Abstract
Chronic corticosteroid treatment in humans is frequently complicated by behavioral changes. The present study suggests that chronic steroid administration in rats has distinct neurochemical consequences which are behaviorally relevant. Ten male Sprague-Dawley rats received 7 daily injections of corticosterone, following which they exhibited increased caudate homovanillic acid as well as an attenuated decline in vertical and ambulatory movement (functional measures of dopamine activity) compared to placebo-treated rats. A subgroup of steroid-treated rats which was more behaviorally responsive to ccrticosterone also showed increased caudate 5-hdroxyindole acetic and decread prefrontal cortex dopamine and serotonin. These results are discussed in relation to the known behavioral side effects of chronic corticosteroid administration in man and the psychiatric manifestations of naturally occuring states of hypercortisolemia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 329-338 |
| Number of pages | 10 |
| Journal | European Journal of Pharmacology |
| Volume | 122 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 2 1986 |
| Externally published | Yes |
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Keywords
- Corticosterone
- Dopamine
- Habituation
- Locomotion
- Serotonin
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Chronic corticosterone administration in rats : Behavioral and biochemical evidence of increased central dopaminergic activity. / Wolkowitz, Owen; Sutton, Mary; Koulo, Markku; Labarca, Rodrigo; Wilkinson, Lynn; Doran, Allen; Hauger, Richard; Pickar, David; Crawley, Jacqueline.
In: European Journal of Pharmacology, Vol. 122, No. 3, 02.04.1986, p. 329-338.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic corticosterone administration in rats
T2 - Behavioral and biochemical evidence of increased central dopaminergic activity
AU - Wolkowitz, Owen
AU - Sutton, Mary
AU - Koulo, Markku
AU - Labarca, Rodrigo
AU - Wilkinson, Lynn
AU - Doran, Allen
AU - Hauger, Richard
AU - Pickar, David
AU - Crawley, Jacqueline
PY - 1986/4/2
Y1 - 1986/4/2
N2 - Chronic corticosteroid treatment in humans is frequently complicated by behavioral changes. The present study suggests that chronic steroid administration in rats has distinct neurochemical consequences which are behaviorally relevant. Ten male Sprague-Dawley rats received 7 daily injections of corticosterone, following which they exhibited increased caudate homovanillic acid as well as an attenuated decline in vertical and ambulatory movement (functional measures of dopamine activity) compared to placebo-treated rats. A subgroup of steroid-treated rats which was more behaviorally responsive to ccrticosterone also showed increased caudate 5-hdroxyindole acetic and decread prefrontal cortex dopamine and serotonin. These results are discussed in relation to the known behavioral side effects of chronic corticosteroid administration in man and the psychiatric manifestations of naturally occuring states of hypercortisolemia.
AB - Chronic corticosteroid treatment in humans is frequently complicated by behavioral changes. The present study suggests that chronic steroid administration in rats has distinct neurochemical consequences which are behaviorally relevant. Ten male Sprague-Dawley rats received 7 daily injections of corticosterone, following which they exhibited increased caudate homovanillic acid as well as an attenuated decline in vertical and ambulatory movement (functional measures of dopamine activity) compared to placebo-treated rats. A subgroup of steroid-treated rats which was more behaviorally responsive to ccrticosterone also showed increased caudate 5-hdroxyindole acetic and decread prefrontal cortex dopamine and serotonin. These results are discussed in relation to the known behavioral side effects of chronic corticosteroid administration in man and the psychiatric manifestations of naturally occuring states of hypercortisolemia.
KW - Corticosterone
KW - Dopamine
KW - Habituation
KW - Locomotion
KW - Serotonin
UR - http://www.scopus.com/inward/record.url?scp=0022521340&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022521340&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(86)90413-9
DO - 10.1016/0014-2999(86)90413-9
M3 - Article
C2 - 3709658
AN - SCOPUS:0022521340
VL - 122
SP - 329
EP - 338
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3
ER -