1354/vp.41-2-170",
language = "English (US)",
volume = "41",
pages = "170--176",
journal = "Veterinary Pathology",
issn = "0300-9858",
publisher = "SAGE Publications Ltd",
number = "2",

}

TY - JOUR

T1 - Chronic eosinophilic dermatitis associated with persistent feline herpes virus infection in cheetahs (Acinonyx jubatus)

AU - Munson, L.

AU - Wack, R.

AU - Duncan, M.

AU - Montali, R. J.

AU - Boon, D.

AU - Stalis, I.

AU - Crawshaw, G. J.

AU - Cameron, K. N.

AU - Mortenson, J.

AU - Citino, S.

AU - Zuba, J.

AU - Junge, R. E.

PY - 2004/3

Y1 - 2004/3

N2 - A chronic ulcerative and eosinophilic dermatitis occurred in 20 captive cheetahs (Acinonyx jubatus) with persistent feline herpes virus 1 (FHV1) infection. Affected animals had erythematous, ulcerated plaques primarily on the face and forelegs in sites of contact with lachrymal and salivary secretions. The dermatitis was characterized by dense infiltrates of eosinophils and plasma cells and pseudoepitheliomatous hyperplasia. Rare keratinocytes within the lesions had nuclei with marginated chromatin and small eosinophilic inclusions composed of herpes virus nucleocapsids. Virus isolated from lesions was confirmed to be FHV1. Lesions persisted and progressed unless removed by cryoexcision. The occurrence of this unusual reaction to FHV1 in approximately 5% of captive North American cheetahs suggests a species propensity for a Th2-dominant response to herpes virus infection. This atypical immune reaction may indicate a heritable trait or modulation of the immune response by other factors such as chronic stress.

AB - A chronic ulcerative and eosinophilic dermatitis occurred in 20 captive cheetahs (Acinonyx jubatus) with persistent feline herpes virus 1 (FHV1) infection. Affected animals had erythematous, ulcerated plaques primarily on the face and forelegs in sites of contact with lachrymal and salivary secretions. The dermatitis was characterized by dense infiltrates of eosinophils and plasma cells and pseudoepitheliomatous hyperplasia. Rare keratinocytes within the lesions had nuclei with marginated chromatin and small eosinophilic inclusions composed of herpes virus nucleocapsids. Virus isolated from lesions was confirmed to be FHV1. Lesions persisted and progressed unless removed by cryoexcision. The occurrence of this unusual reaction to FHV1 in approximately 5% of captive North American cheetahs suggests a species propensity for a Th2-dominant response to herpes virus infection. This atypical immune reaction may indicate a heritable trait or modulation of the immune response by other factors such as chronic stress.

KW - Acinonyx jubatus

KW - Cheetahs

KW - Dermatitis

KW - Eosinophils

KW - Feline herpes virus 1

KW - Pseudoepitheliomatous hyperplasia

UR - http://www.scopus.com/inward/record.url?scp=11144357853&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11144357853&partnerID=8YFLogxK

U2 - 10.1354/vp.41-2-170

DO - 10.1354/vp.41-2-170

M3 - Article

C2 - 15017031

AN - SCOPUS:11144357853

VL - 41

SP - 170

EP - 176

JO - Veterinary Pathology

JF - Veterinary Pathology

SN - 0300-9858

IS - 2

ER -