Chromosomal localization of opioid peptide and receptor genes in the mouse

Bruno Giros; Michel Pohl; Julie M. Rochelle; Michael F Seldin

doi:10.1016/0024-3205(95)00119-Q

Chromosomal localization of opioid peptide and receptor genes in the mouse

Bruno Giros, Michel Pohl, Julie M. Rochelle, Michael F Seldin

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Opiate receptors are the primary targets for the drugs of abuse morphine and heroin. In this study, we completed the localization on mouse chromosomes of the genes encoding mu (Oprm) and kappa (Oprk) receptors, as well as the genes for the opioid propeptides proenkephalin (Penk) and prodynorphin (Pdyn). The genetic mapping was performed using a panel of DNA samples from an interspecific cross [C3H/HeJ-gld and (C3H/HeJ-gld x Mus spretus)Fi] that has been characterized for more than 800 markers throughout the genome. The genes are localized on mouse Chr 1 (Oprk, 10 cM from the centromere), Chr 2 (Pdyn, 75 cM from the centromere), Chr 4 (Penk, 1 cM from the centromere) and Chr 10 (Oprm, 10 cM from the centromere). Interestingly, the gene for the mu receptor is located in the same region as a Quantitative Trait Locus for high morphine consumption, thus raising the possibility of its direct role in drug abuse mechanisms.

Original language	English (US)
Journal	Life Sciences
Volume	56
Issue number	18
DOIs	https://doi.org/10.1016/0024-3205(95)00119-Q
State	Published - Mar 24 1995
Externally published	Yes

Keywords

chromosomal localization
drug addiction
genes
opioid peptides
opioid receptors

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology

Access to Document

10.1016/0024-3205(95)00119-Q

Cite this

@article{85d66f1e4b404f0b8b732ba27b8d7384,

title = "Chromosomal localization of opioid peptide and receptor genes in the mouse",

abstract = "Opiate receptors are the primary targets for the drugs of abuse morphine and heroin. In this study, we completed the localization on mouse chromosomes of the genes encoding mu (Oprm) and kappa (Oprk) receptors, as well as the genes for the opioid propeptides proenkephalin (Penk) and prodynorphin (Pdyn). The genetic mapping was performed using a panel of DNA samples from an interspecific cross [C3H/HeJ-gld and (C3H/HeJ-gld x Mus spretus)Fi] that has been characterized for more than 800 markers throughout the genome. The genes are localized on mouse Chr 1 (Oprk, 10 cM from the centromere), Chr 2 (Pdyn, 75 cM from the centromere), Chr 4 (Penk, 1 cM from the centromere) and Chr 10 (Oprm, 10 cM from the centromere). Interestingly, the gene for the mu receptor is located in the same region as a Quantitative Trait Locus for high morphine consumption, thus raising the possibility of its direct role in drug abuse mechanisms.",

keywords = "chromosomal localization, drug addiction, genes, opioid peptides, opioid receptors",

author = "Bruno Giros and Michel Pohl and Rochelle, {Julie M.} and Seldin, {Michael F}",

year = "1995",

month = mar,

day = "24",

doi = "10.1016/0024-3205(95)00119-Q",

language = "English (US)",

volume = "56",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "18",

}

TY - JOUR

T1 - Chromosomal localization of opioid peptide and receptor genes in the mouse

AU - Giros, Bruno

AU - Pohl, Michel

AU - Rochelle, Julie M.

AU - Seldin, Michael F

PY - 1995/3/24

Y1 - 1995/3/24

N2 - Opiate receptors are the primary targets for the drugs of abuse morphine and heroin. In this study, we completed the localization on mouse chromosomes of the genes encoding mu (Oprm) and kappa (Oprk) receptors, as well as the genes for the opioid propeptides proenkephalin (Penk) and prodynorphin (Pdyn). The genetic mapping was performed using a panel of DNA samples from an interspecific cross [C3H/HeJ-gld and (C3H/HeJ-gld x Mus spretus)Fi] that has been characterized for more than 800 markers throughout the genome. The genes are localized on mouse Chr 1 (Oprk, 10 cM from the centromere), Chr 2 (Pdyn, 75 cM from the centromere), Chr 4 (Penk, 1 cM from the centromere) and Chr 10 (Oprm, 10 cM from the centromere). Interestingly, the gene for the mu receptor is located in the same region as a Quantitative Trait Locus for high morphine consumption, thus raising the possibility of its direct role in drug abuse mechanisms.

AB - Opiate receptors are the primary targets for the drugs of abuse morphine and heroin. In this study, we completed the localization on mouse chromosomes of the genes encoding mu (Oprm) and kappa (Oprk) receptors, as well as the genes for the opioid propeptides proenkephalin (Penk) and prodynorphin (Pdyn). The genetic mapping was performed using a panel of DNA samples from an interspecific cross [C3H/HeJ-gld and (C3H/HeJ-gld x Mus spretus)Fi] that has been characterized for more than 800 markers throughout the genome. The genes are localized on mouse Chr 1 (Oprk, 10 cM from the centromere), Chr 2 (Pdyn, 75 cM from the centromere), Chr 4 (Penk, 1 cM from the centromere) and Chr 10 (Oprm, 10 cM from the centromere). Interestingly, the gene for the mu receptor is located in the same region as a Quantitative Trait Locus for high morphine consumption, thus raising the possibility of its direct role in drug abuse mechanisms.

KW - chromosomal localization

KW - drug addiction

KW - genes

KW - opioid peptides

KW - opioid receptors

UR - http://www.scopus.com/inward/record.url?scp=0028929251&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028929251&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(95)00119-Q

DO - 10.1016/0024-3205(95)00119-Q

M3 - Article

C2 - 7752808

AN - SCOPUS:0028929251

VL - 56

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 18

ER -

Chromosomal localization of opioid peptide and receptor genes in the mouse

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this