Chromosome 19p in Alzheimer's disease: When genome meets transcriptome

Jiajia Wang, Xuemei Feng, Zhouxian Bai, Lee-Way Jin, Yong Duand, Hongxing Lei

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Genetic studies have identified several genomic loci including chr19p13.2 relevant to Alzheimer's disease (AD) susceptibility. However, the functional roles of these genomic loci in AD pathogenesis require further clarification. Transcriptome as an endophenotype is critical for the understanding of disease mechanism. Here we demonstrate that chr19p is the most significantly perturbed chromosome region in AD brain transcriptome. With dual evidence from genome and transcriptome, chr19p likely play a special role in AD pathogenesis.

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalJournal of Alzheimer's Disease
Volume38
Issue number2
DOIs
StatePublished - 2014

Keywords

  • Chromosome 19p
  • complement C3
  • gene expression
  • genetic association
  • KANK2

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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