Chronic bacterial pathogens: Mechanisms of persistence

Mariana X. Byndloss, Renee M. Tsolis

Research output: Chapter in Book/Report/Conference proceedingChapter


Persistent bacterial infections such as brucellosis and typhoid fever are characterized by a long incubation period that leads to chronic, sometimes lifelong, debilitating disease with serious clinical manifestations (1). Therefore, chronic bacterial diseases have a significant impact on public health, due to the utilization of resources for long-term treatment of patients (2). Additionally, chronic infections affect the ability of the ill to provide for their families, resulting in a significant socioeconomic burden in affected countries (3). ©

Original languageEnglish (US)
Title of host publicationVirulence Mechanisms of Bacterial Pathogens
Number of pages16
ISBN (Electronic)9781683670711
ISBN (Print)9781555819279
StatePublished - Apr 9 2016


  • Anti-inflammatory cytokines
  • Brucella species
  • Chronic bacterial pathogens
  • Classically activated macrophage
  • Host cell metabolism
  • Host immune response
  • Innate immune system
  • Salmonella typhi

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)


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