Chromosomal localization of the human and mouse hyaluronan synthase genes

Andrew P. Spicer, Michael F Seldin, Anne S. Olsen, Nicholas Brown, Dan E. Wells, Norman A. Doggett, Naoki Itano, Koji Kimata, Joji Inazawa, John A. McDonald

Research output: Contribution to journalArticle

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Abstract

We have recently identified a new vertebrate gene family encoding putative hyaluronan (HA) synthases. Three highly conserved related genes have been identified, designated HAS1, HAS2, and HAS3 in humans and Has1, Has2, and Has3 in the mouse. All three genes encode predicted plasma membrane proteins with multiple transmembrane domains and approximately 25% amine acid sequence identity to the Streptococcus pyogenes HA synthase, HasA. Furthermore, expression of any one HAS gene in transfected mammalian cells leads to high levels of HA biosynthesis. We now report the chromosomal localization of the three HAS genes in human and in mouse. The genes localized to three different positions within both the human and the mouse genomes. HAS1 was localized to the human chromosome 19q13.3-q13.4 boundary and Has1 to mouse Chr 17. HAS2 was localized to human chromosome 8q24.12 and Has2 to mouse Chr 15. HAS3 was localized to human chromosome 16q22.1 and Has3 to mouse Chr 8. The map position for HAS1 reinforces the recently reported relationship between a small region of human chromosome 19q and proximal mouse chromosome 17. HAS2 mapped outside the predicted critical region delineated for the Langer-Giedion syndrome and can thus be excluded as a candidate gene for this genetic syndrome.

Original languageEnglish (US)
Pages (from-to)493-497
Number of pages5
JournalGenomics
Volume41
Issue number3
DOIs
StatePublished - May 1 1997

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Human Chromosomes
Genes
Langer-Giedion Syndrome
Chromosomes, Human, Pair 17
Streptococcus pyogenes
Human Genome
Hyaluronic Acid
hyaluronan synthase
Amines
Vertebrates
Blood Proteins
Membrane Proteins
Cell Membrane
Acids

ASJC Scopus subject areas

  • Genetics

Cite this

Spicer, A. P., Seldin, M. F., Olsen, A. S., Brown, N., Wells, D. E., Doggett, N. A., ... McDonald, J. A. (1997). Chromosomal localization of the human and mouse hyaluronan synthase genes. Genomics, 41(3), 493-497. https://doi.org/10.1006/geno.1997.4696

Chromosomal localization of the human and mouse hyaluronan synthase genes. / Spicer, Andrew P.; Seldin, Michael F; Olsen, Anne S.; Brown, Nicholas; Wells, Dan E.; Doggett, Norman A.; Itano, Naoki; Kimata, Koji; Inazawa, Joji; McDonald, John A.

In: Genomics, Vol. 41, No. 3, 01.05.1997, p. 493-497.

Research output: Contribution to journalArticle

Spicer, AP, Seldin, MF, Olsen, AS, Brown, N, Wells, DE, Doggett, NA, Itano, N, Kimata, K, Inazawa, J & McDonald, JA 1997, 'Chromosomal localization of the human and mouse hyaluronan synthase genes', Genomics, vol. 41, no. 3, pp. 493-497. https://doi.org/10.1006/geno.1997.4696
Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA et al. Chromosomal localization of the human and mouse hyaluronan synthase genes. Genomics. 1997 May 1;41(3):493-497. https://doi.org/10.1006/geno.1997.4696
Spicer, Andrew P. ; Seldin, Michael F ; Olsen, Anne S. ; Brown, Nicholas ; Wells, Dan E. ; Doggett, Norman A. ; Itano, Naoki ; Kimata, Koji ; Inazawa, Joji ; McDonald, John A. / Chromosomal localization of the human and mouse hyaluronan synthase genes. In: Genomics. 1997 ; Vol. 41, No. 3. pp. 493-497.
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