Chromosomal localization of opioid peptide and receptor genes in the mouse

Bruno Giros, Michel Pohl, Julie M. Rochelle, Michael F Seldin

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Opiate receptors are the primary targets for the drugs of abuse morphine and heroin. In this study, we completed the localization on mouse chromosomes of the genes encoding mu (Oprm) and kappa (Oprk) receptors, as well as the genes for the opioid propeptides proenkephalin (Penk) and prodynorphin (Pdyn). The genetic mapping was performed using a panel of DNA samples from an interspecific cross [C3H/HeJ-gld and (C3H/HeJ-gld x Mus spretus)Fi] that has been characterized for more than 800 markers throughout the genome. The genes are localized on mouse Chr 1 (Oprk, 10 cM from the centromere), Chr 2 (Pdyn, 75 cM from the centromere), Chr 4 (Penk, 1 cM from the centromere) and Chr 10 (Oprm, 10 cM from the centromere). Interestingly, the gene for the mu receptor is located in the same region as a Quantitative Trait Locus for high morphine consumption, thus raising the possibility of its direct role in drug abuse mechanisms.

Original languageEnglish (US)
JournalLife Sciences
Volume56
Issue number18
DOIs
StatePublished - Mar 24 1995
Externally publishedYes

Keywords

  • chromosomal localization
  • drug addiction
  • genes
  • opioid peptides
  • opioid receptors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology

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