Abstract
Opiate receptors are the primary targets for the drugs of abuse morphine and heroin. In this study, we completed the localization on mouse chromosomes of the genes encoding mu (Oprm) and kappa (Oprk) receptors, as well as the genes for the opioid propeptides proenkephalin (Penk) and prodynorphin (Pdyn). The genetic mapping was performed using a panel of DNA samples from an interspecific cross [C3H/HeJ-gld and (C3H/HeJ-gld x Mus spretus)Fi] that has been characterized for more than 800 markers throughout the genome. The genes are localized on mouse Chr 1 (Oprk, 10 cM from the centromere), Chr 2 (Pdyn, 75 cM from the centromere), Chr 4 (Penk, 1 cM from the centromere) and Chr 10 (Oprm, 10 cM from the centromere). Interestingly, the gene for the mu receptor is located in the same region as a Quantitative Trait Locus for high morphine consumption, thus raising the possibility of its direct role in drug abuse mechanisms.
| Original language | English (US) |
|---|---|
| Journal | Life Sciences |
| Volume | 56 |
| Issue number | 18 |
| DOIs | |
| State | Published - Mar 24 1995 |
| Externally published | Yes |
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Keywords
- chromosomal localization
- drug addiction
- genes
- opioid peptides
- opioid receptors
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology
Cite this
Chromosomal localization of opioid peptide and receptor genes in the mouse. / Giros, Bruno; Pohl, Michel; Rochelle, Julie M.; Seldin, Michael F.
In: Life Sciences, Vol. 56, No. 18, 24.03.1995.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chromosomal localization of opioid peptide and receptor genes in the mouse
AU - Giros, Bruno
AU - Pohl, Michel
AU - Rochelle, Julie M.
AU - Seldin, Michael F
PY - 1995/3/24
Y1 - 1995/3/24
N2 - Opiate receptors are the primary targets for the drugs of abuse morphine and heroin. In this study, we completed the localization on mouse chromosomes of the genes encoding mu (Oprm) and kappa (Oprk) receptors, as well as the genes for the opioid propeptides proenkephalin (Penk) and prodynorphin (Pdyn). The genetic mapping was performed using a panel of DNA samples from an interspecific cross [C3H/HeJ-gld and (C3H/HeJ-gld x Mus spretus)Fi] that has been characterized for more than 800 markers throughout the genome. The genes are localized on mouse Chr 1 (Oprk, 10 cM from the centromere), Chr 2 (Pdyn, 75 cM from the centromere), Chr 4 (Penk, 1 cM from the centromere) and Chr 10 (Oprm, 10 cM from the centromere). Interestingly, the gene for the mu receptor is located in the same region as a Quantitative Trait Locus for high morphine consumption, thus raising the possibility of its direct role in drug abuse mechanisms.
AB - Opiate receptors are the primary targets for the drugs of abuse morphine and heroin. In this study, we completed the localization on mouse chromosomes of the genes encoding mu (Oprm) and kappa (Oprk) receptors, as well as the genes for the opioid propeptides proenkephalin (Penk) and prodynorphin (Pdyn). The genetic mapping was performed using a panel of DNA samples from an interspecific cross [C3H/HeJ-gld and (C3H/HeJ-gld x Mus spretus)Fi] that has been characterized for more than 800 markers throughout the genome. The genes are localized on mouse Chr 1 (Oprk, 10 cM from the centromere), Chr 2 (Pdyn, 75 cM from the centromere), Chr 4 (Penk, 1 cM from the centromere) and Chr 10 (Oprm, 10 cM from the centromere). Interestingly, the gene for the mu receptor is located in the same region as a Quantitative Trait Locus for high morphine consumption, thus raising the possibility of its direct role in drug abuse mechanisms.
KW - chromosomal localization
KW - drug addiction
KW - genes
KW - opioid peptides
KW - opioid receptors
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U2 - 10.1016/0024-3205(95)00119-Q
DO - 10.1016/0024-3205(95)00119-Q
M3 - Article
C2 - 7752808
AN - SCOPUS:0028929251
VL - 56
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 18
ER -