Chromosomal Organization of Mammalian POU Domain Factors

Yu Rong Xia, Bogi Andersen, Margarete Mehrabian, Anh T. Diep, Craig H Warden, T. Mohandas, Robert J. McEvilly, Michael G. Rosenfeld, Aldons J. Lusis

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


We present the chromosomal locations in mouse of eight new members of the mammalian POU domain family of transcriptional regulators. Chromosomal assignments were made for Brn-1 (Chr 14), Brn-2 (Chr 4), Brn-4 (Chr X), Brn-3.0 (Chr 14), Brn-3.1 (Chr 18), Brn-5.0 (Chr 15), Skn-1a/i (Chr 9), and Sprm-1 (Chr 13) in addition to the previously reported Pit-1 (Chr 16), Tst-1 (Chr 4), Oct-3/4 (Chr 17), Oct-1 (Chr 1), and Oct-2 (Chr 7) genes. Several conclusions have emerged from this analysis. First, among the most highly related family members (Brn-1, Brn-2, Brn-4, and Tst-1; Brn-3.0 and Brn-3.1; Oct-1, Oct-2, and Skn-1a/i) no chromosomal linkage is noted. Second, no clusters of genes are observed, irrespective of homology. Finally, no obvious linkages to genes for known additional regulatory factors with a specific origin of cell type are apparent. Thus, members of this large gene family, presumably arising as duplication events from common ancestral genes, apparently function in distinct chromosomal milieu under independent regulation. Some of these newly localized genes map in close proximity to existing mouse mutations.

Original languageEnglish (US)
Pages (from-to)126-130
Number of pages5
Issue number1
StatePublished - Oct 1993

ASJC Scopus subject areas

  • Genetics


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