Chronic corticosterone administration in rats: Behavioral and biochemical evidence of increased central dopaminergic activity

Owen Wolkowitz; Mary Sutton; Markku Koulo; Rodrigo Labarca; Lynn Wilkinson; Allen Doran; Richard Hauger; David Pickar; Jacqueline Crawley

doi:10.1016/0014-2999(86)90413-9

Chronic corticosterone administration in rats: Behavioral and biochemical evidence of increased central dopaminergic activity

Owen Wolkowitz, Mary Sutton, Markku Koulo, Rodrigo Labarca, Lynn Wilkinson, Allen Doran, Richard Hauger, David Pickar, Jacqueline Crawley

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Chronic corticosteroid treatment in humans is frequently complicated by behavioral changes. The present study suggests that chronic steroid administration in rats has distinct neurochemical consequences which are behaviorally relevant. Ten male Sprague-Dawley rats received 7 daily injections of corticosterone, following which they exhibited increased caudate homovanillic acid as well as an attenuated decline in vertical and ambulatory movement (functional measures of dopamine activity) compared to placebo-treated rats. A subgroup of steroid-treated rats which was more behaviorally responsive to ccrticosterone also showed increased caudate 5-hdroxyindole acetic and decread prefrontal cortex dopamine and serotonin. These results are discussed in relation to the known behavioral side effects of chronic corticosteroid administration in man and the psychiatric manifestations of naturally occuring states of hypercortisolemia.

Original language	English (US)
Pages (from-to)	329-338
Number of pages	10
Journal	European Journal of Pharmacology
Volume	122
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(86)90413-9
State	Published - Apr 2 1986
Externally published	Yes

Keywords

Corticosterone
Dopamine
Habituation
Locomotion
Serotonin

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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10.1016/0014-2999(86)90413-9

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Chronic corticosterone administration in rats : Behavioral and biochemical evidence of increased central dopaminergic activity. / Wolkowitz, Owen; Sutton, Mary; Koulo, Markku; Labarca, Rodrigo; Wilkinson, Lynn; Doran, Allen; Hauger, Richard; Pickar, David; Crawley, Jacqueline.

In: European Journal of Pharmacology, Vol. 122, No. 3, 02.04.1986, p. 329-338.

Research output: Contribution to journal › Article › peer-review

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abstract = "Chronic corticosteroid treatment in humans is frequently complicated by behavioral changes. The present study suggests that chronic steroid administration in rats has distinct neurochemical consequences which are behaviorally relevant. Ten male Sprague-Dawley rats received 7 daily injections of corticosterone, following which they exhibited increased caudate homovanillic acid as well as an attenuated decline in vertical and ambulatory movement (functional measures of dopamine activity) compared to placebo-treated rats. A subgroup of steroid-treated rats which was more behaviorally responsive to ccrticosterone also showed increased caudate 5-hdroxyindole acetic and decread prefrontal cortex dopamine and serotonin. These results are discussed in relation to the known behavioral side effects of chronic corticosteroid administration in man and the psychiatric manifestations of naturally occuring states of hypercortisolemia.",

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AU - Wilkinson, Lynn

AU - Doran, Allen

AU - Hauger, Richard

AU - Pickar, David

AU - Crawley, Jacqueline

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N2 - Chronic corticosteroid treatment in humans is frequently complicated by behavioral changes. The present study suggests that chronic steroid administration in rats has distinct neurochemical consequences which are behaviorally relevant. Ten male Sprague-Dawley rats received 7 daily injections of corticosterone, following which they exhibited increased caudate homovanillic acid as well as an attenuated decline in vertical and ambulatory movement (functional measures of dopamine activity) compared to placebo-treated rats. A subgroup of steroid-treated rats which was more behaviorally responsive to ccrticosterone also showed increased caudate 5-hdroxyindole acetic and decread prefrontal cortex dopamine and serotonin. These results are discussed in relation to the known behavioral side effects of chronic corticosteroid administration in man and the psychiatric manifestations of naturally occuring states of hypercortisolemia.

AB - Chronic corticosteroid treatment in humans is frequently complicated by behavioral changes. The present study suggests that chronic steroid administration in rats has distinct neurochemical consequences which are behaviorally relevant. Ten male Sprague-Dawley rats received 7 daily injections of corticosterone, following which they exhibited increased caudate homovanillic acid as well as an attenuated decline in vertical and ambulatory movement (functional measures of dopamine activity) compared to placebo-treated rats. A subgroup of steroid-treated rats which was more behaviorally responsive to ccrticosterone also showed increased caudate 5-hdroxyindole acetic and decread prefrontal cortex dopamine and serotonin. These results are discussed in relation to the known behavioral side effects of chronic corticosteroid administration in man and the psychiatric manifestations of naturally occuring states of hypercortisolemia.

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KW - Serotonin

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Chronic corticosterone administration in rats: Behavioral and biochemical evidence of increased central dopaminergic activity

Abstract

Keywords

ASJC Scopus subject areas

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